PTGES

Prostaglandin E synthase
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3DWW, 4AL0, 4AL1, 4BPM, 4WAB
Identifiers
Symbols	PTGES ; MGST-IV; MGST1-L1; MGST1L1; MPGES; PGES; PIG12; PP102; PP1294; TP53I12; mPGES-1
External IDs	OMIM: 605172 MGI: 1927593 HomoloGene: 3587 ChEMBL: 5658 GeneCards: PTGES Gene
EC number	5.3.99.3
Gene ontology Molecular function • glutathione binding • prostaglandin-E synthase activity Cellular component • nuclear envelope lumen • endoplasmic reticulum membrane • membrane • integral component of membrane • perinuclear region of cytoplasm Biological process • prostaglandin biosynthetic process • acute inflammatory response • chronic inflammatory response • prostaglandin metabolic process • signal transduction • negative regulation of cell proliferation • response to organic cyclic compound • arachidonic acid metabolic process • cyclooxygenase pathway • response to lipopolysaccharide • response to retinoic acid • response to cytokine • small molecule metabolic process • response to calcium ion Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PTGES 210367 s at tn.png
File:PBB GE PTGES 207388 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9536	64292
Ensembl	ENSG00000148344	ENSMUSG00000050737
UniProt	O14684	Q9JM51
RefSeq (mRNA)	NM_004878	NM_022415
RefSeq (protein)	NP_004869	NP_071860
Location (UCSC)	Chr 9: 129.74 – 129.75 Mb	Chr 2: 30.89 – 30.93 Mb
PubMed search	[1]	[2]

Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.

Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

See also

• Prostaglandin E synthase