SLA2

Src-like-adaptor 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4M4Z
Identifiers
Symbols	SLA2 ; C20orf156; MARS; SLAP-2; SLAP2
External IDs	OMIM: 606577 HomoloGene: 49989 GeneCards: SLA2 Gene
Gene ontology Molecular function • SH3/SH2 adaptor activity • protein binding • protein N-terminus binding Cellular component • cytoplasm • late endosome • plasma membrane • endosome membrane • cytoplasmic membrane-bounded vesicle Biological process • negative regulation of transcription from RNA polymerase II promoter • positive regulation of signal transduction • B cell mediated immunity • intracellular receptor signaling pathway • T cell activation • regulation of immune response • negative regulation of calcium-mediated signaling • antigen receptor-mediated signaling pathway • negative regulation of B cell activation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84174	77799
Ensembl	ENSG00000101082	ENSMUSG00000027636
UniProt	Q9H6Q3	Q8R4L0
RefSeq (mRNA)	NM_032214	NM_029983
RefSeq (protein)	NP_115590	NP_084259
Location (UCSC)	Chr 20: 36.61 – 36.65 Mb	Chr 2: 156.87 – 156.89 Mb
PubMed search	[1]	[2]

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.

Function

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.

Interactions

SLA2 has been shown to interact with Cbl gene.