Papers by Amani Ahmed Marzouk
Bulletin of Pharmaceutical Sciences. Assiut, 2006
Three major iridoids; viz. plumieride, protoplumericin A and plumieride acid were isolated from t... more Three major iridoids; viz. plumieride, protoplumericin A and plumieride acid were isolated from the bark and leaves of Plumeria alba L. Protoplumericin A and plumieride acid are reported for the first time from the titled plant. These compounds were identified through different chemical and spectroscopic methods. They displayed distinct activity against some pathogenic bacteria and fungi.
Pharmazie
Two new metabolites were isolated from the biotransformation reaction of parthenin by Beauveria b... more Two new metabolites were isolated from the biotransformation reaction of parthenin by Beauveria bassiana ATCC 7159 along with the known naturally occurring sesquiterpene lactones hymenolin and dihydrocoronopilin. The new metabolites: are 3beta,4beta,6beta-trihydroxy-10alphaH,11alpha-methyl-ambrosa-1 -en-12-oic acid-gamma-lactone and 3alpha,6beta-dihydroxy-4beta-hydroperoxy-10alphaH, 11alpha-methyl-ambrosa-1-en-12-oic acid-gamma-lactone. The structure elucidation of these compounds was achieved by different spectroscopic methods.
Six compounds were isolated from methanolic extracts of the leaf and the bark of Tipuana tipu (Be... more Six compounds were isolated from methanolic extracts of the leaf and the bark of Tipuana tipu (Benth.) Lillo growing in Egypt. The isolated compounds were identified as 1-Nonadecanol (1), β-sitosterol (2), Alpinumisoflavone (3), β-sitosterol glucoside (4), Protocatechualdehyde (5) and Protocatechuic acid (6), based on different spectroscopic data (UV, IR, NMR and MS). This is the first report to indicate the isolation of compounds 1 & 3-6 from Tipuana tipu. Compound 1 is isolated for the first time from family Fabaceae. Compounds 2 and 3 showed a promising anticancer activity, while compound 5 displayed a remarkable in vivo anti-inflammatory activity compared to indomethacin.
Zeitschrift für Naturforschung C, 2014
Microbial metabolism of danazol (17α-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17ß-ol) by Beauveria b... more Microbial metabolism of danazol (17α-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17ß-ol) by Beauveria bassiana ATCC 7159 and Glyocladium viride ATCC 10097 afforded four metabolites. The isolated metabolites were identified by different spectroscopic techniques as 6ß- hydroxy danazol, which is a not yet reported danazol metabolite, 17ß-hydroxy-17α-pregn-4-en- 20-yn-3-one (ethisterone) and 17ß-hydroxy-2α-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2α- hydroxymethyl ethisterone), which represent the major danazol metabolites detected in human urine. The last metabolite, 6ß,17ß-dihydroxy-2-(hydroxymethyl)-17α-pregna-1,4-dien-20-yn-3-one, is also a minor human metabolite, for which the NMR data are described here for the first time. The metabolites were isolated in quantities that allowed their use for direct comparison in routine doping analysis
Zeitschrift für Naturforschung C, 2009
Six triterpene acids identified as betulinic, oleanolic, ursolic, 3-epimaslinic, alphitolic and e... more Six triterpene acids identified as betulinic, oleanolic, ursolic, 3-epimaslinic, alphitolic and euscaphic acids have been isolated from a dichloromethane extract of hairy root cultures of Ocimum basilicum L. (Lamiaceae). These cultures were obtained by genetic transformation using Agrobacterium rhizogenes. The extract as well as the isolated compounds were evaluated for their hepatoprotective activity by measuring their effect on the oxidative stress status of liver, induced by carbon tetrachloride, in albino rats and in liver homogenate in vitro. All tested compounds displayed hepatoprotective activity comparable to oleanolic and ursolic acids.
Journal of Cosmetics, Dermatological Sciences and Applications, 2014
Corncobs could serve as a substrate for citric acid production using solid state fermentation tec... more Corncobs could serve as a substrate for citric acid production using solid state fermentation technique. The culture optimization concerning substrate concentration, culture duration, pH, temperature and substrate hydrolysis was carried out for maximum productivity of citric acid. Under the optimized conditions, 48.4 g of citric acid was produced from 1 kg dry corncobs. Biological evaluation was carried out for citric acid such as melanin synthesis inhibitory, anti-allergy, anti-bacterial, and hyaluronic acid production activities. The results showed that citric acid has potent melanin inhibitory activity, good inhibition for β-hexosaminidase release and potent stimulatory effect for the production of hyaluronic acid. These activities (melanin synthesis inhibitory, anti-allergy and hyaluronic acid productive activities) of citric acid have been reported for the first time.
Natural Product Research, 2015
Machaerium, in the family Fabaceae, predominantly is a genus of a Neotropical distribution of tre... more Machaerium, in the family Fabaceae, predominantly is a genus of a Neotropical distribution of trees, shrubs, and lianas occurring from southern Mexico to Brazil and northern Argentina and as far as South America. Several Machaerium species are widely used in traditional medicine and are considered to have multiple medicinal properties. This review aims to provide up-to-date and comprehensive information on the taxonomy, phytochemistry, traditional uses and biological activities of plants in the genus Machaerium.
Natural Product Research, 2014
A new acylated kaempferol glycoside, kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 6)-O-[β-d-glucopyran... more A new acylated kaempferol glycoside, kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 6)-O-[β-d-glucopyranosyl-(1 → 2)-4-O-acetyl-α-l-rhamnopyranosyl-(1 → 2)]-β-d-galactopyranoside, has been isolated from the leaves of Tipuana tipu (Benth.) Lillo growing in Egypt, along with three known flavonol glycosides, kaempferol 3-O-rutinoside, quercetin 3-O-rutinoside (rutin) and kaempferol 3-O-[α-l-rhamnopyranosyl-(1 → 6)]-[α-l-rhamnopyranosyl-(1 → 2]-β-d-glucopyranoside. Structure elucidation was achieved through different spectroscopic methods. Structure relationship with anti-inflammatory activity using carrageenin-induced rat paw oedema model is discussed.
Phytochemistry, 2010
Biotransformation of 18b-glycyrrhetinic acid, using Absidia pseudocylinderospora ATCC 24169, Glio... more Biotransformation of 18b-glycyrrhetinic acid, using Absidia pseudocylinderospora ATCC 24169, Gliocladium viride ATCC 10097 and Cunninghamella echinulata ATCC 8688a afforded seven metabolites, which were identified by different spectroscopic techniques (1 H, 13 C NMR, DEPT, 1 H-1 H COSY, HMBC and HMQC). Three of these metabolites, viz. 15a-hydroxy-18a-glycyrrhetinic acid, 13b-hydroxy-7a,27-oxy-12-dihydro-18b-glycyrrhetinic acid and 1a-hydroxy-18b-glycyrrhetinic acid are new. The 13 C NMR data and full assignment for the known metabolite 7b, 15a-dihydroxy-18b-glycyrrhetinic acid are described here for the first time. The major metabolites were evaluated for their hepatoprotective activity using different in vitro and in vivo models. These included protection against FeCl 3 /ascorbic acid-induced lipid peroxidation of normal mice liver homogenate, induction of nitric oxide (NO) production in rat macrophages and in vivo hepatoprotection against CCl 4-induced hepatotoxicity in albino mice.
Genetic Transformation, 2011
Natural Product Research, 2015
Investigation of the aerial parts of Vernonia leopoldii (Sch. Bip.) Vatke afforded a new lanostan... more Investigation of the aerial parts of Vernonia leopoldii (Sch. Bip.) Vatke afforded a new lanostane-type triterpene along with known hirsutinolide-type sesquiterpene lactones and flavonoid glycosides, all are identified for the first time in this species. The new compound was identified as lanost-3β, 23S-dihydroxy-22(31)-ene. The structures of the isolated compounds were elucidated based on spectroscopic evidence. The hirsutinolides and the triterpene were evaluated for their cytotoxicity against four human cancer cell lines using MTT assay.
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Papers by Amani Ahmed Marzouk