Lead Character is Blind/Deaf/Mute/Physically Disabled in Romance/Family-oriented story
Manga
Lead Character in romance/family-oriented story that are Blind, Deaf, Mute, or hold other Physical Disability (Wheelchair, Amputated Limb) for a large portion, if not permanently, of the story.
Mind-reading Lead Character in Romance/Family Oriented Story
https://myanimelist.net/stacks/37295
Misunderstood Leads in modern romance/school
https://myanimelist.net/stacks/36991
Lead Characters misunderstood/adored by people around them in fantasy/isekai
https://myanimelist.net/stacks/36957
Additional (currently no MyAnimeList page):
-(Japanese Webtoon) Kyouai to Junai / Between Yearning and Obsession (Mute Female Protagonist)
-(Manhwa) I Grabbed the Leash of the Blind Beast (Blind Male Lead)
-(Manhwa) Just Kill Me Now / No More Regrets, Just Kill Me (Mute Female Lead)
-(Manga) Party wo Oidasareta Motoyushashibono D Rank Bokensha Koe wo Nakushita SSS Rank Mahotsukai Bishojo wo Hiro Soshite Iyasareru / How the SS-Rank Sorceress Who Lost Her Voice Healed a D-Rank Adventurer Who Lost His Confidence (Mute Female Lead)
Mind-reading Lead Character in Romance/Family Oriented Story
https://myanimelist.net/stacks/37295
Misunderstood Leads in modern romance/school
https://myanimelist.net/stacks/36991
Lead Characters misunderstood/adored by people around them in fantasy/isekai
https://myanimelist.net/stacks/36957
Additional (currently no MyAnimeList page):
-(Japanese Webtoon) Kyouai to Junai / Between Yearning and Obsession (Mute Female Protagonist)
-(Manhwa) I Grabbed the Leash of the Blind Beast (Blind Male Lead)
-(Manhwa) Just Kill Me Now / No More Regrets, Just Kill Me (Mute Female Lead)
-(Manga) Party wo Oidasareta Motoyushashibono D Rank Bokensha Koe wo Nakushita SSS Rank Mahotsukai Bishojo wo Hiro Soshite Iyasareru / How the SS-Rank Sorceress Who Lost Her Voice Healed a D-Rank Adventurer Who Lost His Confidence (Mute Female Lead)

Manga, 2 vol, 2020
Me:-
Author:-
Disabled on wheelchair, Female Lead
Has an Anime adaption.
Has an Anime adaption.

Manga, ? vol, 2022
Me:-
Author:7
Blind, Female Protagonist

Manga, 13 vol, 2020
Me:-
Author:8
Mute, Female Protagonist

Manga, ? vol, 2018
Me:-
Author:-
Mute, Female Supporting Lead
Adapted from a Light Novel series.
Adapted from a Light Novel series.

Manga, 2 vol, 2021
Me:-
Author:-
Blind, Female Protagonist

Manga, ? vol, 2021
Me:-
Author:-
Mute, Female Protagonist

Manga, ? vol, 2022
Me:-
Author:-
Blind, Female Protagonist

Manga, ? vol, 2022
Me:-
Author:-
Amputated Leg, Male Protagonist
Based on a recommended Visual Novel. Has an Anime adaption.
Based on a recommended Visual Novel. Has an Anime adaption.