Anandamidum
| Cognitores | |
|---|---|
| ChemSpider | 4445241 |
| PubChem | 5281969 |
| Natura chemica | |
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| Formula summarum | C 22H 37NO 2 |
| Massa molaris | 347.53 g/mol |
Anandamidum vel N-arachidonoylaethanolaminum (AEA) est neurotransmissor et acidum adipatum ab acido arachidonico, uno acidorum adipatorum omega-6 essentialium, derivatum. Pars nominis prima de Lingua Sanscrita (ananda = felicitas) Lingua Sanscrita.
Effectus anandamidi cum praesentia receptoriorum cannabinoideorum nexi sunt. Putatur quoque anandamido effectus in morbis mentis esse[1].
Natura chemica
[recensere | fontem recensere]Compositum est anandamidum longa ex molecula acidi arachidonici per amino secundario cum aaethanolo (aeathanolamino) coniunctum. Nomen IUPAC est (5Z,8Z,11Z,14Z)-N-(2-hydroxy-aethyl)-icosa-5,8,11,14-tetraenamidum.
Biochemia
[recensere | fontem recensere]In hominibus synthesis anandamidi acidum arachidonicum requirit, ex quoN-arachidonoyl phosphatidylethanolaminum (NAPE) generatur.
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Aminum secundarium -
Aethanolaminum -
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Aminum primarium
Notae
[recensere | fontem recensere]- ↑ Gaetani S., Dipasquale P., Romano A., Righetti L., Cassano T., Piomelli D., Cuomo V. (2009). "The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs". International review of neurobiology 85: 57-72
Bibliographia
[recensere | fontem recensere]- Mechoulam R., Fride E.: The unpaved road to the endogenous brain cannabinoid ligands, the anandamides in “Cannabinoid Receptors” (ed. R. Pertwee), Academic Press, London. Pp. 233-258 (1995).