Naptumomab estafenatox
| Monoclonal antibody | |
|---|---|
| Type | Fab fragment |
| Source | Mouse |
| Target | 5T4 |
| Identifiers | |
| CAS Number | 676258-98-3  |
| ATC code | none |
| UNII | 93T929W6LC |
| Chemical data | |
| Formula | C3255H5025N855O1050S18 |
| Molecular mass | 73.5 kg/mol |
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Naptumomab estafenatox (ABR-217620) is a drug being developed for the treatment of various types of cancer like non-small cell lung carcinoma[1] and renal cell carcinoma.[2]
Mechanism of action
Chemically, it is a fusion protein consisting of the antigen-binding fragment (Fab) of a monoclonal antibody with the superantigen staphylococcal enterotoxin A (SEA/E-120, "estafenatox").[3] The Fab binds to 5T4, an antigen expressed by various tumor cells, and the superantigen induces an immune response by activating T lymphocytes.
See also
- Nacolomab tafenatox, a drug with a similar chemical structure and mechanism
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ ClinicalTrials.gov
- ↑ WHO Drug Information
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