Muskarinski toksin 7

Muskarinski toksin 7
Muskarinski toksin 7
	Kristalna struktura Muskarinskog toksina 7 (MT7) iz PDB: 2VLW
Identifikatori
Simbol	MT7
SCOP	1F94
SUPERFAMILY	1F94

Muskarinski toksin 7 (MT7) je deo familije malih peptida sa 64 do 66 aminokiselina koja je izolovana iz otrova Afričkih mamba zmija (Dendroaspis angusticeps i Dendroaspis polylepis). Biološki cilj ovog toksina su različiti podtipovi muskarinskog receptora. Muskarinski toksini poput nikotinskih toksina imaju strukturni oblik tri prsta, koji je karakterističan za veliku superfamiliju toksina koji deluju na holinergijskim sinapsama.

Za MT7 je verovatno da se vezuje za ljudski M1 receptor u njegovoj dimernoj formi pri čemu MT7 petlje II i III sadrže hM1 protomer, dok se petlja I vezuje za drugi protomer.^[2]

Reference

^ Fruchart-Gaillard C, Mourier G, Marquer C, Stura E, Birdsall NJ, Servent D (2008). „Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states.”. Mol Pharmacol. 74 (6): 1554—63. PMID 18784346. doi:10.1124/mol.108.050773.
^ Fruchart-Marquer C, Fruchart-Gaillard C, Letellier G, Marcon E, Mourier G, Zinn-Justin S, Ménez A, Servent D, Gilquin B (2011). „Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor.”. J Biol Chem. 286 (36): 31661—75. PMID 21685390. doi:10.1074/jbc.M111.261404.

[pmid18784346-1] Fruchart-Gaillard C, Mourier G, Marquer C, Stura E, Birdsall NJ, Servent D (2008). „Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states.”. Mol Pharmacol. 74 (6): 1554—63. PMID 18784346. doi:10.1124/mol.108.050773.

[pmid21685390-2] Fruchart-Marquer C, Fruchart-Gaillard C, Letellier G, Marcon E, Mourier G, Zinn-Justin S, Ménez A, Servent D, Gilquin B (2011). „Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor.”. J Biol Chem. 286 (36): 31661—75. PMID 21685390. doi:10.1074/jbc.M111.261404.

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