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Gliceronfosfat O-aciltransferaza

Izvor: Wikipedija
Gliceron-fosfat O-aciltransferaza
Identifikatori
EC broj 2.3.1.42
CAS broj 37257-19-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
Gliceronfosfat O-aciltransferaza
Identifikatori
Simbol GNPAT
Entrez 8443
Hugo 4416
OMIM 602744
RefSek NM_014236
UniProt O15228
Drugi podaci
EC broj 2.3.1.42
Lokus Hrom. 1 q42

Gliceron-fosfat O-aciltransferaza (EC 2.3.1.42, dihidroksiaceton fosfatna aciltransferaza) je enzim sa sistematskim imenom acil-KoA:gliceron-fosfat O-aciltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

acil-KoA + gliceron fosfat KoA + acilgliceron fosfat

Ovaj enzim je membranski protein. On koristi KoA derivate palmitata, stearata i oleata. Najaktivniji je na palmitoil-KoA.

Gliceronfosfat O-aciltransferaza je enzim vezan za bolest rizomelna hondrodisplazija punktata, tip 2.[4]

Reference

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  1. Ballas, L.M. and Bell, R.M. (1981). „Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles”. Biochim. Biophys. Acta 665: 586-595. PMID 6271231. 
  2. Declercq, P.E., Haagsman, H.P., Van Veldhoven, P., Debeer, L.J., Van Golde, L.M.G. and Mannaerts, G.P. (1984). „Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis”. J. Biol. Chem. 259: 9064-9075. PMID 6746639. 
  3. Hajra, A.K. (1968). „Biosynthesis of acyl dihydroxyacetone phosphate in guinea pig liver mitochondria”. J. Biol. Chem. 243: 3458-3465. PMID 5656381. 
  4. Jan Velišek and Karel Cejpek. „Biosynthesis of Food Constituents: Lipids. 2. Triacylglycerols, Glycerophospholipids, and Glyceroglycolipids”. Czech J. Food Sci. 24: 241–254. 

Literatura

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Spoljašnje veze

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