Izvorni kod stranice Supstanca P

{{Infobox protein-lat
| Name = Tahikinin, prekurzor 1
| caption = Model supstance P
| image = Substance_P.png
| width = 180
| HGNCid = 11517
| Symbol = TAC1
| AltSymbols = TAC2, NKNA
| EntrezGene = 6863
| OMIM = 162320
| RefSeq = NM_003182
| UniProt = P20366
| PDB = 
| ECnumber = 
| Chromosome = 7
| Arm = q
| Band = 21
| LocusSupplementaryData = -q22
}}
{{chembox-lat
| verifiedrevid = 414512791
|ImageFile=Substance P.svg
|ImageSize=275px
|IUPACName=
|OtherNames=
|Section1= {{Chembox Identifiers-lat
|  Abbreviations = 
|  ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 33558
| InChI = 1/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
| InChIKey = ADNPLDHMAVUMIW-CUZNLEPHBU
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 235363
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
|  Beilstein = 
|  Gmelin = 
|  3DMet = 
| StdInChIKey = ADNPLDHMAVUMIW-CUZNLEPHSA-N
| CASNo=33507-63-0
|  PubChem=36511 
|  SMILES=
|  MeSHName=Substance+P
  }}
|Section2= {{Chembox Properties-lat
|  Formula = 
|  Formula=C<sub>63</sub>H<sub>98</sub>N<sub>18</sub>O<sub>13</sub>S
|  MolarMass=1347.63 g/mol
|  Appearance=
|  Density=
|  MeltingPt=
|  BoilingPt=
|  Solubility=
  }}
|Section3= {{Chembox Hazards-lat
|  MainHazards=
|  FlashPt=
|  Autoignition=
  }}
}}
U [[neuronauka|neuronauci]] '''supstanca P''' (SP) je [[neuropeptid]]: undekapeptid koji funkcioniše kao [[neurotransmiter]] i [[neuromodulator]].<ref name="pmid11378438">{{cite journal | author = Harrison S, Geppetti P | title = Substance p | journal = The International Journal of Biochemistry & Cell Biology | volume = 33 | issue = 6 | pages = 555–76 | year = 2001 | month = June | pmid = 11378438 | doi = 10.1016/S1357-2725(01)00031-0  | url =https://archive.org/details/sim_international-journal-of-biochemistry-cell-biology_2001-06_33_6/page/555}}</ref><ref name="pmid14754378">{{cite journal | author = Datar P, Srivastava S, Coutinho E, Govil G | title = Substance P: structure, function, and therapeutics | journal = Current topics in medicinal chemistry | volume = 4 | issue = 1 | pages = 75–103 | year = 2004 | pmid = 14754378 | doi = 10.2174/1568026043451636 | url = http://www.bentham-direct.org/pages/content.php?CTMC/2004/00000004/00000001/0009R.SGM | access-date = 2021-08-12 | archive-date = 2009-08-17 | archive-url = https://web.archive.org/web/20090817115536/http://www.bentham-direct.org/pages/content.php?CTMC%2F2004%2F00000004%2F00000001%2F0009R.SGM | dead-url = yes }}</ref> Ovaj molekul pripada familiji [[tahikinin]]skih neuropeptida. Supstanca P i njen blisko srodni neuropeptid [[neurokinin A]] (NKA) nastaju iz poliproteinskog prekurzora nakon diferencijalnog splajsovanja gena preprotahikinina A. Aminokiselinska sekvenca supstance P je<ref name="pmid">{{cite journal | author = Chang MM, Leeman SE, Niall HD | title = Amino-acid sequence of substance P | journal = Nature: New Biology | volume = 232 | issue = 29 | pages = 86–7 | year = 1971 | month = July | pmid = | doi = | url = | issn = | accessdate = 2011-03-31}}</ref><ref name="pmid4613983">{{cite journal | author = Leeman SE, Mroz EA | title = Substance P | journal = Life Sciences | volume = 15 | issue = 12 | pages = 2033–44 | year = 1974 | month = December | pmid = 4613983 | doi = | url = | issn = | accessdate = 2011-03-31}}</ref>:
* [[Arginin|Arg]] [[Prolin|Pro]] [[Lizin|Lys]] [[Prolin|Pro]] [[Glutamin|Gln]] [[Glutamin|Gln]] [[Fenilalanin|Phe]] [[Fenilalanin|Phe]] [[Glicin|Gly]] [[Leucin|Leu]] [[Metionin|Met]]
Supstanca P se oslobađa iz završetaka specifičnih senzornih nerava. Nađena je u mozgu i kičmenoj moždini, i učestvuje u inflamatornim procesima i senzaciji [[bola]].

== Otkriće ==
Supstancu P su originalno otkrili [[1931]] Ulf von Euler i Džon H. Gadum kao extrakt tkiva koji izaziva intestinalne kontrakcije ''in vitro''.<ref name="pmid16994201">{{cite journal | author = V Euler US, Gaddum JH | title = An unidentified depressor substance in certain tissue extracts | journal = The Journal of Physiology | volume = 72 | issue = 1 | pages = 74–87 | year = 1931 | month = June | pmid = 16994201 | pmc = 1403098 | doi =  | url = http://www.jphysiol.org/cgi/pmidlookup?view=long&pmid=16994201 | issn =  }}{{Dead link|date=October 2022 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> Njena distribucija u tkivu i biološka dejstva su detaljno ispitivana tokom decenija koje su sledele.<ref name="pmid11378438"/> NKA (prethodno poznata kao supstanca K ili neuromedin L) je izolovana iz [[svinja|svinjske]] [[kičmena moždina|kičmene moždine]] [[1983]], i ustanovljeno je da takođe stimuliše intestinalne kontrakcije.<ref name="pmid6194276">{{cite journal | author = Panula P, Hadjiconstantinou M, Yang HY, Costa E | title = Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons | journal = The Journal of Neuroscience : the official journal of the Society for Neuroscience | volume = 3 | issue = 10 | pages = 2021–9 | year = 1983 | month = October | pmid = 6194276 | doi = | url = http://www.jneurosci.org/cgi/content/abstract/3/10/2021 | issn = }}</ref>

== Receptor ==
[[Endogen]]i [[receptor (biohemija)|receptor]] supstance P je [[tahikininski receptor 1|neurokininski 1]] receptor (NK1-receptor, NK1R).<ref name="pmid1657150">{{cite journal | author = Gerard NP, Garraway LA, Eddy RL Jr, Shows TB, Iijima H, Paquet JL, Gerard C | title = Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones | journal = Biochemistry | volume = 30 | issue = 44 | pages = 10640–6 | year = 1991 | month = November | pmid = 1657150 | doi = 10.1021/bi00108a006| url =  }}</ref> On pripada familiji [[tahikininski receptor|tahikininskih receptora]] [[G protein spregnuti receptori|G protein-spregnutih receptora]].<ref name="pmid7557266">{{cite journal | author = Maggi CA |title = The mammalian tachykinin receptors | journal = Gen. Pharmacol. | volume = 26 | issue = 5 | pages = 911–44 | year = 1995 | pmid = 7557266 | doi = 10.1016/0306-3623(94)00292-U }}</ref>

== Literatura ==
{{reflist|2}}

== Spoljašnje veze ==
{{Portal-lat|Hemija}}
* {{cite web | url = http://www.fibromyalgiasupport.com/library/showarticle.cfm/id/3097 | title = Neurochemical Substance P is Key to Understanding Pain Process | author = Russell J | authorlink = | coauthors = | date = 14. 09. 2001. | format = | work = Fibromyalgia Library | publisher = ProHealth.com | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 01. 11. 2008. }}
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{{Neuropeptidi-lat}}
{{Neuropeptidni ligandi-lat}}

[[Kategorija:Neuropeptidi]]
[[Kategorija:Neurotransmiteri]]
[[Kategorija:Depresogeni]]