SGT College of Pharmacy

Since history, medicinal plants and their derived products have been playing an immense role in the alleviation of several diseases due to their multi-mechanistic and therapeutic action exhibited by various phytochemicals present in the plants. Based on the facts, the present study is associated to explore the multi-mechanistic and therapeutic action of Boerhavia diffusa L. (B. diffusa) based on its metabolites. In this study, network pharmacology analysis was performed to determine the interaction of B. diffusa metabolites against several genes involved in the pathophysiology of kidney disease and associated complications. Gene ontology analysis was performed to determine several pathophysiological pathways in the alleviation of kidney disease. Furthermore, in silico analysis was performed between quercetin and the most prominent genes screened from network pharmacology analysis. The results showed that B. diffusa alleviates acute or chronic kidney dysfunction via regulation of several pathophysiological pathways such as oxidative stress, inflammatory stress, glomerulonephritis, polycystic kidney syndrome, hypertension, diabetic retinopathy, positive regulation of cell death, etc. In silico analysis showed that quercetin exhibited prominent interaction with CAT, PPARA and TNF-a genes in form of conventional hydrogen bonding. Hence, it can be concluded that B. diffusa exhibitsa multi-mechanistic approach to alleviating kidney dysfunction and can be a promising agent for the management of kidney disease.