Trans-activation response element (TAR)
| Trans-activation response element (TAR) | |
|---|---|
 |
|
| Predicted secondary structure and sequence conservation of mir-TAR | |
| Identifiers | |
| Symbol | mir-TAR |
| Alt. Symbols | TAR |
| Rfam | RF00250 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Viruses |
| GO | 0035068 0035195 |
| SO | 0000233 0001244 |
The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure[1] that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter.[2]
Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.[3] These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3,[4] CDK9 and Bim.[5]
References
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