Many states and hundreds of local municipalities have passed zoning laws prohibiting sex offender... more Many states and hundreds of local municipalities have passed zoning laws prohibiting sex offenders from living within close proximity to schools, parks, playgrounds, day care centers, and other places where children congregate. The purpose of this study was to investigate the positive and negative, intended and unintended consequences of residence restrictions on sex offenders. Results indicate that residence restrictions create housing instability for many offenders and limited accessibility to employment opportunities, social services, and social support. Young adult offenders were especially impacted because residence restrictions limited affordable housing options and often prevented them from living with family members. Implications for policy development and implementation are discussed.
Cochlear root neurons (CRNs) provide short-latency acoustic inputs to the caudal pontine reticula... more Cochlear root neurons (CRNs) provide short-latency acoustic inputs to the caudal pontine reticular nucleus that elicit an acoustic startle reflex (ASR). Auditory prepulse inhibition (PPI) of the acoustic startle response is the reduction in ASR magnitude that is observed when a strong acoustic startling stimulus (pulse) is shortly preceded by a weak sound (prepulse). It has been suggested that a short descending auditory pathway conveys auditory prepulses to the level of the CRNs to mediate the inhibition of ASR. However, no electrophysiological data is available to confirm such inhibition. We here investigated the effects of auditory prepulses on the neuronal activity of CRNs using extracellular recordings in vivo from single CRNs. Our results show that CRN responses are strongly inhibited by auditory prepulses. As occurs in the behavioral paradigm, the inhibition of the CRN responses depended on parameters of the auditory prepulse, such as intensity and interstimulus interval, showing their strongest inhibition at high intensity level and short interstimulus intervals. Furthermore, we tested the auditory PPI on the activity of different neuron types in the ventral cochlear nucleus. Of all neuron types tested, only CRNs exhibited a strong attenuation of activity. Our results corroborate our previous hypothesis that CRNs might be involved in the neural circuit of the inhibition of the ASR and suggest that several neuronal pathways participate in that circuit.
... Page 4. 148 María del Carmen Vergara Quintero, Consuelo Vélez Álvarez, José Armando Vidarte C... more ... Page 4. 148 María del Carmen Vergara Quintero, Consuelo Vélez Álvarez, José Armando Vidarte Claros, José Orlando Nieto Ramírez ... o Comprender lo que dicen los jóvenes acerca del riesgo, las prácticas relacionadas y el sentido que le dan a esas prácticas. ...
There are the theories for exploring Solar system formation in accord Titius-Bode's low: electrom... more There are the theories for exploring Solar system formation in accord Titius-Bode's low: electromagnetic theories (Birkeland (1912), Alfven (1942)), gravitational theories (Schmidt (1944), Woolfson (1964), Safronov (1969), Dole (1970)), nebular theories (Weizsaecker (1943), Kuiper (1949), Nakano (1970)) [1]-[3]. In spite of great number of work aimed to exploring formation of the Solar system, however, the mentioned theories were not able to explain all phenomena. In this connection the statistical theory for a cosmological body forming (so-called the spheroidal body model) has been proposed in [4]-[11]. Within the framework of this theory, bodies have fuzzy outlines and are represented by means of spheroidal forms. In the work [6], which is a continuation of the papers [4], [5], it has been investigated a slowly evolving in time process of a gravitational compression of a spheroidal body close to an unstable equilibrium state. In the papers [7],[8]the equation of motion of particles inside the weakly gravitating spheroidal body modeled by means of an ideal liquid has been obtained. Using Schwarzschild's and Kerr's metrics a consistency of the proposed statistical model with the general relativity has been shown in [12]. The proposed theory proceeds from the conception for forming a spheroidal body as a protoplanet from planetary nebula; it permits to derive the form of distribution functions for an immovable and rotating spheroidal body [4]-[6],[10]-[13] as well as their density masses (gravitational potentials and strengths) and also to find the distribution function of specific angular momentum of the rotating uniformly spheroidal body [13],[14]. Using the specific angular momentum distribution function this work considers a gas- dust protoplanetary cloud as a rotating and gravitating spheroidal body. Because the specific angular momenta are averaged during conglomeration process the specific angular momenta for a planets of Solar system is found. As a result a new low for Solar system planetary distances is derived (it generalizes the well-known Schmidt low). The new low gives a very good estimation of real planetary distances in Solar system (the relative error of estimation is 0%; absolute error of estimation is 0,5% besides its maximal value is equal to 5% for Earth and Pluto). This low has been applied also to estimation of Jupiter's satellities distances in this work. References: [1] M.M.Nieto, The Tutius-Bode low of planetary distances: its his-tory and theory. Pergamon: Oxford, New York et., 1972. [2] V.S. Safronov, Evolution of Protoplanetary cloud and the formation of the Earth and planets. 1969, Moscow, Nauka, (in Russian); NASA Tech. Transl. F-677, Washington, D.C. 1972. [3] A.V. Vityazev, G.V. Pechrnikova and V.S.Safronov, The Terrestrial planets: origin and early evolution. 1990. Moscow, Nauka (in Russian) [4] A.M.Krot, Achievement in Modern Radioelectronics (Special issue "Cosmic Radiophysics", Moscow), no.8, pp.66-81, 1996 (in Russian). [5] A.M.Krot, Proc. SPIE's 13th Annual Intern.Symp. "AeroSense", vol.3710, pp.1248-1259, Orlando, Florida, USA, April 5-9, 1999. [6] A.M.Krot, Proc. SPIE's 14th Annual Intern.Symp. "AeroSense", vol.4038, pp.1318-1329, Orlando, Florida, USA, April 24-28, 2000. [7] A.M.Krot, Proc. SPIE's 15th Annual Intern. Symposium "AeroSense", vol.4394, pp.1271-1282, Orlando, Florida, USA, April 16-20, 2001. [8] A.M.Krot, Proc. 53rd Intern. Astronautical Congress: The World Space Congress-2002, Houston, Texas, USA, October 10-19, 2002, Preprint IAC-02-J.P.01. - 11 p. [9] A.M.Krot, Proc. 34th Scientific Assembly of the Committee on Space Research (COSPAR)- The 2nd World Space Congress (WSC- 2002), October 10-19, 2002,Houston, Texas, USA. [10] A.M.Krot, Proc. of EGS- AGU-EUG Joint Assembly, Nice, France, April 6-11, 2003, Geophysical Research Abstracts, vol.5, EAE03-À-05568, 2003. [11] A.M. Krot, Proc. of 54 Intern. Astronautical Congress (IAC), September 29-October 3, 2003, Bremen, Germany, Preprint IAC-03-J.1.08. -11p. [12] A.M.Krot , Proc. of 35th COSPAR Scientific Assembly, Paris, France, July 18-25, 2004, Abstract-Nr. COSPAR 04-A-00162. [13] A.Krot, Proc. EGU- 2nd General Assembly, Vienna, Austria, April 24-29, 2005, Geophysical Research Abstracts, vol.7, EGU05-A-04550, 2005; SRef-ID: 1607-7962/gra/. [14] A.Krot Proc. EGU- General Assembly, Vienna, Austria, April 02- 07, 2006, Geophysical Research Abstracts, vol.8, EGU06-A-00216, 2006; SRef-ID: 1607-7962/gra/. 2
The presence of proto-oncogene mutations at codons 12, 13 and 61 of the Ha-, Ki-, and N-ras in pr... more The presence of proto-oncogene mutations at codons 12, 13 and 61 of the Ha-, Ki-, and N-ras in primary head and neck squamous cell carcinoma are analysed in this study.
En este documento se evalúa y analiza la relación entre las regalías directas y las coberturas mí... more En este documento se evalúa y analiza la relación entre las regalías directas y las coberturas mínimas alcanzadas por los municipios productores de petróleo para el periodo 2007-2008; mediante la metodología del análisis envolvente de datos. Esta metodología ha sido implementada en diferentes estudios que evalúan la eficiencia en la gestión gubernamental, sin embargo en Colombia no existe evidencia de su utilización en la gestión de las transferencias por explotación de petróleo. Los resultados obtenidos evidencian una eficiencia técnica pura promedio del 24% para el 2007 y 19.6% para el 2008, en los cuatro modelos analizados, de los que se concluye que son pocos los municipios que presentan un desempeño eficiente en cuanto a la gestión de las regalías.
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi oper... more We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average LAT gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of 2), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3GeV. In this paper, we also present the first results from the 4.5-month-long multifrequency campaign (2009 March 15 - August 1) on Mrk 501, which included the VLBA, Swift, RXTE, MAGIC and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton model. In the framework of this model, we find that the dominant emission region is characterized by a size <~ 0.1 pc (comparable within a factor of few to the size of the partially-resolved VLBA core at 15-43 GHz), and that the total jet power (~10^{44} erg s^{-1}) constitutes only a small fraction (~10^{-3}) of the Eddington luminosity. The energy distribution of the freshly-accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3GeV-10TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks.
Afferents to the primary startle circuit are essential for the elicitation and modulation of the ... more Afferents to the primary startle circuit are essential for the elicitation and modulation of the acoustic startle reflex (ASR). In the rat, cochlear root neurons (CRNs) comprise the first component of the acoustic startle circuit and play a crucial role in mediating the ASR. Nevertheless, the neurochemical pattern of their afferents remains unclear. To determine the distribution of excitatory and inhibitory inputs, we used confocal microscopy to analyze the immunostaining for vesicular glutamate and GABA transporter proteins (VGLUT1 and VGAT) on retrogradely labeled CRNs. We also used reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry to detect and localize specific neurotransmitter receptor subunits in the cochlear root. Our results show differential distributions of VGLUT1-and VGATimmunoreactive endings around cell bodies and dendrites. The RT-PCR data showed a positive band for several ionotropic glutamate receptor subunits, M1-M5 muscarinic receptor subtypes, the glycine receptor ␣1 subunit (GlyR␣1), GABA A , GABA B , and subunits of ␣2 and -noradrenergic receptors. By immunohistochemistry, we confirmed that CRN cell bodies exhibit positive immunoreaction for the glutamate receptor (GluR) 3 and NR1 GluR subunits. Cell bodies and dendrites were also positive for M2 and M4, and GlyR␣1. Other subunits, such as GluR1 and GluR4 of the AMPA GluRs, were observed in glial cells neighboring unlabeled CRN cell bodies. We further confirmed the existence of noradrenergic afferents onto CRNs from the locus coeruleus by combining tyrosine hydroxylase immunohistochemistry and tract-tracing experiments. Our results provide valuable information toward understanding how CRNs might integrate excitatory and inhibitory inputs, and hence how they could elicit and modulate the ASR.
We report on the γ-ray activity of the high-synchrotron-peaked BL Lacertae object Markarian 421 (... more We report on the γ-ray activity of the high-synchrotron-peaked BL Lacertae object Markarian 421 (Mrk 421) during the first 1.5 years of Fermi operation, from 2008 August 5 to 2010 March 12. We find that the Large Area Telescope (LAT) γ-ray spectrum above 0.3 GeV can be well described by a power-law function with photon index Γ = 1.78 ± 0.02 and average photon flux F(> 0.3 GeV) = (7.23 ± 0.16) × 10-8 ph cm-2 s-1. Over this time period, the Fermi-LAT spectrum above 0.3 GeV was evaluated on seven-day-long time intervals, showing significant variations in the photon flux (up to a factor ~3 from the minimum to the maximum flux) but mild spectral variations. The variability amplitude at X-ray frequencies measured by RXTE/ASM and Swift/BAT is substantially larger than that in γ-rays measured by Fermi-LAT, and these two energy ranges are not significantly correlated. We also present the first results from the 4.5 month long multifrequency campaign on Mrk 421, which included the VLBA, Swift, RXTE, MAGIC, the F-GAMMA, GASP-WEBT, and other collaborations and instruments that provided excellent temporal and energy coverage of the source throughout the entire campaign (2009 January 19 to 2009 June 1). During this campaign, Mrk 421 showed a low activity at all wavebands. The extensive multi-instrument (radio to TeV) data set provides an unprecedented, complete look at the quiescent spectral energy distribution (SED) for this source. The broadband SED was reproduced with a leptonic (one-zone synchrotron self-Compton) and a hadronic model (synchrotron proton blazar). Both frameworks are able to describe the average SED reasonably well, implying comparable jet powers but very different characteristics for the blazar emission site.
Background : The RING finger proteins function in a variety of fundamental cellular processes. Th... more Background : The RING finger proteins function in a variety of fundamental cellular processes. The products of some members of the Polycomb group (PcG) bear ring finger domains and are defined as a subclass of RING finger proteins. Among them are Drosophila posterior sex combs and suppressor 2 of zeste, whose RING fingers are conserved in vertebrate PcG proteins Mel18 and Bmi1.
Many states and hundreds of local municipalities have passed zoning laws prohibiting sex offender... more Many states and hundreds of local municipalities have passed zoning laws prohibiting sex offenders from living within close proximity to schools, parks, playgrounds, day care centers, and other places where children congregate. The purpose of this study was to investigate the positive and negative, intended and unintended consequences of residence restrictions on sex offenders. Results indicate that residence restrictions create housing instability for many offenders and limited accessibility to employment opportunities, social services, and social support. Young adult offenders were especially impacted because residence restrictions limited affordable housing options and often prevented them from living with family members. Implications for policy development and implementation are discussed.
Cochlear root neurons (CRNs) provide short-latency acoustic inputs to the caudal pontine reticula... more Cochlear root neurons (CRNs) provide short-latency acoustic inputs to the caudal pontine reticular nucleus that elicit an acoustic startle reflex (ASR). Auditory prepulse inhibition (PPI) of the acoustic startle response is the reduction in ASR magnitude that is observed when a strong acoustic startling stimulus (pulse) is shortly preceded by a weak sound (prepulse). It has been suggested that a short descending auditory pathway conveys auditory prepulses to the level of the CRNs to mediate the inhibition of ASR. However, no electrophysiological data is available to confirm such inhibition. We here investigated the effects of auditory prepulses on the neuronal activity of CRNs using extracellular recordings in vivo from single CRNs. Our results show that CRN responses are strongly inhibited by auditory prepulses. As occurs in the behavioral paradigm, the inhibition of the CRN responses depended on parameters of the auditory prepulse, such as intensity and interstimulus interval, showing their strongest inhibition at high intensity level and short interstimulus intervals. Furthermore, we tested the auditory PPI on the activity of different neuron types in the ventral cochlear nucleus. Of all neuron types tested, only CRNs exhibited a strong attenuation of activity. Our results corroborate our previous hypothesis that CRNs might be involved in the neural circuit of the inhibition of the ASR and suggest that several neuronal pathways participate in that circuit.
... Page 4. 148 María del Carmen Vergara Quintero, Consuelo Vélez Álvarez, José Armando Vidarte C... more ... Page 4. 148 María del Carmen Vergara Quintero, Consuelo Vélez Álvarez, José Armando Vidarte Claros, José Orlando Nieto Ramírez ... o Comprender lo que dicen los jóvenes acerca del riesgo, las prácticas relacionadas y el sentido que le dan a esas prácticas. ...
There are the theories for exploring Solar system formation in accord Titius-Bode's low: electrom... more There are the theories for exploring Solar system formation in accord Titius-Bode's low: electromagnetic theories (Birkeland (1912), Alfven (1942)), gravitational theories (Schmidt (1944), Woolfson (1964), Safronov (1969), Dole (1970)), nebular theories (Weizsaecker (1943), Kuiper (1949), Nakano (1970)) [1]-[3]. In spite of great number of work aimed to exploring formation of the Solar system, however, the mentioned theories were not able to explain all phenomena. In this connection the statistical theory for a cosmological body forming (so-called the spheroidal body model) has been proposed in [4]-[11]. Within the framework of this theory, bodies have fuzzy outlines and are represented by means of spheroidal forms. In the work [6], which is a continuation of the papers [4], [5], it has been investigated a slowly evolving in time process of a gravitational compression of a spheroidal body close to an unstable equilibrium state. In the papers [7],[8]the equation of motion of particles inside the weakly gravitating spheroidal body modeled by means of an ideal liquid has been obtained. Using Schwarzschild's and Kerr's metrics a consistency of the proposed statistical model with the general relativity has been shown in [12]. The proposed theory proceeds from the conception for forming a spheroidal body as a protoplanet from planetary nebula; it permits to derive the form of distribution functions for an immovable and rotating spheroidal body [4]-[6],[10]-[13] as well as their density masses (gravitational potentials and strengths) and also to find the distribution function of specific angular momentum of the rotating uniformly spheroidal body [13],[14]. Using the specific angular momentum distribution function this work considers a gas- dust protoplanetary cloud as a rotating and gravitating spheroidal body. Because the specific angular momenta are averaged during conglomeration process the specific angular momenta for a planets of Solar system is found. As a result a new low for Solar system planetary distances is derived (it generalizes the well-known Schmidt low). The new low gives a very good estimation of real planetary distances in Solar system (the relative error of estimation is 0%; absolute error of estimation is 0,5% besides its maximal value is equal to 5% for Earth and Pluto). This low has been applied also to estimation of Jupiter's satellities distances in this work. References: [1] M.M.Nieto, The Tutius-Bode low of planetary distances: its his-tory and theory. Pergamon: Oxford, New York et., 1972. [2] V.S. Safronov, Evolution of Protoplanetary cloud and the formation of the Earth and planets. 1969, Moscow, Nauka, (in Russian); NASA Tech. Transl. F-677, Washington, D.C. 1972. [3] A.V. Vityazev, G.V. Pechrnikova and V.S.Safronov, The Terrestrial planets: origin and early evolution. 1990. Moscow, Nauka (in Russian) [4] A.M.Krot, Achievement in Modern Radioelectronics (Special issue "Cosmic Radiophysics", Moscow), no.8, pp.66-81, 1996 (in Russian). [5] A.M.Krot, Proc. SPIE's 13th Annual Intern.Symp. "AeroSense", vol.3710, pp.1248-1259, Orlando, Florida, USA, April 5-9, 1999. [6] A.M.Krot, Proc. SPIE's 14th Annual Intern.Symp. "AeroSense", vol.4038, pp.1318-1329, Orlando, Florida, USA, April 24-28, 2000. [7] A.M.Krot, Proc. SPIE's 15th Annual Intern. Symposium "AeroSense", vol.4394, pp.1271-1282, Orlando, Florida, USA, April 16-20, 2001. [8] A.M.Krot, Proc. 53rd Intern. Astronautical Congress: The World Space Congress-2002, Houston, Texas, USA, October 10-19, 2002, Preprint IAC-02-J.P.01. - 11 p. [9] A.M.Krot, Proc. 34th Scientific Assembly of the Committee on Space Research (COSPAR)- The 2nd World Space Congress (WSC- 2002), October 10-19, 2002,Houston, Texas, USA. [10] A.M.Krot, Proc. of EGS- AGU-EUG Joint Assembly, Nice, France, April 6-11, 2003, Geophysical Research Abstracts, vol.5, EAE03-À-05568, 2003. [11] A.M. Krot, Proc. of 54 Intern. Astronautical Congress (IAC), September 29-October 3, 2003, Bremen, Germany, Preprint IAC-03-J.1.08. -11p. [12] A.M.Krot , Proc. of 35th COSPAR Scientific Assembly, Paris, France, July 18-25, 2004, Abstract-Nr. COSPAR 04-A-00162. [13] A.Krot, Proc. EGU- 2nd General Assembly, Vienna, Austria, April 24-29, 2005, Geophysical Research Abstracts, vol.7, EGU05-A-04550, 2005; SRef-ID: 1607-7962/gra/. [14] A.Krot Proc. EGU- General Assembly, Vienna, Austria, April 02- 07, 2006, Geophysical Research Abstracts, vol.8, EGU06-A-00216, 2006; SRef-ID: 1607-7962/gra/. 2
The presence of proto-oncogene mutations at codons 12, 13 and 61 of the Ha-, Ki-, and N-ras in pr... more The presence of proto-oncogene mutations at codons 12, 13 and 61 of the Ha-, Ki-, and N-ras in primary head and neck squamous cell carcinoma are analysed in this study.
En este documento se evalúa y analiza la relación entre las regalías directas y las coberturas mí... more En este documento se evalúa y analiza la relación entre las regalías directas y las coberturas mínimas alcanzadas por los municipios productores de petróleo para el periodo 2007-2008; mediante la metodología del análisis envolvente de datos. Esta metodología ha sido implementada en diferentes estudios que evalúan la eficiencia en la gestión gubernamental, sin embargo en Colombia no existe evidencia de su utilización en la gestión de las transferencias por explotación de petróleo. Los resultados obtenidos evidencian una eficiencia técnica pura promedio del 24% para el 2007 y 19.6% para el 2008, en los cuatro modelos analizados, de los que se concluye que son pocos los municipios que presentan un desempeño eficiente en cuanto a la gestión de las regalías.
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi oper... more We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average LAT gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of 2), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3GeV. In this paper, we also present the first results from the 4.5-month-long multifrequency campaign (2009 March 15 - August 1) on Mrk 501, which included the VLBA, Swift, RXTE, MAGIC and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton model. In the framework of this model, we find that the dominant emission region is characterized by a size <~ 0.1 pc (comparable within a factor of few to the size of the partially-resolved VLBA core at 15-43 GHz), and that the total jet power (~10^{44} erg s^{-1}) constitutes only a small fraction (~10^{-3}) of the Eddington luminosity. The energy distribution of the freshly-accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3GeV-10TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks.
Afferents to the primary startle circuit are essential for the elicitation and modulation of the ... more Afferents to the primary startle circuit are essential for the elicitation and modulation of the acoustic startle reflex (ASR). In the rat, cochlear root neurons (CRNs) comprise the first component of the acoustic startle circuit and play a crucial role in mediating the ASR. Nevertheless, the neurochemical pattern of their afferents remains unclear. To determine the distribution of excitatory and inhibitory inputs, we used confocal microscopy to analyze the immunostaining for vesicular glutamate and GABA transporter proteins (VGLUT1 and VGAT) on retrogradely labeled CRNs. We also used reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry to detect and localize specific neurotransmitter receptor subunits in the cochlear root. Our results show differential distributions of VGLUT1-and VGATimmunoreactive endings around cell bodies and dendrites. The RT-PCR data showed a positive band for several ionotropic glutamate receptor subunits, M1-M5 muscarinic receptor subtypes, the glycine receptor ␣1 subunit (GlyR␣1), GABA A , GABA B , and subunits of ␣2 and -noradrenergic receptors. By immunohistochemistry, we confirmed that CRN cell bodies exhibit positive immunoreaction for the glutamate receptor (GluR) 3 and NR1 GluR subunits. Cell bodies and dendrites were also positive for M2 and M4, and GlyR␣1. Other subunits, such as GluR1 and GluR4 of the AMPA GluRs, were observed in glial cells neighboring unlabeled CRN cell bodies. We further confirmed the existence of noradrenergic afferents onto CRNs from the locus coeruleus by combining tyrosine hydroxylase immunohistochemistry and tract-tracing experiments. Our results provide valuable information toward understanding how CRNs might integrate excitatory and inhibitory inputs, and hence how they could elicit and modulate the ASR.
We report on the γ-ray activity of the high-synchrotron-peaked BL Lacertae object Markarian 421 (... more We report on the γ-ray activity of the high-synchrotron-peaked BL Lacertae object Markarian 421 (Mrk 421) during the first 1.5 years of Fermi operation, from 2008 August 5 to 2010 March 12. We find that the Large Area Telescope (LAT) γ-ray spectrum above 0.3 GeV can be well described by a power-law function with photon index Γ = 1.78 ± 0.02 and average photon flux F(> 0.3 GeV) = (7.23 ± 0.16) × 10-8 ph cm-2 s-1. Over this time period, the Fermi-LAT spectrum above 0.3 GeV was evaluated on seven-day-long time intervals, showing significant variations in the photon flux (up to a factor ~3 from the minimum to the maximum flux) but mild spectral variations. The variability amplitude at X-ray frequencies measured by RXTE/ASM and Swift/BAT is substantially larger than that in γ-rays measured by Fermi-LAT, and these two energy ranges are not significantly correlated. We also present the first results from the 4.5 month long multifrequency campaign on Mrk 421, which included the VLBA, Swift, RXTE, MAGIC, the F-GAMMA, GASP-WEBT, and other collaborations and instruments that provided excellent temporal and energy coverage of the source throughout the entire campaign (2009 January 19 to 2009 June 1). During this campaign, Mrk 421 showed a low activity at all wavebands. The extensive multi-instrument (radio to TeV) data set provides an unprecedented, complete look at the quiescent spectral energy distribution (SED) for this source. The broadband SED was reproduced with a leptonic (one-zone synchrotron self-Compton) and a hadronic model (synchrotron proton blazar). Both frameworks are able to describe the average SED reasonably well, implying comparable jet powers but very different characteristics for the blazar emission site.
Background : The RING finger proteins function in a variety of fundamental cellular processes. Th... more Background : The RING finger proteins function in a variety of fundamental cellular processes. The products of some members of the Polycomb group (PcG) bear ring finger domains and are defined as a subclass of RING finger proteins. Among them are Drosophila posterior sex combs and suppressor 2 of zeste, whose RING fingers are conserved in vertebrate PcG proteins Mel18 and Bmi1.
Uploads
Papers by Orlando Nieto