Papers by Jacques Epelbaum
Psychopharmacology, 2009
Bookmarks Related papers MentionsView impact
Hippocampus, 2009
Bookmarks Related papers MentionsView impact
Progress in Neurobiology, 2009
Bookmarks Related papers MentionsView impact
Neuroscience, 1999
Bookmarks Related papers MentionsView impact
Neuroscience Letters, 1998
Bookmarks Related papers MentionsView impact
Journal of Neurochemistry, 2002
Bookmarks Related papers MentionsView impact
European Journal of Neuroscience, 1998
Bookmarks Related papers MentionsView impact
Endocrinology, 2000
Bookmarks Related papers MentionsView impact
The concentrations of somatostatin in the cortex, hippocampus and caudate nucleus of subjects wit... more The concentrations of somatostatin in the cortex, hippocampus and caudate nucleus of subjects with Parkinson's disease were determined by radioimmunoassay. Somatostatin levels in the frontal cortex were significantly reduced in Parkinsonian subjects who were slightly or severely demented compared to controls and to non-demented Parkinsonians. Significant reductions were also observed in the hippocampus and entorhinal cortex of severely demented subjects.
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Neuromethods, 2012
Bookmarks Related papers MentionsView impact
Research publications - Association for Research in Nervous and Mental Disease, 1978
Bookmarks Related papers MentionsView impact
Journal of neurophysiology, 2000
Hypophysiotropic somatostatin (SRIF) and growth hormone-releasing hormone (GHRH) neurons are prim... more Hypophysiotropic somatostatin (SRIF) and growth hormone-releasing hormone (GHRH) neurons are primarily involved in the neurohormonal control of growth hormone (GH) secretion. They are located in periventricular (PEV) and arcuate (ARC) hypothalamic nuclei, respectively, but their connectivity is not well defined. To better understand the neuronal network involved in the control of GH secretion, connections from PEV to ARC neurons were reconstructed in vitro and neuronal phenotypes assessed by single-cell multiplex RT-PCR. Of 814 stimulated PEV neurons, monosynaptic responses were detected in only 45 ARC neurons. Monosynaptic excitatory currents were detected in 29 ARC neurons and inhibitory currents in 16, indicating a 2/1 ratio for excitatory versus inhibitory connections. Galanin (GAL), NPY, pro-opiomelanocortin (POMC), and SRIF mRNAs were detected in neurons from both nuclei but GHRH mRNA almost exclusively in ARC. Among the five SRIF receptors, only sst1 and sst2 were expressed, ...
Bookmarks Related papers MentionsView impact
The Journal of neuroscience : the official journal of the Society for Neuroscience, Jan 15, 1996
To test the hypothesis of the involvement of centrally expressed rat growth hormone receptors (rG... more To test the hypothesis of the involvement of centrally expressed rat growth hormone receptors (rGH-R) in the ultradian rhythmicity of pituitary GH secretion, adult male rats were submitted to a 60 hr intracerebroventricular infusion of an antisense (AS) oligodeoxynucleotide (ODN) complementary to the sequence of rGH-R mRNA. Eight hour (10 A.M.-6 P.M.) GH secretory profiles, obtained from freely moving male rats infused with 2.0 nmol/hr of rGH-R AS, revealed a marked increase in GH peak amplitude (150 +/- 12 vs 101 +/- 10 ng/ml), trough levels (16.2 +/- 3.0 vs 5.4 +/- 1.4 ng/ml), and number of peaks (2.9 +/- 0.3 vs 1.8 +/- 0.2). No change was observed in rats treated with an ODN complementary to the prolactin receptor mRNA sequence (2.0 nmol/hr). Infusion of increasing ODN concentrations resulted in a dose-dependent stimulation of GH release. In parallel, somatogenic binding sites in the choroid plexus were decreased by 40%, and levels of rGH-R mRNA were increased in the periventricu...
Bookmarks Related papers MentionsView impact
The Journal of biological chemistry, Jan 25, 1986
Despite their opposite effects on prolactin secretion, both dopamine and angiotensin II inhibit a... more Despite their opposite effects on prolactin secretion, both dopamine and angiotensin II inhibit adenylate cyclase activity in homogenates of anterior pituitary cells in primary culture. Dopamine and angiotensin II inhibition of adenylate cyclase was not additive, suggesting that both neurohormones inhibit the adenylate cyclase of the lactotroph cells. Pretreatment with Bordetella pertussis toxin (islet activator protein) completely suppressed the dopamine-induced inhibition of both adenylate cyclase and prolactin secretion. The islet activator protein also reversed the angiotensin II-induced inhibition of the adenylate cyclase activity. In contrast, angiotensin II stimulation of prolactin release was not affected by the toxin. Angiotensin II also induced a dose-dependent stimulation of inositol phosphates (250%) with an EC50 of 0.1 nM, close to that observed for prolactin secretion. Islet activator protein pretreatment did not block the stimulation of inositol phosphate production. ...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Endocrine, 2001
... Marie-Thérèse Bluet-Pajot,1 Virginie Tolle,1 Philippe Zizzari,1 Christophe Robert,1 Constance... more ... Marie-Thérèse Bluet-Pajot,1 Virginie Tolle,1 Philippe Zizzari,1 Christophe Robert,1 Constance Hammond,1 Valérie Mitchell,2 Jean-Claude ... 44. Bellone, J., Aimaretti, G., Bartolotta, E., Benso, L., Imbimbo, BP, Lenhaerts, V., Deghenghi, R., Camanni, F., and Ghigo, E. (1995). ...
Bookmarks Related papers MentionsView impact
Neurobiology of Aging, 2008
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Uploads
Papers by Jacques Epelbaum