Receptor paratiroidnog hormona 1

Receptor paratiroidnog hormona 1
Receptor paratiroidnog hormona 1
	Prikaz baziran na 1BL1
Dostupne strukture
	1BL1, 3C4M, 3H3G, 3L2J
Identifikatori
Simboli	PTH1R; PFE; PTHR; PTHR1
Vanjski ID	OMIM: 168468 MGI: 97801 HomoloGene: 267 IUPHAR: PTH1 GeneCards: PTH1R Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptora paratiroidnog hormona; • vezivanje peptidnog hormona; • proteinska samoasocijacija;
Celularna komponenta	• jedro; • citoplazma; • ćelijska membrana; • integralno sa ćelijskom membranom; • bazolateralna ćelijska membrana;
Biološki proces	• razvoj skeletalnog sistema; • hondrocitna diferencijacija; • razvoj osteoblasta; • signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	5745
Ensembl	ENSG00000160801
UniProt	Q03431
RefSeq (mRNA)	NM_000316.2
RefSeq (protein)	NP_000307.1
Lokacija (UCSC)	Chr 3:; 46.92 - 46.95 Mb
PubMed pretraga	[1]

Receptor paratiroidnog hormona 1 je protein koji je kod ljudi kodiran PTH1R genom. PTH1R deluje kao receptor za paratiroidni hormon (PTH) i za paratiroidnom hormonu srodan protein (PTHrP, ili PTHLH).

Funkcija

Ovaj „klasični“ PTH receptor je izražen u visokim nivoima u kostima i bubrezima. On reguliše homeostazu jona kalcijuma putem aktivacije adenilat ciklaze i fosfolipaze C.^[1]^[2] U kostima, on je izražen na površini osteoblasta. Kad je receptor aktiviran putem vezivanja PTH, osteoblasti izražavaju RANKL (receptorski aktivator za nuklearni faktor κB ligand), koji se vezuje za RANK (Receptorski aktivator za nuklearni faktor kB) na osteoklastima. Time se osteoklasti aktiviraju da povećaju brzinu resorpcije.

Mehanizam

On je član sekretinske familije G protein spregnutih receptora. Aktivnost ovog receptora je poredovana G_s tipom G proteina koji aktiviraju adenilil ciklazu. Osim toga, oni mogu da aktiviraju fosfatidilinozitol-kalcijumski sistem sekundarnih glasnika.

Interakcije

Receptor paratiroidnog hormona 1 formira interakcije sa regulatornim kofaktorom 2 natrijum-vodonične razmene^[3] i regulatorom 1 natrijum-vodoničnog antiportera 3.^[3]

Reference

^ Mannstadt M, Jüppner H, Gardella TJ (1999). „Receptors for PTH and PTHrP: their biological importance and functional properties”. Am. J. Physiol. 277 (5 Pt 2): F665—75. PMID 10564229. Архивирано из оригинала 13. 02. 2009. г. Приступљено 04. 08. 2012.
^ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). „G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells”. Mol. Endocrinol. 10 (5): 566—74. PMID 8732687. doi:10.1210/me.10.5.566.
^ ^а ^б Mahon, Matthew J; Donowitz Mark; et al. (2002). „Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling”. Nature. England. 417 (6891): 858—61. ISSN 0028-0836. PMID 12075354. doi:10.1038/nature00816.

Literatura

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Vidi još

Receptor paratiroidnog hormona

Spoljašnje veze

„Parathyroid Hormone Receptors: PTH1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 16. 05. 2011. г.
Receptor,+Parathyroid+Hormone,+Type+1 на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid10564229-1] Mannstadt M, Jüppner H, Gardella TJ (1999). „Receptors for PTH and PTHrP: their biological importance and functional properties”. Am. J. Physiol. 277 (5 Pt 2): F665—75. PMID 10564229. Архивирано из оригинала 13. 02. 2009. г. Приступљено 04. 08. 2012.

[pmid8732687-2] Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). „G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells”. Mol. Endocrinol. 10 (5): 566—74. PMID 8732687. doi:10.1210/me.10.5.566.

[pmid12075354-3] а ^б Mahon, Matthew J; Donowitz Mark; et al. (2002). „Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling”. Nature. England. 417 (6891): 858—61. ISSN 0028-0836. PMID 12075354. doi:10.1038/nature00816.

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