NS-2359
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| Systematic (IUPAC) name | |
|---|---|
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(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-azabicyclo[3.2.1]octane
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| Identifiers | |
| ATC code | none |
| PubChem | CID: 11408320 |
| Chemical data | |
| Formula | C15H19Cl2NO |
| Molecular mass | 300.223 g/mol |
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| (verify) | |
NS-2359 (GSK-372,475) is a serotonin-norepinephrine-dopamine reuptake inhibitor. It was under development by GlaxoSmithKline (GSK) as an antidepressant,[1] but was discontinued in 2009 when phase II clinical trials turned up disappointing results and did not support further effort by the company.[1] NS-2359 was also in clinical trials for the treatment of ADHD,[2] phase II having been completed in 2007.[3] A trial exploring the effect of NS-2359 on cocaine-experienced individuals is currently ongoing.[4]
Another scientific article on NS-2359 was recently (2011) published.[5] As can be seen from reading the abstract to the citation, the compound failed to perform in clinical trials for the treatment of depression.
See also
References
- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://clinicaltrials.gov/ct2/show/NCT00467428
- ↑ http://clinicaltrials.gov/ct2/show/NCT00032916
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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