SYT6

Synaptotagmin VI
Identifiers
Symbols	SYT6 ; sytVI
External IDs	OMIM: 607718 MGI: 1859544 HomoloGene: 10301 GeneCards: SYT6 Gene
Gene ontology Molecular function • calcium ion binding • protein binding • calcium-dependent phospholipid binding • syntaxin binding • clathrin binding • protein homodimerization activity • protein heterodimerization activity • calcium-dependent protein binding Cellular component • cytosol • plasma membrane • integral component of membrane • extrinsic component of membrane • cell junction • synaptic vesicle membrane • perinuclear endoplasmic reticulum Biological process • synaptic vesicle exocytosis • regulation of calcium ion-dependent exocytosis • calcium ion-dependent exocytosis of neurotransmitter • acrosomal vesicle exocytosis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	148281	54524
Ensembl	ENSG00000134207	ENSMUSG00000027849
UniProt	Q5T7P8	Q9R0N8
RefSeq (mRNA)	NM_001253772	NM_001276676
RefSeq (protein)	NP_001257734	NP_001263605
Location (UCSC)	Chr 1: 114.09 – 114.15 Mb	Chr 3: 103.58 – 103.65 Mb
PubMed search	[1]	[2]

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM]