Vesiculobullous disease

Vesiculobullous disease
Diagram showing cross section of vesicles (left) and bullae (right) on skin.
Classification and external resources
Specialty
ICD-10	L10-L14
ICD-9-CM	694
Patient UK	Vesiculobullous disease
MeSH	D012872

A vesiculobullous disease is a type of mucocutaneous disease that is characterized by vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon what definition is used). In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous, is sometimes used. Example vesiculobullous diseases include:

• Infectious: (viral)
  • Herpes simplex
  • Varicella-Zoster infection
  • Hand, foot and mouth disease
  • Herpangina
  • Measles (Rubeola)
• Immunobullous:
  • Pemphigus vulgaris
  • Pemphigoid
  • Dermatitis herpetiformis[1]
  • Linear immunoglobulin-A disease (linear IgA disease)
• Genetic:
  • Epidermolysis bullosa

Some features are as follows:

Name	Acantholysis?	Ig
epidermolysis bullosa	yes	mostly IgG
bullous pemphigoid	no	mostly IgG
dermatitis herpetiformis	no	IgA