Oxicam
Oxicam is a class of non-steroidal anti-inflammatory drugs (NSAIDs) that bind closely to plasma proteins.[1] Most oxicams are unselective inhibitors of the cyclooxygenase (COX) enzymes. The exception is meloxicam with a slight (10:1) preference for COX-2, which, however, is only clinically relevant at low doses.[2]
Examples include:
Chemistry
The physico-chemical characteristics of these molecules vary greatly depending upon the environment.[3]
In contrast to most other NSAIDs, oxicams are not carboxylic acids. They are tautomeric and can exist as number of tautomers (keto-enol tautomerism), here exemplified by piroxicam:[4]
References
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