Ubikvitin-proteinska ligaza
| Ubikvitin-proteinska ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 6.3.2.19 | ||||||||
| CAS broj | 74812-49-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ubikvitin-proteinska ligaza (EC 6.3.2.19, ubikvitin-aktivirajući enzim) je enzim sa sistematskim imenom ubikvitin:protein-lizin N-ligaza (formira AMP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ubikvitin je vezan za ovaj protein peptidnom vezom između C-terminalnog glicina ubikvitina i epsilon-amino grupa lizinskih ostataka proteina.
- ↑ Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982). „Covalent affinity purification of ubiquitin-activating enzyme”. J. Biol. Chem. 257: 2537-2542. PMID 6277904.
- ↑ Haas, A.L. and Rose, I.A. (1982). „The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis”. J. Biol. Chem. 257: 10329-10337. PMID 6286650.
- ↑ Haas, A.L., Warms, J.V.B., Hershko, A. and Rose, I.A. (1982). „Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation”. J. Biol. Chem. 257: 2543-2548. PMID 6277905.
- ↑ Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986). „The protein substrate binding site of the ubiquitin-protein ligase system”. J. Biol. Chem. 261: 11992-11999. PMID 3017957.
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