Papers by Dr Doondi Phani Kumar Nagulavancha (Pharm D)
The Yale journal of biology and medicine
Pain has been a major concern of humankind since the ancient times, and it remains one of the mos... more Pain has been a major concern of humankind since the ancient times, and it remains one of the most important subjects of all health care professionals. Despite the obvious overwhelming clinical importance, the major advances in its diagnosis and therapy have been made only recently. "How do the sensory apparatus of the body and system of signal transmission relate to pain of peripheral origin?" is the topic of discussion. To do this, it is important to understand what constitutes the total pain experience. It consists of: 1) signal transduction at the peripheral receptor site, 2) signal conduction along the peripheral nerve, 3) pain modulation at the level of the spinal cord, 4) pain perception at the supraspinal site, and 5) the associated sensations, emotional reactions, and effective state. The signal transmission related to pain may be modified by various analgesic agents. Specific analgesic agent has a specific site of action which may be at peripheral receptors, at p...
International Journal of Current Pharmaceutical Research, 2022
Heart problem is a problem in the electrical signals in the heart. Electrical signals initiate a ... more Heart problem is a problem in the electrical signals in the heart. Electrical signals initiate a regular heartbeat that comes from the heart pacemaker, the sinoatrial node (SA), which is located at the top of the right atrium. Although the AV block is relative, the third-degree AV block is respectively rare. The incidence in the general population appears to be low, approximately 0.02% to 0.04 %. A 65-year-old male patient admitted in the hospital with chief complaints of giddiness with sweating and history of symptomatic AV-block with no chest pain, shortness of breath. Patient underwent surgery of Inserted temporary pacemaker, permanent pacemaker and D-Data direction register (DDDr). In clinical use, the adverse effects of QT-prolonging drugs can be checked by not exceeding the prescribed dose, withdrawing their use in patients with pre-existing cardiac disease, premature ventricular arrhythmias, and electrolyte imbalance such as hypokalemia. Simultaneous administration of drugs t...
Research Journal of Pharmacy and Technology, 2020
Asian Journal of Pharmaceutical and Clinical Research
Diabetes mellitus (DM) is not one disorder; it represents a series of metabolic conditions relate... more Diabetes mellitus (DM) is not one disorder; it represents a series of metabolic conditions related to hyperglycemia and caused by defects in hormone secretion and hormone action. Exposure to chronic hyperglycemia may result in microvascular complications in the retina (diabetic retinopathy), kidney (diabetic nephropathy), neuron (diabetic-neuropathy), skin, foot, and cardiac complications (stroke, hypertension…etc.). International Diabetes Federation estimates that 1.1 million children and adolescents aged 14–19 years have type one DM. Without interventions to halt the increase in diabetes, there will be at least 629 million people living with diabetes by 2045. In the body, white adipose tissue is the leading site for the storage of excess energy produced from the food intake in large quantities, of the development of insulin resistance (IR) and type 2 DM by the over intake of fatty acid in the body. It results in the accumulation of fatty acyl co-A (FA-CoA) within the myocytes. It ...
International Journal of Current Pharmaceutical Research
Objective: Rare cancers are creating a massive challenge to the world. It has associated with gen... more Objective: Rare cancers are creating a massive challenge to the world. It has associated with genetic mutations or socio-environmental factors, which includes genes, smoking, alcohol, ionizing radiation exposure, organic-inorganic chemicals, air and water pollution, viruses, and bacteria. When 15 cases per 1,00,000 people per year, we can consider it as a rare case as per the National Cancer Institute This study aim is the importance of antibiotics in various unique metastasis along with cytotoxic therapy at tertiary care hospital. Methods: The inclusion criteria of our study include a person who is suffering from rare metastasis at an early stage. We excluded the data that are those who are suffering from the typical type of cancers, multiple co-morbid conditions. This study was carried out the Prospective Cohort Study conducted between June 2018 to March 2020. Results: Number of 20 rare cancers we consider for final analysis, the overall antibiotics use in this study 18 antibiotic...
European journals of pharmaceutical science, 2019
On Asthma Patients At Tertiary Care Hospital To ascertain the knowledge of the patients regarding... more On Asthma Patients At Tertiary Care Hospital To ascertain the knowledge of the patients regarding their disease and the therapy, To provide pharmaceutical care pertaining to disease and use of inhalational devices to the study group, which is to be compared with the control group. Methodology: A Prospective, observational study was conducted in the Department of General Medicine in Manipal super specialty Hospital, Vijayawada, India. for a period of 6 months. Patients were also distinguished between an intervention and control group. Results: the decreased order of patient preference of using anti-asthmatic drugs. The males in Intervention group and females in control group are high compared to females in intervention and males in control group. Bronchodilators and anti-inflammatory agents are highly prescribed for the patients. Discussion: seasonal changes, air pollution, brooms and dusters of these self-assessment triggers are the main causes of asthma. and interventional group shows fast recovery compared with control group. Conclusion: The drug utilization pattern shows a good functioning of lungs and relives from the various problems. clinical pharmacists can provide better health care to the patients. Better interventions improve quality of life of patients.
Pain has been a major concern of humankind since the ancient times, and it remains one of the mos... more Pain has been a major concern of humankind since the ancient times, and it remains one of the most important subjects of all health care professionals. Despite the obvious overwhelming clinical importance, the major advances in its diagnosis and therapy have been made only recently. "How do the sensory apparatus of the body and system of signal transmission relate to pain of peripheral origin?" is the topic of discussion. To do this, it is important to understand what constitutes the total pain experience. It consists of: 1) signal transduction at the peripheral receptor site, 2) signal conduction along the peripheral nerve, 3) pain modulation at the level of the spinal cord, 4) pain perception at the supraspinal site, and 5) the associated sensations, emotional reactions, and affective state. The signal transmission related to pain may be modified by various analgesic agents. Specific analgesic agent has a specific site of action which may be at peripheral receptors, at peripheral nerves, at the level of the spinal cord, at supraspinal levels by activating descending inhibitory systems, or at more cephalad levels by reducing the affective component of pain.
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Papers by Dr Doondi Phani Kumar Nagulavancha (Pharm D)