TGF beta receptor 2

Transforming growth factor, beta receptor II (70/80kDa)
PDB rendering based on 1ktz.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1KTZ, 1M9Z, 1PLO, 2PJY, 3KFD
Identifiers
Symbols	TGFBR2 ; AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII
External IDs	OMIM: 190182 MGI: 98729 HomoloGene: 2435 ChEMBL: 4267 GeneCards: TGFBR2 Gene
EC number	2.7.11.30
Gene ontology Molecular function • transmembrane receptor protein serine/threonine kinase activity • receptor signaling protein serine/threonine kinase activity • transforming growth factor beta-activated receptor activity • transforming growth factor beta receptor activity, type II • protein binding • ATP binding • glycosaminoglycan binding • mitogen-activated protein kinase kinase kinase binding • type I transforming growth factor beta receptor binding • type III transforming growth factor beta receptor binding • SMAD binding • metal ion binding • transforming growth factor beta binding Cellular component • cytosol • plasma membrane • caveola • external side of plasma membrane • integral component of membrane • receptor complex • transforming growth factor beta receptor homodimeric complex Biological process • blood vessel development • patterning of blood vessels • vasculogenesis • in utero embryonic development • positive regulation of mesenchymal cell proliferation • lens development in camera-type eye • positive regulation of tolerance induction to self antigen • positive regulation of B cell tolerance induction • positive regulation of T cell tolerance induction • growth plate cartilage chondrocyte growth • protein phosphorylation • receptor-mediated endocytosis • apoptotic process • transforming growth factor beta receptor signaling pathway • common-partner SMAD protein phosphorylation • smoothened signaling pathway • gastrulation • brain development • heart development • embryo implantation • aging • response to nutrient • positive regulation of cell proliferation • response to mechanical stimulus • response to glucose • regulation of gene expression • positive regulation of epithelial cell migration • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • signal transduction by protein phosphorylation • negative regulation of transforming growth factor beta receptor signaling pathway • organ regeneration • activation of protein kinase activity • embryonic hemopoiesis • wound healing • regulation of cell proliferation • response to drug • myeloid dendritic cell differentiation • positive regulation of skeletal muscle tissue regeneration • response to estrogen • positive regulation of angiogenesis • digestive tract development • positive regulation of smooth muscle cell proliferation • embryonic cranial skeleton morphogenesis • positive regulation of NK T cell differentiation • palate development • negative regulation of cardiac muscle cell proliferation • pathway-restricted SMAD protein phosphorylation • bronchus morphogenesis • trachea formation • mammary gland morphogenesis • lung lobe morphogenesis • response to cholesterol • lens fiber cell apoptotic process • positive regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7048	21813
Ensembl	ENSG00000163513	ENSMUSG00000032440
UniProt	P37173	Q62312
RefSeq (mRNA)	NM_001024847	NM_009371
RefSeq (protein)	NP_001020018	NP_033397
Location (UCSC)	Chr 3: 30.61 – 30.69 Mb	Chr 9: 116.09 – 116.18 Mb
PubMed search	[1]	[2]

Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene.

It is a tumor suppressor gene.

Function

This gene encodes a member of the serine/threonine protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Interactions

TGF beta receptor 2 has been shown to interact with:

• AP2B1,
• Cyclin B2,
• Endoglin,
• Heat shock protein 90kDa alpha (cytosolic), member A1
• STRAP,
• TGF beta receptor 1, and
• Transforming growth factor, beta 3.

Domain architecture

Transforming growth factor beta receptor 2 ectodomain
crystal structure of human tgf-beta type ii receptor ligand binding domain
Identifiers
Symbol	ecTbetaR2
Pfam	PF08917
InterPro	IPR015013
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

TGF beta receptor 2 consists of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).

See also

• TGF beta receptors

External links

• GeneReviews/NIH/NCBI/UW entry on Thoracic Aortic Aneurysms and Aortic Dissections

This article incorporates text from the public domain Pfam and InterPro IPR015013