2-Metil-2-butanol

2-Metil-2-butanol
Ball-and-stick model of 2-methyl-2-butanol	Space-filling model of the 2-methyl-2-butanol
	Preferentno IUPAC ime 2-Metil-2-butanol
Naziv po klasifikaciji	2-Metilbutan-2-ol
Drugi nazivi	terc-Amil alkohol; Amylene hydrate; Dimethylethylcarbinol; tert-pentil alkohol
Identifikacija
CAS registarski broj	75-85-4
PubChem	6405
ChemSpider	6165
UNII	69C393R11Z
EINECS broj	200-908-9
UN broj	1105
KEGG	D02931
MeSH	tert-amyl+alcohol
ChEMBL	CHEMBL44658
RTECS registarski broj toksičnosti	SC0175000
Bajlštajn	1361351
Jmol-3D slike	Slika 1
SMILES
	CCC(C)(C)O
InChI
	InChI=1S/C5H12O/c1-4-5(2,3)6/h6H,4H2,1-3H3 ; Kod: MSXVEPNJUHWQHW-UHFFFAOYSA-N
Svojstva
Molekulska formula	C5H12O
Molarna masa	88.15 g mol−1
Agregatno stanje	Bezbojna tečnost
Miris	miris kamfora, peperminta
Gustina	805 mg cm−3
Tačka topljenja	-9 °C, 264 K, 16 °F
Tačka ključanja	101-103 °C, 374-376 K, 214-217 °F
Rastvorljivost u vodi	120 g dm−3
log P	1,095
Napon pare	1,6 kPa (na 20 °C)
Indeks prelamanja (nD)	1,405
Termohemija
Standardna entalpija stvaranja jedinjenja ΔfHo298	−380,0–−379,0 kJ mol−1
Std entalpija; sagorevanja ΔcHo298	−3,3036–−3.3026 MJ mol−1
Standardna molarna entropija So298	229,3 J K−1 mol−1
Opasnost
Podaci o bezbednosti prilikom rukovanja (MSDS)	hazard.com
EU-klasifikacija	F Xn
EU-indeks	603-007-00-2
NFPA 704	3 1 0
R-oznake	R11, R20, R37/38
S-oznake	S2, S46
Tačka paljenja	19 °C
Tačka spontanog paljenja	437 °C
Eksplozivni limiti	9%
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

2-Metil-2-butanol (terc-amil alkohol, 2M2B, amilen hidrat) je jedan od izomera amil alkohola. On je čista, bezbojna tečnost sa jakim mirisom peperminta ili kamfora.^[7]^[8] Kod ljudi on ispoljava sedativno, hipnotičko, i antikonvulsivno dejstvo slično etanolu pri gutanju ili udisanju. Ranije je korišten u medicini za te svrhe.^[9] On je aktivan u dozama u opsegu od 2.000-4.000 mg, te je 20 puta potentniji od etanol.a^[10]^[11] Njegov hipnotički potencijal je između hloral hidrata i paraldehida.^[12] In humans, 2-methyl-2-butanol is metabolized primarily via gluconoridation and oxidation to 2,3-dihydroxy-2-methylbutane.^[13] Prekomerna doza proizvodi simptome slične alkoholnom trovanju.

Reference

↑ ^1,0 ^1,1 ^1,2 ^1,3 ^1,4 ^1,5 „tert-amyl alcohol - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005.. Identification and Related Records. Pristupljeno 13. 12. 2011.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd izd.). Philadelphia: P. Blakiston's Son & Co. str. 18.
↑ H. C. Wood & R. M. Smith, ur. (1887-09-15). „Amylene hydrate - a new hypnotic”. Therapeutic Gazette - A monthly journal of physiological and clinical therapeutics (Detroit MI and Philadelpia PA: G. S. Davis) 3: 605–606.
↑ Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. str. 45. ISBN 1-56670-223-2.
↑ Hans Brandenberger & Robert A. A. Maes, ur. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. str. 401. ISBN 3-11-010731-7.
↑ D. W. Yandell et al. (1888). „Amylene hydrate, a new hypnotic”. The American Practitioner and News (Lousville KY: John P. Morton & Co) 5: 88–89.
↑ F. A. Castle & C. Rice (March 1888). „Amylene and amylene hydrate”. The American Druggist 17 (3): 58–59.
↑ Collins, A. S.; Sumner, S. C.; Borghoff, S. J.; Medinsky, M. A. (1999). „A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures”. Toxicological sciences : an official journal of the Society of Toxicology 49 (1): 15–28. DOI:10.1093/toxsci/49.1.15. PMID 10367338.

Literatura

Hans Brandenberger & Robert A. A. Maes, ur. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. str. 401. ISBN 3-11-010731-7.
Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd izd.). Philadelphia: P. Blakiston's Son & Co. str. 18.
Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. str. 45. ISBN 1-56670-223-2.

Povezano

[PubChem-1] 1,0 ^1,1 ^1,2 ^1,3 ^1,4 ^1,5 „tert-amyl alcohol - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005.. Identification and Related Records. Pristupljeno 13. 12. 2011.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[6] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[7] Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd izd.). Philadelphia: P. Blakiston's Son & Co. str. 18.

[8] H. C. Wood & R. M. Smith, ur. (1887-09-15). „Amylene hydrate - a new hypnotic”. Therapeutic Gazette - A monthly journal of physiological and clinical therapeutics (Detroit MI and Philadelpia PA: G. S. Davis) 3: 605–606.

[9] Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. str. 45. ISBN 1-56670-223-2.

[10] Hans Brandenberger & Robert A. A. Maes, ur. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. str. 401. ISBN 3-11-010731-7.

[11] D. W. Yandell et al. (1888). „Amylene hydrate, a new hypnotic”. The American Practitioner and News (Lousville KY: John P. Morton & Co) 5: 88–89.

[12] F. A. Castle & C. Rice (March 1888). „Amylene and amylene hydrate”. The American Druggist 17 (3): 58–59.

[13] Collins, A. S.; Sumner, S. C.; Borghoff, S. J.; Medinsky, M. A. (1999). „A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures”. Toxicological sciences : an official journal of the Society of Toxicology 49 (1): 15–28. DOI:10.1093/toxsci/49.1.15. PMID 10367338.

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