Izvorni kod stranice GM1 (gangliozid)

{{chembox-lat
| verifiedrevid = 421946867
| ImageFile = GM1 ganglioside.png
| ImageSize = 250px
| IUPACName = (2''S'',4''S'',5''R'',6''R'')-5-acetamido-2-[(2''S'',3''R'',4''R'',5''S'',6''R'')-5-[(2''S'',3''R'',4''R'',5''R'',6''R'')-3-acetamido-5-hidroksi-6-(hidroksimetil)-4-[(2''R'',3''R'',4''S'',5''R'',6''R'')-3,4,5-trihidroksi-6-(hidroksimetil)oksan-2-il]oksioksan-2-il]oksi-2-[(2''R'',3''S'',4''R'',5''R'',6''R'')-4,5-dihidroksi-6-[(''E'',2''R'',3''S'')-3-hidroksi-2-(ikozanoilamino)icos-4-enoksi]-2-(hidroksimetil)oksan-3-il]oksi-3-hidroksi-6-(hidroksimetil)oksan-4-il]oksi-4-hidroksi-6-[(1''R'',2''R'')-1,2,3-trihidroksipropil]oksan-2-karboksilna kiselina
| IUPACName_hidden = yes
| OtherNames = Monozialotetraheksozilgangliozid
| Section1 = {{Chembox Identifiers-lat
|   ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4593688
| InChI = 1/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(87)76-44(45(84)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)41-98-69-61(94)59(92)63(50(39-80)101-69)103-71-62(95)67(107-73(72(96)97)35-46(85)53(74-42(3)82)66(106-73)55(88)47(86)36-77)64(51(40-81)102-71)104-68-54(75-43(4)83)65(57(90)49(38-79)99-68)105-70-60(93)58(91)56(89)48(37-78)100-70/h31,33,44-51,53-71,77-81,84-86,88-95H,5-30,32,34-41H2,1-4H3,(H,74,82)(H,75,83)(H,76,87)(H,96,97)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66-,67+,68-,69+,70-,71-,73-/m0/s1
| InChIKey = QPJBWNIQKHGLAU-BVLUPYCXBP
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(87)76-44(45(84)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)41-98-69-61(94)59(92)63(50(39-80)101-69)103-71-62(95)67(107-73(72(96)97)35-46(85)53(74-42(3)82)66(106-73)55(88)47(86)36-77)64(51(40-81)102-71)104-68-54(75-43(4)83)65(57(90)49(38-79)99-68)105-70-60(93)58(91)56(89)48(37-78)100-70/h31,33,44-51,53-71,77-81,84-86,88-95H,5-30,32,34-41H2,1-4H3,(H,74,82)(H,75,83)(H,76,87)(H,96,97)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66-,67+,68-,69+,70-,71-,73-/m0/s1
|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
|  Beilstein = 
|  Gmelin = 
|  3DMet = 
| StdInChIKey = QPJBWNIQKHGLAU-BVLUPYCXSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 37758-47-7
|   PubChem = 5497107
|   SMILES = O[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@@]5(C(O)=O)O[C@@]([H])([C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C5)[C@H]2O)[C@@H](CO)O[C@@H](OC[C@@H]([C@@H](O)/C=C/CCCCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCCCC)=O)[C@@H]1O
|   MeSHName = G(M1)+Ganglioside
  }}
| Section2 = {{Chembox Properties-lat
|  Formula = 
|   C=77|H=139|N=3|O=31
|   Appearance = 
|   Density = 
|   MeltingPt = 
|   BoilingPt = 
  }}
| Section3 = {{Chembox Hazards-lat
|   Solubility = 
|   MainHazards = 
|   FlashPt = 
|   Autoignition = 
  }}
}}

'''GM1''' (monozialotetraheksozilgangliozid) je prototipni [[gangliozid]]. On je član ganglio serije gangliozida koja sadrži jedan ostatak [[sijalinska kiselina|sijalinske kiseline]]. GM1 ima važna [[fiziologija|fiziološka]] svojstava i utiče na [[Neuroplastičnost|neuronsku plastičnost]] i mehanizam popravke, kao i na otpuštanje [[neurotrofin]]a u [[mozak|mozgu]]. Osim njegove funkcije u moždanoj fiziologiji, GM1 je mesto vezivanja [[Toksin kolere|kolerinog toksina]] i [[Enterotoksigena Ešerihija koli|E. coli]] [[toplotno nestabilni enterotoksin|toplotno nestabilnog enterotoksina]] (uzročnika [[Dijareja putnika|dijareje putnika]]).<ref name="pmid16158191">{{cite journal | author = Mocchetti I | title = Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins | journal = Cell. Mol. Life Sci. | volume = 62 | issue = 19–20 | pages = 2283–94 | year = 2005 | pmid = 16158191 | doi = 10.1007/s00018-005-5188-y}}</ref><ref>{{cite journal |author=Chen JC, Chang YS, Wu SL, ''et al.'' |title=Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa |journal=J Ethnopharmacol |volume=113 |issue=2 |pages=233–9 |year=2007 |month=September |pmid=17624704 |doi=10.1016/j.jep.2007.05.031 }}</ref>

[[Anti-gangliozidna antitela|Antitela za GM1]] su prisutna u povišenoj koncentraciji kod obolelih od [[Gijen-Bareov sindrom|Gijen-Bareovog sindroma]], [[demencija|demencije]] i [[lupus]]a, mada njihova funkcija nije jasna.<ref name="pmid8027366">{{cite journal | author = Bansal AS, Abdul-Karim B, Malik RA, ''et al.'' | title = IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls | url = https://archive.org/details/sim_journal-of-clinical-pathology_1994-04_47_4/page/300 | journal = J. Clin. Pathol. | volume = 47 | issue = 4 | pages = 300–2 | year = 1994 | pmid = 8027366 | doi =10.1136/jcp.47.4.300 | pmc = 501930 }}</ref> Postoji evidencija koja sugeriše da su ta antitela povezana sa [[dijareja|dijarejom]] kod Gijen-Bareovog sindroma.<ref name="pmid9313102">{{cite journal | author = Irie S, Saito T, Kanazawa N, ''et al.'' | title = Relationships between anti-ganglioside antibodies and clinical characteristics of Guillain-Barré syndrome | journal = Intern. Med. | volume = 36 | issue = 9 | pages = 607–12 | year = 1997 | pmid = 9313102 | doi =10.2169/internalmedicine.36.607 }}</ref>

== Dodatne slike ==
<gallery>
 Image:Sphingolipidoses.svg|Sfingolipidoze
 Image:Structure of GM1, GM2, GM3.png|Strukture GM1, GM2, GM3 [[gangliozid]]a
</gallery>

== Reference ==
{{reflist|2}}

== Spoljašnje veze ==
{{Portal-lat|Hemija}}

{{Sfingolipidi-lat}}

[[Kategorija:Glikolipidi]]