Purpose: To assess the 1-year efficacy and safety of the implantation of two second-generation tr... more Purpose: To assess the 1-year efficacy and safety of the implantation of two second-generation trabecular micro-bypass stents (iStent Inject Ò) with concomitant cataract surgery in various subtypes and severities of glaucoma. Methods: This single-surgeon, consecutive case series from a Canadian academic ophthalmol-ogy center included subjects with cataract, glaucoma, and the need to reduce intraocular pressure (IOP) and/or medications. The 12-month outcomes included mean IOP and medication burden as well as the proportions of eyes with IOP B 18, B 15, and B 12 mmHg compared to baseline. Other measures included corrected distance visual acuity (CDVA), cup-to-disc ratio (CDR), visual field mean deviation (VF MD), retinal nerve fiber layer (RNFL) thickness, ganglion cell inner plexiform layer (GCIPL) thickness, and adverse events. Results: In 118 eyes, mean IOP reduced from 17.00 ± 3.82 mmHg preoperatively to 13.97 ± 2.65 mmHg at the 12-month follow-up mark (17.8% reduction, p \ 0.001), and mean medication burden decreased from 2.31 ± 1.33 preoperatively to 1.03 ± 1.10 medications (56% reduction, p \ 0.001). After 12 months, 93% of eyes achieved IOP B 18 mmHg (versus 69% preoperatively), 70% of eyes achieved IOP B 15 mmHg (versus 42% preoperatively), and 29% of eyes achieved IOP B 12 mmHg (versus 7% preoperatively). For all eyes, topical medications were either maintained or decreased from baseline, with C 1 medication eliminated from the preoperative regimen for 83% of eyes and C 2 medications eliminated for 36% of eyes. Visual acuity improved significantly , consistent with expectations for cataract surgery, while CDR, VF MD, and RNFL and GCIPL thicknesses remained stable. Safety was favorable, with no intraoperative complications and few transient adverse events postoperatively. Conclusion: iStent Inject implantation with cataract surgery safely reduced IOP and medication burden in a real-world clinical population with mild to severe glaucoma, and Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.9762590.
Gaucher disease (GD) results from a deficiency of glucocerebrosidase activity and the subsequent ... more Gaucher disease (GD) results from a deficiency of glucocerebrosidase activity and the subsequent accumulation of the enzyme's metabolites, principally glucosylsphingosine and glucosylceramide. There are three principal forms: Type I, which is the most common, is usually considered non-neuronopathic.
Background and Aim: Predisposing factors place certain individuals at higher risk for insomnia, e... more Background and Aim: Predisposing factors place certain individuals at higher risk for insomnia, especially in the presence of precipitating conditions such as stressful life events. Sleep spindles have been shown to play an important role in the preservation of sleep continuity. Lower spindle density might thus constitute an objective predisposing factor for sleep reactivity to stress. The aim of this study was therefore to evaluate the relationship between baseline sleep spindle density and the prospective change in insomnia symptoms in response to a standardized academic stressor.
Objective: The aim of this study was to evaluate whether high-frequency heart rate variability (H... more Objective: The aim of this study was to evaluate whether high-frequency heart rate variability (HF-HRV) during waking restfulness and during worry predicts increases in sleep disturbances in response to a stressful life event.
Aims: Phenformin, resveratrol and AICAR stimulate the energy sensor 59-AMP activated kinase (AMPK... more Aims: Phenformin, resveratrol and AICAR stimulate the energy sensor 59-AMP activated kinase (AMPK) and inhibit the first step of ribosome biogenesis, de novo RNA synthesis in nucleoli. Nucleolar activities are relevant to human health, because ribosome production is crucial to the development of diabetic complications. Although the function of nucleoli relies on their organization, the impact of AMPK activators on nucleolar structures is not known. Here, we addressed this question by examining four nucleolar proteins that are essential for ribosome biogenesis.
Purpose: To assess the 1-year efficacy and safety of the implantation of two second-generation tr... more Purpose: To assess the 1-year efficacy and safety of the implantation of two second-generation trabecular micro-bypass stents (iStent Inject Ò) with concomitant cataract surgery in various subtypes and severities of glaucoma. Methods: This single-surgeon, consecutive case series from a Canadian academic ophthalmol-ogy center included subjects with cataract, glaucoma, and the need to reduce intraocular pressure (IOP) and/or medications. The 12-month outcomes included mean IOP and medication burden as well as the proportions of eyes with IOP B 18, B 15, and B 12 mmHg compared to baseline. Other measures included corrected distance visual acuity (CDVA), cup-to-disc ratio (CDR), visual field mean deviation (VF MD), retinal nerve fiber layer (RNFL) thickness, ganglion cell inner plexiform layer (GCIPL) thickness, and adverse events. Results: In 118 eyes, mean IOP reduced from 17.00 ± 3.82 mmHg preoperatively to 13.97 ± 2.65 mmHg at the 12-month follow-up mark (17.8% reduction, p \ 0.001), and mean medication burden decreased from 2.31 ± 1.33 preoperatively to 1.03 ± 1.10 medications (56% reduction, p \ 0.001). After 12 months, 93% of eyes achieved IOP B 18 mmHg (versus 69% preoperatively), 70% of eyes achieved IOP B 15 mmHg (versus 42% preoperatively), and 29% of eyes achieved IOP B 12 mmHg (versus 7% preoperatively). For all eyes, topical medications were either maintained or decreased from baseline, with C 1 medication eliminated from the preoperative regimen for 83% of eyes and C 2 medications eliminated for 36% of eyes. Visual acuity improved significantly , consistent with expectations for cataract surgery, while CDR, VF MD, and RNFL and GCIPL thicknesses remained stable. Safety was favorable, with no intraoperative complications and few transient adverse events postoperatively. Conclusion: iStent Inject implantation with cataract surgery safely reduced IOP and medication burden in a real-world clinical population with mild to severe glaucoma, and Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.9762590.
Gaucher disease (GD) results from a deficiency of glucocerebrosidase activity and the subsequent ... more Gaucher disease (GD) results from a deficiency of glucocerebrosidase activity and the subsequent accumulation of the enzyme's metabolites, principally glucosylsphingosine and glucosylceramide. There are three principal forms: Type I, which is the most common, is usually considered non-neuronopathic.
Background and Aim: Predisposing factors place certain individuals at higher risk for insomnia, e... more Background and Aim: Predisposing factors place certain individuals at higher risk for insomnia, especially in the presence of precipitating conditions such as stressful life events. Sleep spindles have been shown to play an important role in the preservation of sleep continuity. Lower spindle density might thus constitute an objective predisposing factor for sleep reactivity to stress. The aim of this study was therefore to evaluate the relationship between baseline sleep spindle density and the prospective change in insomnia symptoms in response to a standardized academic stressor.
Objective: The aim of this study was to evaluate whether high-frequency heart rate variability (H... more Objective: The aim of this study was to evaluate whether high-frequency heart rate variability (HF-HRV) during waking restfulness and during worry predicts increases in sleep disturbances in response to a stressful life event.
Aims: Phenformin, resveratrol and AICAR stimulate the energy sensor 59-AMP activated kinase (AMPK... more Aims: Phenformin, resveratrol and AICAR stimulate the energy sensor 59-AMP activated kinase (AMPK) and inhibit the first step of ribosome biogenesis, de novo RNA synthesis in nucleoli. Nucleolar activities are relevant to human health, because ribosome production is crucial to the development of diabetic complications. Although the function of nucleoli relies on their organization, the impact of AMPK activators on nucleolar structures is not known. Here, we addressed this question by examining four nucleolar proteins that are essential for ribosome biogenesis.
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