Papers by Yasser El-Wazir
Medical teacher, Jun 3, 2024
Deleted Journal, Mar 1, 2024
COVID-19, pandemic, had led to an unprecedented challenge to medical schools worldwide. Being not... more COVID-19, pandemic, had led to an unprecedented challenge to medical schools worldwide. Being not an exception, the Faculty of Medicine -Suez Canal University (FOMSCU) faced quite a challenging situation that could have almost stopped teaching and learning.. This report was prepared to describe the actions taken by FOMSCU during this period to maintain teaching and learning including students and faculty feedback. An integrated system of distance online learning was established, and offline alternatives were taken for students with poor internet connectivity Feedback of staff and students was collected from the end of July 2020 to the end of August 2020 using a specially designed questionnaire for this purpose. Students and faculty found asynchronous online teaching was as good as face to face however, they have some negative comments on synchronous sessions. The overall experience was rated as useful by both faculty & students and should be maintained thereafter.
BMC Medical Education
Medical educators are in a continuous quest to close the gap between the needs of medical practic... more Medical educators are in a continuous quest to close the gap between the needs of medical practice and the rising expectations of the communities in their countries. During the past two decades, competency-based medical education has been evolving as an appealing strategy to close this gap. In 2017, the Egyptian medical education authorities mandated all medical schools to change their curricula to comply with revised national academic reference standards, which changed from outcome-based to competency-based. In parallel, they also changed the timeline of all medical programs for six years of studentship and one-year internship to five years and two years, respectively. This substantial reform involved the assessment of the existing situation, an awareness campaign for the proposed changes and an extensive national faculty development program. Monitoring the implementation of this substantial reform was performed through surveys, field visits and meetings with students, teaching sta...
Suez Canal Uni Med …, 1999
Page 1. Suez Canal Univ Med J Vol. 2 No. 1, March, 1999 61-72 Physiological Assessment of Cardiac... more Page 1. Suez Canal Univ Med J Vol. 2 No. 1, March, 1999 61-72 Physiological Assessment of Cardiac Autonomic Reflexes in Diabetics SamyM. Makary, Hamdy A. Selim1, Yasser M. El-Wazir, Abd El-Aziz Mahmoud Departments ...
Andrology, 2019
Background: The possible role of phosphodiesterase 5 inhibitors (PDE5Is) in prevention of negativ... more Background: The possible role of phosphodiesterase 5 inhibitors (PDE5Is) in prevention of negative effect of diabetes mellitus (DM) on erectile function is not well settled. Objectives: To investigate the effect of early administration of vardenafil on erectile function, cavernosal structure, and genes expression in a rat model of DM. Materials and methods: This experimental study was carried out at Suez Canal University's research laboratory. This study was conducted on a total of 60 adult male Albino Wistar rats, aged 60-80 days and weighing an average of 200 g. Rats were equally divided into six groups of 10 rats each: Group I (sham); Group II (DM with no treatment); Groups III, IV, V, and VI received vardenafil started at day 1, week 4, week 8, and week 12 after induction of DM, respectively. Functional study assessment of all groups was performed before euthanization, and then tissues were harvested for histopathological, ultrastructural, and molecular examinations. Results: There was a significant difference of intracavernosal pressure between early (94 AE 2.18) and late (40.5 AE 1.94) treatment groups (p = 0.011). Histopathological and ultrastructural changes of DM with no treatment and late treatment groups showed distorted cavernous architecture and extensive fibrosis. There was significant difference of smooth muscle to collagen ratio between early and late treatment groups (p = 0.035). There was significant upregulation of nNOS(p = 0.021) and iNOS (p = 0.047) in early vs. late treatment group. The difference was insignificant in eNOS (p = 0.386) or TGF-b1(p = 0.149). Discussion and conclusion: Early treated rats with vardenafil had preserved erection and normal cavernosal structure, ultrastructure and gene expression of iNOS, nNOS, eNOS, and TGF-b1. Quantification of gene expression would improve our knowledge regarding cytokines expression and molecular background of DM-associated ED. Clinical application of this result may encourage early administration of PDE5I to prevent deleterious effects of DM on erectile function in newly diagnosed DM patients with probable uncontrolled blood glucose.
Original paper, 2019
bstract:
Stress is known to increase the activity of the hypothalamic adrenal axis.
Some researc... more bstract:
Stress is known to increase the activity of the hypothalamic adrenal axis.
Some researchers were unable to find an effect of stress on memory retrieval
in females. A quantitative electroencephalogram (qEEG) provides an objective
assessment of the electrical activity of the brain via many techniques such as
power spectral analysis and coherence. The current study was conducted to
assess the effect of examination stress on qEEG oscillations during delayed
memory retrieval in females during the luteal phase. A Prospective
longitudinal study was applied to 11 healthy females. qEEG analysis was done
using the relative power (RP) and the peak power frequency (PPF) during
memory tasks. Serum cortisol was analyzed as a measure of stress. Serum
estrogen and progesterone were assessed to validate the phase of the
menstrual cycle. All hormonal analyses were done by enzyme-linked
immunosorbent assay (ELISA) technique. The results revealed insignificant
effects on the quantitative analysis of EEG oscillations during the luteal phase
regarding the mean relative power in all frequency bands (delta "δ"; P-value:
0.38 and 0.41, theta "Ɵ"; P-value: 0.26 and 0.87, alpha "α"; P-value: 0.69 and
0.85 and beta "β"; P-value: 0.91 and 0.74 during the word and photo
recognition tasks; respectively). Regarding the peak power frequency EEG
analysis; there were no significant differences in (δ, Ɵ, α, and β) EEG bands
during the word and photo- recognition tasks over the central (C3 and C4) and
occipital (O1 and O2) sites in stress compared to non-stress periods; P-
values were: C3: 0.37 and 0.55, C4: 0.33 and 0.11, and were: O1: 0.13 and
0.13 and O2: 0.9 and 0.29 during the word and photo recognition memory
tasks; respectively. It is concluded that gonadal steroids have no effect on
brain oscillation during both resting and stress conditions.
Keywords: qEEG, Peak power frequency, Spectral analysis, Stress, Memory,
Health Professions Education, 2016
Mechanistic insights into aging, cell-cycle progression, and
Background : Heart failure is a significant burden to health care systems in the world. One of it... more Background : Heart failure is a significant burden to health care systems in the world. One of its major causes is myocardial infarction (MI). Recent developments in stem cells may offer ways to manage heart failure by replacing damaged cardiac muscle with healthy tissue. This study aimed at examining the regenerative effect of intravenously transplanted human umbilical cord blood CD34+ stem cell in a rat model of acute MI. Methods : Forty adult female rats were equally randomized into 5 groups. Groups I and II received saline alone or saline followed by isolation buffer respectively to serve as control groups. The other 3 groups were subjected to induction of acute MI using subcutaneous injection of isoprenaline hydrochloride. In groups III and IV, animals were sacrificed after one week and four weeks respectively. One week after induction of MI, animals in group V received intravenous injection of 4 x 10 6 CD34+ stem cells separated from the human umbilical cord blood of male fetu...
Stress is known to increase the activity of the hypothalamic adrenal axis. Some researchers were ... more Stress is known to increase the activity of the hypothalamic adrenal axis. Some researchers were unable to find an effect of stress on memory retrieval in females. A quantitative electroencephalogram (qEEG) provides an objective assessment of the electrical activity of the brain via many techniques such as power spectral analysis and coherence. The current study was conducted to assess the effect of examination stress on qEEG oscillations during delayed memory retrieval in females during the luteal phase. A Prospective longitudinal study was applied to 11 healthy females. qEEG analysis was done using the relative power (RP) and the peak power frequency (PPF) during memory tasks. Serum cortisol was analyzed as a measure of stress. Serum estrogen and progesterone were assessed to validate the phase of the menstrual cycle. All hormonal analyses were done by enzyme-linked immunosorbent assay (ELISA) technique. The results revealed insignificant effects on the quantitative analysis of EE...
Acute renal failure (ARF) is a common clinical problem with increasing incidence, serious consequ... more Acute renal failure (ARF) is a common clinical problem with increasing incidence, serious consequences, unsatisfactory therapeutic options and enormous financial burden to society. The aim is to investigate the role of human umbilical cord blood (HUCB) derived mesenchymal (MSCs) and CD34 + hematopoietic stem cell therapy in repair of renal damage and improvement of renal function in cisplatin-induced ARF model. Forty four rats were divided into 4 equal groups. ARF was induced in 3 groups using cisplatin and was confirmed by an increase in serum urea and creatinine levels after 5 days. On the same day, 2 groups were injected via the tail vein by either MSCs (1x10 6 cells/rat) or CD34 + hematopoietic cells (5 x10 5 cells/rat). The third group received intravenous injection of phosphate buffer saline and served as positive control, while the last group was normal control. Renal functions were followed up every 4 days. Thirty-three days after initiation of cisplantin injection, rats wer...
End-stage liver disease is a worldwide cause of morbidity and mortality, which is associated with... more End-stage liver disease is a worldwide cause of morbidity and mortality, which is associated with a considerable economic burden. As the disease progresses, fibrosis will replace the hepatic architecture and compromise liver functions. The regenerative approach for the injured liver can provide a hope for these patients; however, it is still facing many challenges. In the current study, we aimed at (1) assessing hepatic regenerative capacity of mesenchymal stem cells, isolated from human umbilical cord blood (HMSCs), in a rat model of carbon-tetrachloride (CCL4) induced liver fibrosis, (2) comparing the therapeutic effects with other cell populations derived from umbilical cord blood and (3) evaluating the host response to the human-derived cells. Fifteen rats received either the whole mononuclear cell fraction (HMNCs), CD34-ve subpopulation or HMSCs. A fourth group did not receive any treatment and another group was left without induction of fibrosis as positive and negative contro...
Aim of the Work: Our study aimed at investigation of the capacity of allogenic bone marrow derive... more Aim of the Work: Our study aimed at investigation of the capacity of allogenic bone marrow derived Mesenchymal Stem Cells (MSCs) versus Mononuclear Stem Cells (MNSCs) to regenerate liver in carbon tetrachloride (CCl4) animal model of liver fibrosis. The role of regulatory T cells (CD4+ & IL2α/CD25+) in controlling homing of the transplanted stem cells was also evaluated. Animal: After induction of liver fibrosis for 8 weeks, the survived female rats were divided into positive control group (CO+) and two groups treated with MSCs and MNSCs isolated from Sprague Dawley male rats. To provide independent evidence of homing of transplanted male donor cells, real time PCR was done to detect sex determining region on the Y chromosome (Sry) gene. N-terminal Procollagen III (PIIINP), liver function test (alanine aminotransferase ALT, aspartate aminotransferase AST, Gamma Glutamyl Transferase GGT and Albumin Alb) were assessed. Histopatological examination of livers was done to evaluate the re...
Among the various health problems associated with obesity, cardiac autonomic neuropathy is one of... more Among the various health problems associated with obesity, cardiac autonomic neuropathy is one of the serious and relatively under-investigated problems. The authors have previously showed, in 2008, that vagal dysfunction is the main underlying factor in cardiac autonomic neuropathy in a rat model of congenital obesity. The aim of this article is to review the published findings in this topic since then and to compare the data in rats with those in human subjects. Keywords: Autonomic regulation, obesity, obese rats, obese humans cardiovascular
The Asia Pacific Scholar
Introduction: Although, several factors have been identified as significant determinants in onlin... more Introduction: Although, several factors have been identified as significant determinants in online learning, the human interactions with those factors and their effect on academic achievement are not fully elucidated. This study aims to determine the effect of self-regulated learning (SRL) on achievement in online learning through exploring the relations and interaction of the conception of learning, online discussion, and the e-learning experience. Methods: A non-probability convenience sample of 128 learners in the Health Professions Education program through online learning filled-out three self-reported questionnaires to assess SRL strategies, the conception of learning, the quality of e-Learning experience and online discussion. A scoring rubric was used to assess the online discussion contributions. A path analysis model was developed to examine the effect of self-regulated learning on achievement in online learning through exploring the relations and interaction among the oth...
Advanced Education
Purpose: Cognitive load theory (CLT) is receiving increased recognition in medical education and ... more Purpose: Cognitive load theory (CLT) is receiving increased recognition in medical education and it was cited as an important theoretical framework for simulation-based medical education. Simulated learning environments can place a high demand on the cognitive resources of the learners, hence, we aimed to design an instructional framework to optimise the total cognitive load imposed on the medical students during their clinical skills training in the clinical skills laboratory. Method: This study is a quasi-experimental post-test design. The sampling technique was purposive sampling, which included year 2 students at the Faculty of Medicine-Suez Canal University population. The study was conducted in the clinical skills and simulation laboratory. The intervention group received a developed instructional design framework based on CLT. The control group learned with the ordinary teaching method without any intervention. The cognitive load was measured using the Cognitive Load Inventor...
Suez Canal University Medical Journal
Port Said Scientific Journal of Nursing
Background: Curriculum development for nursing in Health Technical Institute (HTI) becomes a need... more Background: Curriculum development for nursing in Health Technical Institute (HTI) becomes a needed issue as a second level of nursing education in Egypt in a scarce nursing labor market. The aim: of this study was to evaluate staff teaching general nursing branch. research Design was comparative study design was utilize in this study Settings the study was carried out in Health Technical in Port Said Sample a Purposive sample was followed in the present study. The study subjects consisted of 76 stakeholders, whom are students (undergraduate and graduates of HTI), internal and external educators. The tool that was used for data collection was staff teaching Evaluation Questionnaire. Results: The study results indicated that teaching staff often caring about students successful scored the highest percentage; whereas rarely there is committee to evaluate teaching staff periodically. Conclusion: It was concluded that no committee to evaluate teaching staff of general nursing branch at Health Technical Institute periodically. Recommendations: It was recommended that teaching staff should be revise for participating them in planning and revising courses, improve their knowledge practice and evaluating them by committee periodically are recommended for target development
Suez Canal University Medical Journal
Background: Researches revealed that increased levels of stress hormones lead to enhancement of m... more Background: Researches revealed that increased levels of stress hormones lead to enhancement of memory consolidation in rodents. Recently, it became apparent that the brain oscillations reflect cognitive aspects and information processing in the brain. Quantitative electroencephalogram (qEEG) provides an objective assessment of the electrical activity of the brain via many techniques such as power spectral analysis and coherence. Aim: To assess the effect of gender on the qEEG oscillations during the delayed memory retrieval after exposure to acute stress. Subjects and Methods: This prospective (longitudinal) study was applied on 34 healthy undergraduate medical students from both genders (17 males and 17 females) in the Faculty of Medicine, Suez Canal University. The qEEG analysis was done in neurology department, Suez Canal University Hospital using the relative power (RP) during memory tasks. Serum cortisol was analyzed by enzyme linked immunosorbent assay (ELISA) as a measure for stress. Results: The results revealed insignificant effect of gender on the quantitative analysis of EEG oscillations regarding the mean relative power in all frequency bands (delta "δ": 2.36±0.72; 2.04±0.46, theta "Ɵ": 13.72±3.13; 12.72±3.58, alpha "α": 12.72±3.58; 18.50±3.81 and beta "β": 33.26±3.23; 32.72±4.47 for males and females respectively during the examination period). Whereas, there was a positive correlation between the serum cortisol level and the mean relative power of delta (r: 0.53, p=0.03), and theta (r: 0.55, p=0.02) and a negative correlation with beta (r:-0.51, p= 0.04) bands in males only. Conclusion: There are positive correlations for delta and theta bands and negative correlation for beta band between the quantitative electroencephalographic analysis (RP) with the hormonal measure of the stress in spite of the insignificant changes in the EEG oscillations in the non-stress and stress periods.
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Papers by Yasser El-Wazir
Stress is known to increase the activity of the hypothalamic adrenal axis.
Some researchers were unable to find an effect of stress on memory retrieval
in females. A quantitative electroencephalogram (qEEG) provides an objective
assessment of the electrical activity of the brain via many techniques such as
power spectral analysis and coherence. The current study was conducted to
assess the effect of examination stress on qEEG oscillations during delayed
memory retrieval in females during the luteal phase. A Prospective
longitudinal study was applied to 11 healthy females. qEEG analysis was done
using the relative power (RP) and the peak power frequency (PPF) during
memory tasks. Serum cortisol was analyzed as a measure of stress. Serum
estrogen and progesterone were assessed to validate the phase of the
menstrual cycle. All hormonal analyses were done by enzyme-linked
immunosorbent assay (ELISA) technique. The results revealed insignificant
effects on the quantitative analysis of EEG oscillations during the luteal phase
regarding the mean relative power in all frequency bands (delta "δ"; P-value:
0.38 and 0.41, theta "Ɵ"; P-value: 0.26 and 0.87, alpha "α"; P-value: 0.69 and
0.85 and beta "β"; P-value: 0.91 and 0.74 during the word and photo
recognition tasks; respectively). Regarding the peak power frequency EEG
analysis; there were no significant differences in (δ, Ɵ, α, and β) EEG bands
during the word and photo- recognition tasks over the central (C3 and C4) and
occipital (O1 and O2) sites in stress compared to non-stress periods; P-
values were: C3: 0.37 and 0.55, C4: 0.33 and 0.11, and were: O1: 0.13 and
0.13 and O2: 0.9 and 0.29 during the word and photo recognition memory
tasks; respectively. It is concluded that gonadal steroids have no effect on
brain oscillation during both resting and stress conditions.
Keywords: qEEG, Peak power frequency, Spectral analysis, Stress, Memory,
Stress is known to increase the activity of the hypothalamic adrenal axis.
Some researchers were unable to find an effect of stress on memory retrieval
in females. A quantitative electroencephalogram (qEEG) provides an objective
assessment of the electrical activity of the brain via many techniques such as
power spectral analysis and coherence. The current study was conducted to
assess the effect of examination stress on qEEG oscillations during delayed
memory retrieval in females during the luteal phase. A Prospective
longitudinal study was applied to 11 healthy females. qEEG analysis was done
using the relative power (RP) and the peak power frequency (PPF) during
memory tasks. Serum cortisol was analyzed as a measure of stress. Serum
estrogen and progesterone were assessed to validate the phase of the
menstrual cycle. All hormonal analyses were done by enzyme-linked
immunosorbent assay (ELISA) technique. The results revealed insignificant
effects on the quantitative analysis of EEG oscillations during the luteal phase
regarding the mean relative power in all frequency bands (delta "δ"; P-value:
0.38 and 0.41, theta "Ɵ"; P-value: 0.26 and 0.87, alpha "α"; P-value: 0.69 and
0.85 and beta "β"; P-value: 0.91 and 0.74 during the word and photo
recognition tasks; respectively). Regarding the peak power frequency EEG
analysis; there were no significant differences in (δ, Ɵ, α, and β) EEG bands
during the word and photo- recognition tasks over the central (C3 and C4) and
occipital (O1 and O2) sites in stress compared to non-stress periods; P-
values were: C3: 0.37 and 0.55, C4: 0.33 and 0.11, and were: O1: 0.13 and
0.13 and O2: 0.9 and 0.29 during the word and photo recognition memory
tasks; respectively. It is concluded that gonadal steroids have no effect on
brain oscillation during both resting and stress conditions.
Keywords: qEEG, Peak power frequency, Spectral analysis, Stress, Memory,