7-hloro-L-triptofan oksidaza
| 7-hloro-L-triptofan oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.3.23 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
7-hloro-L-triptofan oksidaza (EC 1.4.3.23, RebO) je enzim sa sistematskim imenom 7-hloro-L-triptofan:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 7-hloro-L-triptofan + O2 2-imino-3-(7-hloroindol-3-il)propanoat +H2O2
Ovaj enzim sadrži nekovalentno vezani FAD. Ovaj enzim katalizuje prvi korak biosinteze rebekamicina, indolokarbazolnog alkaloida koji formira Actinobakterija Lechevalieria.
- ↑ Nishizawa, T., Aldrich, C.C. and Sherman, D.H. (2005). „Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243”. J. Bacteriol. 187: 2084-2092. PMID 15743957.
- ↑ Howard-Jones, A.R. and Walsh, C.T. (2005). „Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD”. Biochemistry 44: 15652-15663. PMID 16313168.
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
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