Nuclear receptor co-repressor 1

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.[1][2]

NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of gene expression.[1][3]

Loss of function of this protein significantly increases the strength and power of mouse muscles.[4]

Interactions

Nuclear receptor co-repressor 1 has been shown to interact with:

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References

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Further reading

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External links

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