Papers by Masatoshi Takeda
Journal of Alzheimer's disease : JAD, 2014
Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer... more Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using a well-characterized Japanese sample set, comprising 2,190 late-onset AD (LOAD) cases and 2,498 controls. We genotyped 10 non-synonymous variants (Q33X, Y38C, R47H, T66M, N68K, D87N, T96K, R98W, H157Y, and L211P) of TREM2 reported by Guerreiro et al. (2013) by means of the TaqMan and dideoxy sequencing methods. Only three variants, R47H, H157Y, and L211P, were polymorphic (range of minor allele frequency [MAF], 0.0002-0.0059); however, no significant association with LOAD was observed in these variants. Considering low MAF of variants examined and our study sample size, further genetic analysis with a larger sample set is needed to firmly evaluate whether or not TREM2 is associated with LOAD in Japanese.
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The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2014
In a previous report, we identified a novel molecule, SHATI/NAT8L, having an inhibitory effect on... more In a previous report, we identified a novel molecule, SHATI/NAT8L, having an inhibitory effect on methamphetamine (METH)-induced hyperlocomotion, sensitization, and conditioned place preference (CPP). SHATI/NAT8L attenuates the METH-induced increase in dopamine overflow in the nucleus accumbens (NAc) by promoting plasmalemmal and vesicular dopamine uptake. However, the biological functions of the protein remain unclear. In this study, we explored NAT8L-binding proteins using pull-down assays and identified a number of components of the adaptor protein (AP)-2 complex, which is a multimeric protein localized to the plasma membrane that functions to internalize cargo during clathrin-mediated endocytosis. To investigate whether NAT8L regulates the receptor localization to the cell surface, cell-surface dopamine D1 receptor in the NAc of Nat8l knockout (KO) mice was quantified. We found that dopamine D1 receptor on the cell surface was increased in the NAc of Nat8l KO mice compared with ...
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JAMA Psychiatry, 2014
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On May 1st, 2001, the Vermont Electric Power Company, Inc., (VELCO) placed a +133/41 MVA, 115 kV ... more On May 1st, 2001, the Vermont Electric Power Company, Inc., (VELCO) placed a +133/41 MVA, 115 kV STATCOM system on-line at the Essex Substation located near Burlington, VT, USA. The STATCOM, a flexible AC transmission system (FACTS) technology, was installed to provide dynamic voltage support and reactive compensation on the VELCO transmission system. The installation was part of a major
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Neuroscience letters, Jan 17, 2014
Hypofunction of the N-methyl-d-aspartate (NMDA) subtype of glutamate receptors may be involved in... more Hypofunction of the N-methyl-d-aspartate (NMDA) subtype of glutamate receptors may be involved in the pathophysiology of schizophrenia. Many studies have investigated peripheral NMDA receptor-related glutamatergic amino acid levels because of their potential as biological markers. Peripheral d-serine levels and the ratio of d-serine to total serine have been reported to be significantly lower in patients with schizophrenia than in controls. Peripheral d-serine levels and the d-/l-serine ratio have also been reported to significantly increase in patients with schizophrenia as their clinical symptoms improve from the time of admission to the time of discharge. In this study, we examined whether peripheral NMDA receptor-related glutamatergic amino acids levels were altered in patients with treatment-resistant schizophrenia compared to controls and whether these peripheral amino acids levels were altered by clozapine treatment. Twenty-two patients with treatment-resistant schizophrenia ...
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European Neurology, 1999
In order to investigate the underlying mechanism of ideomotor apraxia, we studied 9 patients who ... more In order to investigate the underlying mechanism of ideomotor apraxia, we studied 9 patients who could not mime using tools despite the ability to manipulate actual tools normally. In all the mime tasks, visually presented tools or model gestures by examiners were fundamentally ineffectual in improving the patients’ performances. Even the remarkable improvement demonstrated when using actual tools disappeared immediately
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Sensors, 2013
We have developed a real-time terahertz time-domain polarization analyzer by using 80-MHz repetit... more We have developed a real-time terahertz time-domain polarization analyzer by using 80-MHz repetition-rate femtosecond laser pulses. Our technique is based on the spinning electro-optic sensor method, which we recently proposed and demonstrated by using a regenerative amplifier laser system; here we improve the detection scheme in order to be able to use it with a femtosecond laser oscillator with laser pulses of a much higher repetition rate. This improvement brings great advantages for realizing broadband, compact and stable real-time terahertz time-domain polarization measurement systems for scientific and industrial applications.
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Psychiatry and Clinical Neurosciences, 2000
A review of the literature on comorbid eating disorder and factitious disorder reveals that they ... more A review of the literature on comorbid eating disorder and factitious disorder reveals that they are very rare. In this report the authors present the case of a 26-year-old Japanese female, who, in the midst of treatment for eating disorder, was found to be fabricating her physical symptoms, by injecting unclean water into her intravenous bottle. As a result she was diagnosed with factitious disorder.
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Psychiatry and Clinical Neurosciences, 2007
Musical hallucinations (MH) typically occur among elderly individuals and are associated with hea... more Musical hallucinations (MH) typically occur among elderly individuals and are associated with hearing impairment. The authors describe a patient with features of typical MH who was successfully treated with donepezil, a cholinesterase inhibitor, as a combination therapy and who has not shown any subsequent cognitive decline for approximately 5 years. The efficacy of donepezil in this patient indicates that age-dependent dysfunction of cholinergic neurons might be related to the development of MH.
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The Georgia Power Company (GPC), an affiliate of Southern Company, commission the 0 to +87 Mvar L... more The Georgia Power Company (GPC), an affiliate of Southern Company, commission the 0 to +87 Mvar Laurens County static VAR compensator (SVC) in May of 2005. This paper presents the Dublin, Georgia area transmission network, the requirements for voltage support, the planning and engineering studies used in rating the SVC and verifying its performance, and provides an overview of the
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The European Journal of Psychiatry, 2010
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… and Exhibition 2002 …, 2002
SDG&E Talega STATCOM Project - System Analysis, Design, and Configuration ... Gregory Reed John P... more SDG&E Talega STATCOM Project - System Analysis, Design, and Configuration ... Gregory Reed John Paserba Terry Croasdaile Rob Westover ... Shinji Jochi Naoki Morishima Masatoshi Takeda Takashi Sugiyama Yoshihiro Hamasaki ... Mitsuhishi Electric Power Products, ...
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The diploid frog Xenopus tropicalis is becoming a powerful developmental genetic model system. Se... more The diploid frog Xenopus tropicalis is becoming a powerful developmental genetic model system. Sequencing of the X. tropicalis genome is nearing completion and several labs are embarking on mutagenesis screens. We are interested in developing insertional mutagenesis strategies in X. tropicalis. Transposon-mediated insertional mutagenesis, once used exclusively in plants and invertebrate systems, is now more widely applicable to vertebrates. The first step in developing transposons as tools for mutagenesis is to demonstrate that these mobile elements function efficiently in the target organism. Here, we show that the Medaka fish transposon, Tol2, is able to stably integrate into the X. tropicalis genome and will serve as a powerful tool for insertional mutagenesis strategies in the frog.
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Power Systems, …, 1993
- A static var generator (SVG) using self -commutated inverters of 8OMVA capacity was developed a... more - A static var generator (SVG) using self -commutated inverters of 8OMVA capacity was developed and successfully applied to an actual 154KV power system to stabilize the power system. The SVG consists of 48-pulse multiple inverters whereby GTO thyristors are ...
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Psychiatry and …, 1997
To characterize the cytoskeletal aberration due to traumatic injury, temporal and regional profil... more To characterize the cytoskeletal aberration due to traumatic injury, temporal and regional profiles of changes in immunoreactivity of microtubule-associated protein 2 (MAP2), neurofilament heavy subunit protein (NFH) and heat shock protein 72 (HSP72) were investigated after different ...
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Psychiatry Research: …, 2000
Psychogenic amnesia is characterized by an inability to recall information already stored in the ... more Psychogenic amnesia is characterized by an inability to recall information already stored in the patient's memory. It is usually related to a stressful or traumatic event that cannot be explained by manifest brain damage. To examine the underlying functional disturbance of brain ...
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Dementia and Geriatric Cognitive Disorders, 2006
Cognitive impairment in patients with idiopathic normal pressure hydrocephalous (iNPH) has not be... more Cognitive impairment in patients with idiopathic normal pressure hydrocephalous (iNPH) has not been clearly documented. We performed standardized neuropsychological assessments of 21 patients with iNPH and of 42 patients with Alzheimer’s disease (AD) matched to the patients with iNPH 2:1 by age, sex, and Mini-Mental State Examination score. Compared with the AD group, the iNPH group scored significantly higher on
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Dementia and Geriatric Cognitive Disorders, 2005
We compared the scores of the Frontal Assessment Battery (FAB), initial fluency subtest, category... more We compared the scores of the Frontal Assessment Battery (FAB), initial fluency subtest, category fluency subtest and subtests of the Mini-Mental State Examination (MMSE) between patients with idiopathic normal pressure hydrocephalus (iNPH) and age-, sex- and MMSE-matched patients with Alzheimer’s disease (AD). In patients with iNPH, the time and number of steps required to go and come back a 10-meter
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Alzheimers & Dementia, 2009
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Psychogeriatrics, 2009
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Papers by Masatoshi Takeda