Mn(iv) cation encapsulated in the hexahydrazide cage is indefinitely stable in solid state, organ... more Mn(iv) cation encapsulated in the hexahydrazide cage is indefinitely stable in solid state, organic solvents and aqueous solutions.
The synthesis and characterization of mononuclear Co(II) complex based on 3,5-dimethyl-4-amino-1H... more The synthesis and characterization of mononuclear Co(II) complex based on 3,5-dimethyl-4-amino-1H-pyrazole are reported. IR and UV/Vis spectroscopy characterization of the complex are described. The synthesis, results of IR, NMR spectroscopy and elemental analysis of 3,5-dimethyl-4-amino-1H-pyrazole are also reported. X-ray analysis of [Co(C 5 H 9 N 3 ) 2 Cl 2 ] complex reveals that the cobalt atom has a tetrahedral coordination environment formed by two nitrogen atoms belonging to the two 3,5-dimethyl-4-amino-1H-pyrazole ligands [Co1-N1 = 2.005(3) and Co1-N5 = 2.006(3)Å] and two chlorine atoms [Co1-Cl2 = 2.2400( ) and Co1-Cl1 2.2863(12) Å]. In the crystal structure the molecules are linked through intermolecular (N-H•••N, N-H•••Cl) and intramolecular non-classical (С-H•••Cl) hydrogen bonds. Hirshfeld surface analysis of the intermolecular contacts reveals that the most important contributions for the crystal packing are from H•••H (47.1%) and H•••Cl/Cl•••H (28.5%) contacts.
In stitu te o f A p p lie d P hysics o f th e A c ad e m y o f Sciences o f M o ld o v a , 5 G ro... more In stitu te o f A p p lie d P hysics o f th e A c ad e m y o f Sciences o f M o ld o v a , 5 G ro s u l S tre et, 277028 K ish in ev , M o ld o v a Z. N a tu rfo rs c h . 4 8 b , 2 7 0 -2 7 6 (1993); received F e b r u a ry 2 7 /N o v e m b e r 6, 1992 C o b a lt, P yru v y lg ly cin e O xim e, X -R a y , IR S p e c tra , N M R S p e c tra A c o b a lt(I II) c o m p le x w ith py ru v y lg ly cin e oxim e ( H 3G ) o f c o m p o s itio n N a 3[C o G 2] • 9 H 20 is sy n th e size d a n d in v estig a te d by m ea n s o f X -ra y a n aly sis, in fra re d , e le c tro n ic a n d N M R sp ec tro sc o p y . T h e c ry sta ls a re triclinic, sp ace g ro u p P I , a = 15.477(5), = 9.931 (4), c = 7.773(4) Ä; a = 75.60(3); ß = 82.86(4); y = 93.54(3)°; Z = 2. T he s tru c tu re w as refin ed to fin al R = 0.036 fo r 3347 in d e p e n d e n t o b se rv e d reflectio n s. T h e s tru c tu re c o n sists o f th e c o m p le x a n io n s , N a + c a tio n s a n d w a te r m olecules. T h e lig a n d s a re c o o rd in a te d via th e d e p r o to n a te d o x im e a n d a m id e n itro g e n a n d th e c arb o x y l o x ygen a to m s in a m e rid io n a l fa sh io n ( C o -O ( c a r b o x y l) = 1.971 a n d 1 .9 4 7 Ä; C o -N ( o x im e ) = 1.891 a n d 1.909; C o -N ( a m id e ) = 1.876 a n d 1.8 6 6 Ä ). T h e C o (III) c o o rd in a tio n o c ta h e d ro n is slightly d isto rte d ; th e C o -O a n d C o -N d ista n c e s a re in a g re e m e n t w ith th e d a ta fo r oxim e a n d p e p tid e c o m p le x es o f C o (III). T h e u n it cell c o n ta in s 2 e n a n tio m e ric c o m p le x a n io n s re la te d by a c e n te r o f sy m m e try . T h e e le c tro n ic , IR a n d N M R ( 'H a n d 13C ) sp e c tra o f th e co m p lex are c o m p a re d to th o se o f th e free lig a n d a n d o f d ip e p tid a to co m p le x es o f C o (III). * R e p rin t re q u e sts to D r. I. O . F ritsk y . V erlag d e r Z e itsc h rift fü r N a tu rfo rs c h u n g , D -W -7400 T ü b in g e n 0932 -0 7 7 6 /9 3 /0 3 0 0 -0 2 7 0 /$ 0 1 .00/0
Magnetic susceptibility measurements. Magnetic susceptibility measurements were carried out with ... more Magnetic susceptibility measurements. Magnetic susceptibility measurements were carried out with a Quantum-Design MPMS-XL-5 SQUID magnetometer equipped with a 5 T magnet and a MPMS sample space oven over the temperature range 306-420 K with a heating and cooling rate of 2 K min -1 , and a magnetic field of 0.5 T. Diamagnetic correction for the molecule was derived from the Pascal's constants. Mössbauer measurements. Room-temperature 57 Fe-Mössbauer spectra were recorded in transmission geometry with a 57 Co source in a rhodium matrix using a conventional constant-acceleration Mössbauer spectrometer. 3 K spectra were recorded at ESRF using the Synchrotron Mössbauer Source. Isomer shifts are given relatively to an α-Fe foil at ambient temperature. Fits of the experimental Mössbauer data were performed using the Recoil software (Lagarec and Rancourt, Ottawa University). IR spectroscopy. IR spectra were recorded using a Nicolet Nexus spectrometer fitted with a Golden Gate attenuated total reflection accessory (Thermo Nicolet). Spectra were recorded at 4 cm -1 resolution, averaging 16 scans. Thermal analysis. Thermal analysis was performed with DTG-60H Simultaneous TGA/DTA in air flow of 100 ml min -1 within a temperature range 273-873 K. Powder XRD. The samples were analysed with a Siemens D5000 powder diffractometer using Cu-Kα radiation.
Russian Journal of Inorganic Chemistry, Oct 1, 2020
Two novel copper(II) polynuclear complexes with deprotonated 4-iodopyrazole (Ipz) of composition ... more Two novel copper(II) polynuclear complexes with deprotonated 4-iodopyrazole (Ipz) of composition [Cu 3 (μ 3 -OH)(μ-Ipz) 3 Cl 2 • 2CH 3 CN] 2 (1) and [Cu 3 (μ 3 -OH)(μ-Ipz) 3 Br 2 ] n (2) have been synthesized and isolated in crystalline state. Crystal and molecular structure of both compounds has been studied by single crystal X-ray diffraction. The structure of complex 1 consists of dimerized 9-azametallacrown-3 fragments Cu 3 (μ 3 -OH)(μ-Ipz) 3 Cl 2 • 2CH 3 CN connected between each other by chlorine anions. The dimeric molecules are united into polymeric chains with the help of hydrogen bonds between the hydrogen atoms of μ 3 -OH-group and the chlorine anions of the neighboring fragment. Complex 2 is crystallized as polymeric structure, consisting from the trinuclear fragments Cu 3 (μ 3 -OH)(μ-Ipz) 3 Br 2 united by bridging bromine atoms. It is established that in the case of complex 1 the Cu(II) coordination number is complemented up to 5 on account of acetonitrile molecule, whereas in complex 2 the pentacoordinated geometric environment of copper(II) ions is formed by two bridging bromine anions belonging to the neighboring structure subunit.
Acta Crystallographica Section E: Crystallographic Communications, Feb 12, 2019
Crystal structure and magnetic properties of (tris{4-[1-(2-methoxyethyl)imidazol-2-yl]-3-azabut-3... more Crystal structure and magnetic properties of (tris{4-[1-(2-methoxyethyl)imidazol-2-yl]-3-azabut-3-enyl}amine)iron(II) bis(hexafluoridophosphate)
Abstract 1,2,4-triazoles attract attention as actively used medications and ligands for construct... more Abstract 1,2,4-triazoles attract attention as actively used medications and ligands for constructing coordination architectures. In this paper we describe four optically active 4-substituted 1,2,4-triazoles that have been prepared by Bayer's synthesis from the corresponding aliphatic chiral amines. This approach tends to be universal towards different triazoles and permits to conserve a homochirality of substrates. Novel asymmetric molecules have been characterized by spectroscopic techniques and their structures have been retrieved from the single crystal X-ray analysis. Chiro-optical studies of these heterocycles have been made by means of circular dichroism spectroscopy.
Increasing attention has been recently devoted to 89 Zr(IV) and 68 Ga(III) radionuclides, due to ... more Increasing attention has been recently devoted to 89 Zr(IV) and 68 Ga(III) radionuclides, due to their favorable decay characteristics for positron emission tomography (PET). In the present paper, a deep investigation is presented on Ga(III) and Zr(IV) complexes with a series of tri-(H 3 L1, H 3 L3, H 3 L4 and desferrioxamine E, DFOE) and tetrahydroxamate (H 4 L2) ligands. Herein, we describe the rational design and synthesis of two cyclic complexing agents (H 3 L1 and H 4 L2) bearing three and four hydroxamate chelating groups, respectively. The ligand structures allow us to take advantage of the macrocyclic effect; the H 4 L2 chelator contains an additional side amino group available for a possible further conjugation with a biomolecule. The thermodynamic stability of Ga(III) and Zr(IV) complexes in solution has been measured using a combination of potentiometric and pH-dependent UV-vis titrations, on the basis of metal-metal competition. The Zr(IV)-H 4 L2 complex is characterized by one of the highest formation constants reported to date for a tetrahydroxamate zirconium chelate (log β = 45.9, pZr = 37.0), although the complex-stability increase derived from the introduction of the fourth hydroxamate binding unit is lower than that predicted by theoretical calculations. Solution studies on Ga(III) complexes revealed that H 3 L1 and H 4 L2 are stronger chelators in comparison to DFOB. The complex stability obtained with the new ligands is also compared with that previously reported for other hydroxamate ligands. In addition to increasing the library of the thermodynamic stability data of Ga(III) and Zr(IV) complexes, the present work allows new insights into Ga(III) and Zr(IV) coordination chemistry and thermodynamics and broadens the selection of available chelators for 68 Ga(III) and 89 Zr(IV).
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Abstract Spin-crossover (SCO) compounds represent a huge class of switchable coordination complex... more Abstract Spin-crossover (SCO) compounds represent a huge class of switchable coordination complexes that can change their electronic configurations under the influence of different external stimuli. SCO provokes a spectacular switch of physical and chemical properties of complexes making them perspective as active elements of sensors, actuators, electronic and optical components, and other devices. In this article we offer a brief overview of cyanometallic frameworks exhibiting SCO properties. Building blocks that tend to provide new materials with desired spin-crossover characteristics are discussed. Special attention is paid on how the host-guest interactions in SCO frameworks affect their transition properties making them suitable for sensing applications. The effect of size reduction to nanometre scale on switchable properties of cyanometallates is described. Additionally, some outstanding features of SCO cyanometallates such as multistep transitions, mechanical actuation and switchable luminescence are highlighted.
NATO Science for Peace and Security Series B: Physics and Biophysics, 2020
Spin transition complexes form a group of switchable materials that can change their magnetic, op... more Spin transition complexes form a group of switchable materials that can change their magnetic, optical, electric, mechanical and other physical properties under the influence of different external stimuli. New application areas of such materials keep constantly emerging. Here we describe several different developing applications of spin-crossover materials: (a) the change of microwave absorption as a result of spin transition; (b) switchable chirooptical properties of spin-crossover materials exhibiting molecular asymmetry; (c) enantioselective detection via effect of guest chiral molecules on the transition characteristics of chiral spin-crossover frameworks.
Scientific Messenger of LNU of Veterinary Medicine and Biotechnology, Oct 28, 2020
A lot of antianemic drugs for animals are presented on the modern pharmaceutical market of veteri... more A lot of antianemic drugs for animals are presented on the modern pharmaceutical market of veterinary medicine, but they have several drawbacks. So finding new drugs with goal to treat ill animals by anemia and to prevent the iron deficiency anemia is a pressing issue. We previously reported the results of preclinical studies of iron in rare high valence IV. This allowed us to determine, supplement, and generalize the data on clinical studies of the new drugs with the active substance iron (IV) clathrochelate. Therefore, the article presents the results of studies of its antianemic effect on sickling piglets. Experiments were carried out on piglets-analogues neonates, which were divided into three groups: control and two experimental groups. Piglets were kept with sows on suckling. For the purpose of prevention iron deficiency anemia the traditional solution of iron dextran was administered once intramuscularly to piglets of I control group. The aqueous solution of iron (IV) clathrochelate complexes was administered once intramuscularly to piglets of II experimental group. Iron (IV) clathrochelate complexes was dissolved in a solvent of rheopolyglucin and administered once intramuscularly to piglets of III experimental group. 1 mL of test solutions contained 100 mg of active substance. The investigative material were the samples of blood and serum of piglets, their liver and spleen. The experiment lasted during a 30-day period since birth of piglets. According to the results of the experiments, iron (IV) clatrochelate complexes which was dissolved in a water for injection and rheopolyglucin had higher antianemic activity compared to the control. This is evidenced by the dynamics of probable changes in the number of erythrocytes, hemoglobin content and hematocrit, Iron content in serum and its mass fraction in the blood, liver and spleen of piglets. The effectiveness of the action of iron (IV) clatrochelate complexes is explained by the full supply of piglets with iron and its higher bioavailability.
Acta Crystallographica Section E: Crystallographic Communications, Oct 29, 2019
Supporting information: this article has supporting information at journals.iucr.org/e Crystal st... more Supporting information: this article has supporting information at journals.iucr.org/e Crystal structure and Hirshfeld surface analysis of 2,2 0 0 0-{(1E,1 0 0 0 E)-[ethane-1,2-diylbis(azanylylidene)]bis(methanylylidene)}bis[4-(trifluoromethoxy)phenol]copper(II) hydroquinone hemisolvate
Mn(iv) cation encapsulated in the hexahydrazide cage is indefinitely stable in solid state, organ... more Mn(iv) cation encapsulated in the hexahydrazide cage is indefinitely stable in solid state, organic solvents and aqueous solutions.
The synthesis and characterization of mononuclear Co(II) complex based on 3,5-dimethyl-4-amino-1H... more The synthesis and characterization of mononuclear Co(II) complex based on 3,5-dimethyl-4-amino-1H-pyrazole are reported. IR and UV/Vis spectroscopy characterization of the complex are described. The synthesis, results of IR, NMR spectroscopy and elemental analysis of 3,5-dimethyl-4-amino-1H-pyrazole are also reported. X-ray analysis of [Co(C 5 H 9 N 3 ) 2 Cl 2 ] complex reveals that the cobalt atom has a tetrahedral coordination environment formed by two nitrogen atoms belonging to the two 3,5-dimethyl-4-amino-1H-pyrazole ligands [Co1-N1 = 2.005(3) and Co1-N5 = 2.006(3)Å] and two chlorine atoms [Co1-Cl2 = 2.2400( ) and Co1-Cl1 2.2863(12) Å]. In the crystal structure the molecules are linked through intermolecular (N-H•••N, N-H•••Cl) and intramolecular non-classical (С-H•••Cl) hydrogen bonds. Hirshfeld surface analysis of the intermolecular contacts reveals that the most important contributions for the crystal packing are from H•••H (47.1%) and H•••Cl/Cl•••H (28.5%) contacts.
In stitu te o f A p p lie d P hysics o f th e A c ad e m y o f Sciences o f M o ld o v a , 5 G ro... more In stitu te o f A p p lie d P hysics o f th e A c ad e m y o f Sciences o f M o ld o v a , 5 G ro s u l S tre et, 277028 K ish in ev , M o ld o v a Z. N a tu rfo rs c h . 4 8 b , 2 7 0 -2 7 6 (1993); received F e b r u a ry 2 7 /N o v e m b e r 6, 1992 C o b a lt, P yru v y lg ly cin e O xim e, X -R a y , IR S p e c tra , N M R S p e c tra A c o b a lt(I II) c o m p le x w ith py ru v y lg ly cin e oxim e ( H 3G ) o f c o m p o s itio n N a 3[C o G 2] • 9 H 20 is sy n th e size d a n d in v estig a te d by m ea n s o f X -ra y a n aly sis, in fra re d , e le c tro n ic a n d N M R sp ec tro sc o p y . T h e c ry sta ls a re triclinic, sp ace g ro u p P I , a = 15.477(5), = 9.931 (4), c = 7.773(4) Ä; a = 75.60(3); ß = 82.86(4); y = 93.54(3)°; Z = 2. T he s tru c tu re w as refin ed to fin al R = 0.036 fo r 3347 in d e p e n d e n t o b se rv e d reflectio n s. T h e s tru c tu re c o n sists o f th e c o m p le x a n io n s , N a + c a tio n s a n d w a te r m olecules. T h e lig a n d s a re c o o rd in a te d via th e d e p r o to n a te d o x im e a n d a m id e n itro g e n a n d th e c arb o x y l o x ygen a to m s in a m e rid io n a l fa sh io n ( C o -O ( c a r b o x y l) = 1.971 a n d 1 .9 4 7 Ä; C o -N ( o x im e ) = 1.891 a n d 1.909; C o -N ( a m id e ) = 1.876 a n d 1.8 6 6 Ä ). T h e C o (III) c o o rd in a tio n o c ta h e d ro n is slightly d isto rte d ; th e C o -O a n d C o -N d ista n c e s a re in a g re e m e n t w ith th e d a ta fo r oxim e a n d p e p tid e c o m p le x es o f C o (III). T h e u n it cell c o n ta in s 2 e n a n tio m e ric c o m p le x a n io n s re la te d by a c e n te r o f sy m m e try . T h e e le c tro n ic , IR a n d N M R ( 'H a n d 13C ) sp e c tra o f th e co m p lex are c o m p a re d to th o se o f th e free lig a n d a n d o f d ip e p tid a to co m p le x es o f C o (III). * R e p rin t re q u e sts to D r. I. O . F ritsk y . V erlag d e r Z e itsc h rift fü r N a tu rfo rs c h u n g , D -W -7400 T ü b in g e n 0932 -0 7 7 6 /9 3 /0 3 0 0 -0 2 7 0 /$ 0 1 .00/0
Magnetic susceptibility measurements. Magnetic susceptibility measurements were carried out with ... more Magnetic susceptibility measurements. Magnetic susceptibility measurements were carried out with a Quantum-Design MPMS-XL-5 SQUID magnetometer equipped with a 5 T magnet and a MPMS sample space oven over the temperature range 306-420 K with a heating and cooling rate of 2 K min -1 , and a magnetic field of 0.5 T. Diamagnetic correction for the molecule was derived from the Pascal's constants. Mössbauer measurements. Room-temperature 57 Fe-Mössbauer spectra were recorded in transmission geometry with a 57 Co source in a rhodium matrix using a conventional constant-acceleration Mössbauer spectrometer. 3 K spectra were recorded at ESRF using the Synchrotron Mössbauer Source. Isomer shifts are given relatively to an α-Fe foil at ambient temperature. Fits of the experimental Mössbauer data were performed using the Recoil software (Lagarec and Rancourt, Ottawa University). IR spectroscopy. IR spectra were recorded using a Nicolet Nexus spectrometer fitted with a Golden Gate attenuated total reflection accessory (Thermo Nicolet). Spectra were recorded at 4 cm -1 resolution, averaging 16 scans. Thermal analysis. Thermal analysis was performed with DTG-60H Simultaneous TGA/DTA in air flow of 100 ml min -1 within a temperature range 273-873 K. Powder XRD. The samples were analysed with a Siemens D5000 powder diffractometer using Cu-Kα radiation.
Russian Journal of Inorganic Chemistry, Oct 1, 2020
Two novel copper(II) polynuclear complexes with deprotonated 4-iodopyrazole (Ipz) of composition ... more Two novel copper(II) polynuclear complexes with deprotonated 4-iodopyrazole (Ipz) of composition [Cu 3 (μ 3 -OH)(μ-Ipz) 3 Cl 2 • 2CH 3 CN] 2 (1) and [Cu 3 (μ 3 -OH)(μ-Ipz) 3 Br 2 ] n (2) have been synthesized and isolated in crystalline state. Crystal and molecular structure of both compounds has been studied by single crystal X-ray diffraction. The structure of complex 1 consists of dimerized 9-azametallacrown-3 fragments Cu 3 (μ 3 -OH)(μ-Ipz) 3 Cl 2 • 2CH 3 CN connected between each other by chlorine anions. The dimeric molecules are united into polymeric chains with the help of hydrogen bonds between the hydrogen atoms of μ 3 -OH-group and the chlorine anions of the neighboring fragment. Complex 2 is crystallized as polymeric structure, consisting from the trinuclear fragments Cu 3 (μ 3 -OH)(μ-Ipz) 3 Br 2 united by bridging bromine atoms. It is established that in the case of complex 1 the Cu(II) coordination number is complemented up to 5 on account of acetonitrile molecule, whereas in complex 2 the pentacoordinated geometric environment of copper(II) ions is formed by two bridging bromine anions belonging to the neighboring structure subunit.
Acta Crystallographica Section E: Crystallographic Communications, Feb 12, 2019
Crystal structure and magnetic properties of (tris{4-[1-(2-methoxyethyl)imidazol-2-yl]-3-azabut-3... more Crystal structure and magnetic properties of (tris{4-[1-(2-methoxyethyl)imidazol-2-yl]-3-azabut-3-enyl}amine)iron(II) bis(hexafluoridophosphate)
Abstract 1,2,4-triazoles attract attention as actively used medications and ligands for construct... more Abstract 1,2,4-triazoles attract attention as actively used medications and ligands for constructing coordination architectures. In this paper we describe four optically active 4-substituted 1,2,4-triazoles that have been prepared by Bayer's synthesis from the corresponding aliphatic chiral amines. This approach tends to be universal towards different triazoles and permits to conserve a homochirality of substrates. Novel asymmetric molecules have been characterized by spectroscopic techniques and their structures have been retrieved from the single crystal X-ray analysis. Chiro-optical studies of these heterocycles have been made by means of circular dichroism spectroscopy.
Increasing attention has been recently devoted to 89 Zr(IV) and 68 Ga(III) radionuclides, due to ... more Increasing attention has been recently devoted to 89 Zr(IV) and 68 Ga(III) radionuclides, due to their favorable decay characteristics for positron emission tomography (PET). In the present paper, a deep investigation is presented on Ga(III) and Zr(IV) complexes with a series of tri-(H 3 L1, H 3 L3, H 3 L4 and desferrioxamine E, DFOE) and tetrahydroxamate (H 4 L2) ligands. Herein, we describe the rational design and synthesis of two cyclic complexing agents (H 3 L1 and H 4 L2) bearing three and four hydroxamate chelating groups, respectively. The ligand structures allow us to take advantage of the macrocyclic effect; the H 4 L2 chelator contains an additional side amino group available for a possible further conjugation with a biomolecule. The thermodynamic stability of Ga(III) and Zr(IV) complexes in solution has been measured using a combination of potentiometric and pH-dependent UV-vis titrations, on the basis of metal-metal competition. The Zr(IV)-H 4 L2 complex is characterized by one of the highest formation constants reported to date for a tetrahydroxamate zirconium chelate (log β = 45.9, pZr = 37.0), although the complex-stability increase derived from the introduction of the fourth hydroxamate binding unit is lower than that predicted by theoretical calculations. Solution studies on Ga(III) complexes revealed that H 3 L1 and H 4 L2 are stronger chelators in comparison to DFOB. The complex stability obtained with the new ligands is also compared with that previously reported for other hydroxamate ligands. In addition to increasing the library of the thermodynamic stability data of Ga(III) and Zr(IV) complexes, the present work allows new insights into Ga(III) and Zr(IV) coordination chemistry and thermodynamics and broadens the selection of available chelators for 68 Ga(III) and 89 Zr(IV).
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Abstract Spin-crossover (SCO) compounds represent a huge class of switchable coordination complex... more Abstract Spin-crossover (SCO) compounds represent a huge class of switchable coordination complexes that can change their electronic configurations under the influence of different external stimuli. SCO provokes a spectacular switch of physical and chemical properties of complexes making them perspective as active elements of sensors, actuators, electronic and optical components, and other devices. In this article we offer a brief overview of cyanometallic frameworks exhibiting SCO properties. Building blocks that tend to provide new materials with desired spin-crossover characteristics are discussed. Special attention is paid on how the host-guest interactions in SCO frameworks affect their transition properties making them suitable for sensing applications. The effect of size reduction to nanometre scale on switchable properties of cyanometallates is described. Additionally, some outstanding features of SCO cyanometallates such as multistep transitions, mechanical actuation and switchable luminescence are highlighted.
NATO Science for Peace and Security Series B: Physics and Biophysics, 2020
Spin transition complexes form a group of switchable materials that can change their magnetic, op... more Spin transition complexes form a group of switchable materials that can change their magnetic, optical, electric, mechanical and other physical properties under the influence of different external stimuli. New application areas of such materials keep constantly emerging. Here we describe several different developing applications of spin-crossover materials: (a) the change of microwave absorption as a result of spin transition; (b) switchable chirooptical properties of spin-crossover materials exhibiting molecular asymmetry; (c) enantioselective detection via effect of guest chiral molecules on the transition characteristics of chiral spin-crossover frameworks.
Scientific Messenger of LNU of Veterinary Medicine and Biotechnology, Oct 28, 2020
A lot of antianemic drugs for animals are presented on the modern pharmaceutical market of veteri... more A lot of antianemic drugs for animals are presented on the modern pharmaceutical market of veterinary medicine, but they have several drawbacks. So finding new drugs with goal to treat ill animals by anemia and to prevent the iron deficiency anemia is a pressing issue. We previously reported the results of preclinical studies of iron in rare high valence IV. This allowed us to determine, supplement, and generalize the data on clinical studies of the new drugs with the active substance iron (IV) clathrochelate. Therefore, the article presents the results of studies of its antianemic effect on sickling piglets. Experiments were carried out on piglets-analogues neonates, which were divided into three groups: control and two experimental groups. Piglets were kept with sows on suckling. For the purpose of prevention iron deficiency anemia the traditional solution of iron dextran was administered once intramuscularly to piglets of I control group. The aqueous solution of iron (IV) clathrochelate complexes was administered once intramuscularly to piglets of II experimental group. Iron (IV) clathrochelate complexes was dissolved in a solvent of rheopolyglucin and administered once intramuscularly to piglets of III experimental group. 1 mL of test solutions contained 100 mg of active substance. The investigative material were the samples of blood and serum of piglets, their liver and spleen. The experiment lasted during a 30-day period since birth of piglets. According to the results of the experiments, iron (IV) clatrochelate complexes which was dissolved in a water for injection and rheopolyglucin had higher antianemic activity compared to the control. This is evidenced by the dynamics of probable changes in the number of erythrocytes, hemoglobin content and hematocrit, Iron content in serum and its mass fraction in the blood, liver and spleen of piglets. The effectiveness of the action of iron (IV) clatrochelate complexes is explained by the full supply of piglets with iron and its higher bioavailability.
Acta Crystallographica Section E: Crystallographic Communications, Oct 29, 2019
Supporting information: this article has supporting information at journals.iucr.org/e Crystal st... more Supporting information: this article has supporting information at journals.iucr.org/e Crystal structure and Hirshfeld surface analysis of 2,2 0 0 0-{(1E,1 0 0 0 E)-[ethane-1,2-diylbis(azanylylidene)]bis(methanylylidene)}bis[4-(trifluoromethoxy)phenol]copper(II) hydroquinone hemisolvate
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