Zenodo (CERN European Organization for Nuclear Research), Mar 28, 2023
Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Uroth... more Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Urothelial carcinoma is a common primary tumor of urinary bladder (90%). To investigate the epidemiological and histopathological aspects in Libyan patients suffering from urinary bladder cancer, we performed a study on 39 bladder cancer biopsies from transurethral resection of bladder tumor (TURBT) and cystoscopic samples obtained
OBJECTIVE: The aim of this research is to characterize the most appropriate concentration of Foet... more OBJECTIVE: The aim of this research is to characterize the most appropriate concentration of Foetalbovine serum [FBS] for culture maintenance, and determine the apoptosis rate in the culture system, and also to investigate the induction of proteoglycan catabolism and the role of nitric oxide [NO] on proteoglycans [PG] loss. Furthermore it also aims to study the involvement of specific nitric oxide signaling pathways and to determine the involvement of matrix metalloproteinase [MMPs] in the degradation of proteoglycans. METHODS: Proteoglycan degradation was investigated with 1 μmol/L retinoic acid [RA] and NO donor Diethylenetriamine DETA-NONOate in bovine cartilage explant cultures. Signaling pathways were investigated using specific inhibitors. Nitrite, an end product of NO metabolism, was measured in media by the Griess reaction. Matrix metalloproteinase [MMP] activity was investigated by gelatinase zymography and chondrocyte apoptosis in cultures was assessed using active caspase...
INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS, 2023
Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Uroth... more Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Urothelial carcinoma is a common primary tumor of urinary bladder (90%). To investigate the epidemiological and histopathological aspects in Libyan patients suffering from urinary bladder cancer, we performed a study on 39 bladder cancer biopsies from transurethral resection of bladder tumor (TURBT) and cystoscopic samples obtained from Oncology Department
Open Access Research Journal of Life Sciences, 2023
Ovarian cancer is a growth of cells that forms in the ovaries. The cells multiply quickly and can... more Ovarian cancer is a growth of cells that forms in the ovaries. The cells multiply quickly and can invade and destroy healthy body tissue. Tumors of the ovary are remarkably varied as they may arise from any of the three cell types in the normal ovary. A retrospective study was conducted on 48 cases of ovarian specimens diagnosed as ovarian tumors in the Oncology department at Benghazi Medical Center from January 2020 to December 2021. The files were conducted by the staff members of the Oncology department, and the students divided themselves into groups to obtain the data from the department, the data were age, type of ovarian cancer, histological and cytological reports (microscopic description) and diagnosis. Twelve patients were in the age range 51-60 years old as the highest number followed by the age range 61-70 years of age at 11 patients. Most of the ovarian tumors were seen in patient in postmenopausal age more than 45 years of age with a percentage of 78.7%. Surface epithelial tumors were the most found at followed by metastatic tumors while germ cell tumors were not found in our sample. The most common subtype of ovarian tumors observed in this study was serous cystadenocarcinoma low grade and endometrioid adenocarcinoma, while the least common tumor seen was papillary mucinous cystadenocarcinoma. Concerning the occurrence of bilateral versus unilateral tumors, most of the cases were bilateral. The aim of our research was to study the histological types of ovarian cancer in Benghazi Medical Center in Benghazi-Libya from the years 2020-2021.
Background: Malignant lymphoma is caused by the neoplastic growth of lymphocytes and can manifest... more Background: Malignant lymphoma is caused by the neoplastic growth of lymphocytes and can manifest itself diffusely or in one or more lymph node. Hodgkin lymphoma and non-Hodgkin lymphoma commonly arise from lymphoid tissue. Hodgkin lymphoma is rare B-cell malignant neoplasm it is mainly divided into two main subtype: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin Lymphoma. Non-Hodgkin lymphoma is malignant disorder arising from cell of the immune system and typically present as lymphadenopathy or solid tumor. Objective: Aim of this research is detection of Pediatric lymphoma prevalence and the most common group affected in both age and gender in Children's Hospital-Benghazi. Methods: Cross sectional study was conducted on 59 cases of pediatric lymphoma. The cases were admitted to Children's Hospital-Benghazi. within the time period from January 2014 to May 2023. Data were distributed on the basis of age, gender, year of diagnosis, histological type, and others. Result: The highest number recorded was 9 cases in the years 2017, 2019 and 2020 and the lowest number of cases were at the year 2018 with only 2 cases. The average age of the cases found in the archive was 7.7 year of age. The gender distribution was 41 males, in comparison with only 18 females. The most common type of lymphoma would be Hodgkin lymphoma with 34 cases, histological reports showed the most common subtype of Non-Hodgkin lymphoma was Burkitt lymphoma with 9 cases. Conclusion: Pediatric lymphoma in Children's Hospital Benghazi had a clinical presentation in favor of Hodgkin lymphoma .in this research it was detected the distribution of males was more predominant than females. Most cases found were at 3-4 years of age. medical records showed Stage 3 was the most common stage of the tumor.
Journal of Emerging Technologies and Innovative Research, 2023
Cancer is the second most common cause of mortality among developed countries and the third cause... more Cancer is the second most common cause of mortality among developed countries and the third cause in developing countries. In Benghazi, Libya studies have been rarely prepared. This study aimed to survey all malignant tumor cases concerning important factors including; gender and age, study prevalence of thyroid malignant cases, most common histopathological type, common age group affected, comparison between gender in prevalence by this malignant tumor, and any medical pathology associated with malignant cases. Malignant tumor data from 2002 to 2011 were obtained and studied from the archive of pathology department Benghazi University. The number of cases that have been diagnosed as malignant cases during the given period was 2824, malignant cases in male were accounted for (53.51%) of all malignant cases, while in female was (46.49%), urinary bladder cancer was the most common cancer in males, followed by the prostate and large intestine cancer. Breast cancer, large intestine and uterus cancer were the most common cancers in females. The prevalence of thyroid malignancy in females was around five times more than males and more frequent in middle age groups (30-39) years. This study found that males are more prone to cancer than females, urinary
Female genital tract (FGT) is the most common site for tumors in females. The most common type of... more Female genital tract (FGT) is the most common site for tumors in females. The most common type of (FGT) cancers is cervical, ovarian and endometrial carcinoma. There are other less common tumor's including tumors of the vagina, vulva and fallopian tubes. Cervical cancer is the second most commonly diagnosed cancer worldwide and the fourth leading cause of cancer death in women. To determine the frequency of (FGT) malignancy found at the pathology archive of the Pathology Department at the Faculty of Medicine in the University of Benghazi between the years 2002-2011. Also to define the proportion of cervix cancer cases as compared with other (FGT) that were recorded in the archive. Moreover, to study the histopathological type of cervical cancer, the age groups and at which grades of differentiation are mostly determined. Retrospective histopathological analysis of (FGT) 330 cancer cases diagnosed between (2002-2011). During the reviewing of (FGT) cancer cases of pathology archive all cases of cervical cancer between 2002-2011 were collected and all formalin fixed paraffin-embedded (FFPE) tissue blocks of the patients with cervical cancer in that period were collected, and processed to stained slides. In an analysis of 330 FGT cancer cases registered in the pathology archive. (52%) were carcinoma of the endometrium and this was the commonest. This was followed by the carcinoma of the cervix (30.9%), ovarian tumors (13%), vaginal tumors (2%), fallopian tumors and vulva tumors (1%). The most common type of carcinoma cervix was squamous cell carcinoma (62%), adenocarcinoma was (31%) and the least common type was adenosquamous carcinoma (7%). The mean age of patients was 54.67 years. Most cases presented at the postmenopausal period (62.5%). Most cases were poorly differentiated (47.1%), followed by moderately differentiated (33.3%) and well-differentiated (17.6%).
BACKGROUND: The aim of this work was to study the causes of thyroid nodules, and to review the c... more BACKGROUND: The aim of this work was to study the causes of thyroid nodules, and to review the cytomorphological spectrum of hashimoto’s thyroiditis and correlate it with clinical findings. PATIENTS AND METHODS: this study included post-thyroidectomy patients registered at the endocrine clinic at alkesh polyclinic benghazi, between 2014-2020. the histotechnique procedure was done at the laboratories of the histology department, faculty of medicine. benghazi. RESULTS: the total number of samples were 260 patients, 38 (14.6%) patients were diagnosed as hashimoto’s thyroiditis in which (100%) were females’, the patients age was between the fourth and fifth decade of life. the cytological grades of lymphocytic thyroiditis showed 60.5% of the patients had grade 3 thyroiditis, followed by grade 2 thyroiditis 23.6%. antithyroperoxidase antibodies titer (anti-tpo) was elevated in 24 (36.1%) patients having hashimoto’s thyroiditis and a significant number of patients had hyperthyroidism in which low levels of tsh was seen in 14 (36,8%) patients, 10 (26.3%) patients with hypothyroidism, multinodular goiter was the commonest presentation at clinical examination. CONCLUSION: there was no relation between the cytological grades and the levels of anti-tpo, ft3, ft4 and tsh
International Journal of Frontiers in Life Science Research, 2022
The aim of this study was to study the acute toxic effect of cyclophosphamide on the histological... more The aim of this study was to study the acute toxic effect of cyclophosphamide on the histological structure of the liver tissue in Syrian golden hamsters. Twenty-seven adult female hamsters were injected intraperitoneally with 0, 100 and 200 mg/kg body weight cyclophosphamide. The dosing was administrated on alternating days for one week as an acute dosing schedule and humane sacrifice was done on day 7. Hepatic tissue was collected and processed with paraffin technique for histological examination then stained with hematoxylin and eosin stains (H&E) and Periodic acid-Schiff stain (PAS). The control tissues showed normal histological structure of the liver tissue. With H&E histological changes appeared in the tissue from the hamsters dosed with 100 mg/kg body weight in the form of; slight fatty changes with vacuolated cytoplasm in some areas. The higher dose showed diffuse fatty infiltration, central vein congestion and loss of hepatocyte architecture in addition to sinusoidal congestion. With PAS stain for both low and high doses showed a decrease in glycogen amount due to presence of degenerative hepatocytes and necrosis. We recommend for the patients who undergo long term therapy with cyclophosphamide to perform clinical and biochemical tests at regular intervals to indicate early on any hepatic dysfunction.
Highlights Histopathology is a good way to understand the underlying effects of drugs. Cyclop... more Highlights Histopathology is a good way to understand the underlying effects of drugs. Cyclophosphamide causes nephrotoxicity in the kidneys of female golden hamsters. The cyclophosphamide is dose-dependent. The most significant histological modification of the toxic dose of the cyclophosphamide was tubular necrosis and damage to renal glomeruli.
Scientific Journal of University of Benghazi , 2019
Thirty adult human skulls with full eruption of the third molar teeth were examined to
determine... more Thirty adult human skulls with full eruption of the third molar teeth were examined to determine the anatomy of the greater palatine foramen and canal. Forty computerized tomography scans of the patients were collected to study the location of the greater palatine foramen, direction and length of the greater palatine canal. Dry skulls were differentiated into 14 males and 16 females. Bony results demonstrated that the most common location for the greater palatine foramen was opposite the upper third molar tooth. The most common direction for the greater palatine canal into the oral cavity was anteroinferiorly. In radiological results (CT scan): the mean length of the greater palatine canal was 21.7 mm in males; and 18.1 mm females. The most common location of the greater palatine foramen (GPF) was (1) Opposite the third molar in 45% of the males; and 45% of the females. (2) The next common location was between the second and third molar teeth in 25% of the males; and 30% of the females. (3) Then opposed to the second molar in 20% of the males; and in 25% of the females, (4) Distal to the to the third molar in 10% of the males; and non in females. The direction of the greater palatine canal was anteroinferiorly in 55% of the males; and in 65% of the females. It is concluded that the dentist has to take these anatomical notes with consideration to obtain a successful injection for greater palatine nerve block.
SEBHA UNIVERSITY JOURNAL OF PURE & APPLIED SCIENCES, 2021
In this review, the aim is to discuss the pathological development of vascular calcification incl... more In this review, the aim is to discuss the pathological development of vascular calcification including a brief description of arterial wall structure and function, the development of atherosclerosis, highlighting normal physiological and vascular calcification with particular emphasis on their common characteristics, critically review the recent findings implicating the role of vascular smooth muscle cells in the pathogenesis of the calcification process including the role of microRNAs in regulation of these cells phenotype as a target to control cardiovascular calcification.
Zenodo (CERN European Organization for Nuclear Research), Mar 28, 2023
Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Uroth... more Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Urothelial carcinoma is a common primary tumor of urinary bladder (90%). To investigate the epidemiological and histopathological aspects in Libyan patients suffering from urinary bladder cancer, we performed a study on 39 bladder cancer biopsies from transurethral resection of bladder tumor (TURBT) and cystoscopic samples obtained
OBJECTIVE: The aim of this research is to characterize the most appropriate concentration of Foet... more OBJECTIVE: The aim of this research is to characterize the most appropriate concentration of Foetalbovine serum [FBS] for culture maintenance, and determine the apoptosis rate in the culture system, and also to investigate the induction of proteoglycan catabolism and the role of nitric oxide [NO] on proteoglycans [PG] loss. Furthermore it also aims to study the involvement of specific nitric oxide signaling pathways and to determine the involvement of matrix metalloproteinase [MMPs] in the degradation of proteoglycans. METHODS: Proteoglycan degradation was investigated with 1 μmol/L retinoic acid [RA] and NO donor Diethylenetriamine DETA-NONOate in bovine cartilage explant cultures. Signaling pathways were investigated using specific inhibitors. Nitrite, an end product of NO metabolism, was measured in media by the Griess reaction. Matrix metalloproteinase [MMP] activity was investigated by gelatinase zymography and chondrocyte apoptosis in cultures was assessed using active caspase...
INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS, 2023
Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Uroth... more Urinary bladder cancer is the main reason for morbidity and mortality throughout the world. Urothelial carcinoma is a common primary tumor of urinary bladder (90%). To investigate the epidemiological and histopathological aspects in Libyan patients suffering from urinary bladder cancer, we performed a study on 39 bladder cancer biopsies from transurethral resection of bladder tumor (TURBT) and cystoscopic samples obtained from Oncology Department
Open Access Research Journal of Life Sciences, 2023
Ovarian cancer is a growth of cells that forms in the ovaries. The cells multiply quickly and can... more Ovarian cancer is a growth of cells that forms in the ovaries. The cells multiply quickly and can invade and destroy healthy body tissue. Tumors of the ovary are remarkably varied as they may arise from any of the three cell types in the normal ovary. A retrospective study was conducted on 48 cases of ovarian specimens diagnosed as ovarian tumors in the Oncology department at Benghazi Medical Center from January 2020 to December 2021. The files were conducted by the staff members of the Oncology department, and the students divided themselves into groups to obtain the data from the department, the data were age, type of ovarian cancer, histological and cytological reports (microscopic description) and diagnosis. Twelve patients were in the age range 51-60 years old as the highest number followed by the age range 61-70 years of age at 11 patients. Most of the ovarian tumors were seen in patient in postmenopausal age more than 45 years of age with a percentage of 78.7%. Surface epithelial tumors were the most found at followed by metastatic tumors while germ cell tumors were not found in our sample. The most common subtype of ovarian tumors observed in this study was serous cystadenocarcinoma low grade and endometrioid adenocarcinoma, while the least common tumor seen was papillary mucinous cystadenocarcinoma. Concerning the occurrence of bilateral versus unilateral tumors, most of the cases were bilateral. The aim of our research was to study the histological types of ovarian cancer in Benghazi Medical Center in Benghazi-Libya from the years 2020-2021.
Background: Malignant lymphoma is caused by the neoplastic growth of lymphocytes and can manifest... more Background: Malignant lymphoma is caused by the neoplastic growth of lymphocytes and can manifest itself diffusely or in one or more lymph node. Hodgkin lymphoma and non-Hodgkin lymphoma commonly arise from lymphoid tissue. Hodgkin lymphoma is rare B-cell malignant neoplasm it is mainly divided into two main subtype: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin Lymphoma. Non-Hodgkin lymphoma is malignant disorder arising from cell of the immune system and typically present as lymphadenopathy or solid tumor. Objective: Aim of this research is detection of Pediatric lymphoma prevalence and the most common group affected in both age and gender in Children's Hospital-Benghazi. Methods: Cross sectional study was conducted on 59 cases of pediatric lymphoma. The cases were admitted to Children's Hospital-Benghazi. within the time period from January 2014 to May 2023. Data were distributed on the basis of age, gender, year of diagnosis, histological type, and others. Result: The highest number recorded was 9 cases in the years 2017, 2019 and 2020 and the lowest number of cases were at the year 2018 with only 2 cases. The average age of the cases found in the archive was 7.7 year of age. The gender distribution was 41 males, in comparison with only 18 females. The most common type of lymphoma would be Hodgkin lymphoma with 34 cases, histological reports showed the most common subtype of Non-Hodgkin lymphoma was Burkitt lymphoma with 9 cases. Conclusion: Pediatric lymphoma in Children's Hospital Benghazi had a clinical presentation in favor of Hodgkin lymphoma .in this research it was detected the distribution of males was more predominant than females. Most cases found were at 3-4 years of age. medical records showed Stage 3 was the most common stage of the tumor.
Journal of Emerging Technologies and Innovative Research, 2023
Cancer is the second most common cause of mortality among developed countries and the third cause... more Cancer is the second most common cause of mortality among developed countries and the third cause in developing countries. In Benghazi, Libya studies have been rarely prepared. This study aimed to survey all malignant tumor cases concerning important factors including; gender and age, study prevalence of thyroid malignant cases, most common histopathological type, common age group affected, comparison between gender in prevalence by this malignant tumor, and any medical pathology associated with malignant cases. Malignant tumor data from 2002 to 2011 were obtained and studied from the archive of pathology department Benghazi University. The number of cases that have been diagnosed as malignant cases during the given period was 2824, malignant cases in male were accounted for (53.51%) of all malignant cases, while in female was (46.49%), urinary bladder cancer was the most common cancer in males, followed by the prostate and large intestine cancer. Breast cancer, large intestine and uterus cancer were the most common cancers in females. The prevalence of thyroid malignancy in females was around five times more than males and more frequent in middle age groups (30-39) years. This study found that males are more prone to cancer than females, urinary
Female genital tract (FGT) is the most common site for tumors in females. The most common type of... more Female genital tract (FGT) is the most common site for tumors in females. The most common type of (FGT) cancers is cervical, ovarian and endometrial carcinoma. There are other less common tumor's including tumors of the vagina, vulva and fallopian tubes. Cervical cancer is the second most commonly diagnosed cancer worldwide and the fourth leading cause of cancer death in women. To determine the frequency of (FGT) malignancy found at the pathology archive of the Pathology Department at the Faculty of Medicine in the University of Benghazi between the years 2002-2011. Also to define the proportion of cervix cancer cases as compared with other (FGT) that were recorded in the archive. Moreover, to study the histopathological type of cervical cancer, the age groups and at which grades of differentiation are mostly determined. Retrospective histopathological analysis of (FGT) 330 cancer cases diagnosed between (2002-2011). During the reviewing of (FGT) cancer cases of pathology archive all cases of cervical cancer between 2002-2011 were collected and all formalin fixed paraffin-embedded (FFPE) tissue blocks of the patients with cervical cancer in that period were collected, and processed to stained slides. In an analysis of 330 FGT cancer cases registered in the pathology archive. (52%) were carcinoma of the endometrium and this was the commonest. This was followed by the carcinoma of the cervix (30.9%), ovarian tumors (13%), vaginal tumors (2%), fallopian tumors and vulva tumors (1%). The most common type of carcinoma cervix was squamous cell carcinoma (62%), adenocarcinoma was (31%) and the least common type was adenosquamous carcinoma (7%). The mean age of patients was 54.67 years. Most cases presented at the postmenopausal period (62.5%). Most cases were poorly differentiated (47.1%), followed by moderately differentiated (33.3%) and well-differentiated (17.6%).
BACKGROUND: The aim of this work was to study the causes of thyroid nodules, and to review the c... more BACKGROUND: The aim of this work was to study the causes of thyroid nodules, and to review the cytomorphological spectrum of hashimoto’s thyroiditis and correlate it with clinical findings. PATIENTS AND METHODS: this study included post-thyroidectomy patients registered at the endocrine clinic at alkesh polyclinic benghazi, between 2014-2020. the histotechnique procedure was done at the laboratories of the histology department, faculty of medicine. benghazi. RESULTS: the total number of samples were 260 patients, 38 (14.6%) patients were diagnosed as hashimoto’s thyroiditis in which (100%) were females’, the patients age was between the fourth and fifth decade of life. the cytological grades of lymphocytic thyroiditis showed 60.5% of the patients had grade 3 thyroiditis, followed by grade 2 thyroiditis 23.6%. antithyroperoxidase antibodies titer (anti-tpo) was elevated in 24 (36.1%) patients having hashimoto’s thyroiditis and a significant number of patients had hyperthyroidism in which low levels of tsh was seen in 14 (36,8%) patients, 10 (26.3%) patients with hypothyroidism, multinodular goiter was the commonest presentation at clinical examination. CONCLUSION: there was no relation between the cytological grades and the levels of anti-tpo, ft3, ft4 and tsh
International Journal of Frontiers in Life Science Research, 2022
The aim of this study was to study the acute toxic effect of cyclophosphamide on the histological... more The aim of this study was to study the acute toxic effect of cyclophosphamide on the histological structure of the liver tissue in Syrian golden hamsters. Twenty-seven adult female hamsters were injected intraperitoneally with 0, 100 and 200 mg/kg body weight cyclophosphamide. The dosing was administrated on alternating days for one week as an acute dosing schedule and humane sacrifice was done on day 7. Hepatic tissue was collected and processed with paraffin technique for histological examination then stained with hematoxylin and eosin stains (H&E) and Periodic acid-Schiff stain (PAS). The control tissues showed normal histological structure of the liver tissue. With H&E histological changes appeared in the tissue from the hamsters dosed with 100 mg/kg body weight in the form of; slight fatty changes with vacuolated cytoplasm in some areas. The higher dose showed diffuse fatty infiltration, central vein congestion and loss of hepatocyte architecture in addition to sinusoidal congestion. With PAS stain for both low and high doses showed a decrease in glycogen amount due to presence of degenerative hepatocytes and necrosis. We recommend for the patients who undergo long term therapy with cyclophosphamide to perform clinical and biochemical tests at regular intervals to indicate early on any hepatic dysfunction.
Highlights Histopathology is a good way to understand the underlying effects of drugs. Cyclop... more Highlights Histopathology is a good way to understand the underlying effects of drugs. Cyclophosphamide causes nephrotoxicity in the kidneys of female golden hamsters. The cyclophosphamide is dose-dependent. The most significant histological modification of the toxic dose of the cyclophosphamide was tubular necrosis and damage to renal glomeruli.
Scientific Journal of University of Benghazi , 2019
Thirty adult human skulls with full eruption of the third molar teeth were examined to
determine... more Thirty adult human skulls with full eruption of the third molar teeth were examined to determine the anatomy of the greater palatine foramen and canal. Forty computerized tomography scans of the patients were collected to study the location of the greater palatine foramen, direction and length of the greater palatine canal. Dry skulls were differentiated into 14 males and 16 females. Bony results demonstrated that the most common location for the greater palatine foramen was opposite the upper third molar tooth. The most common direction for the greater palatine canal into the oral cavity was anteroinferiorly. In radiological results (CT scan): the mean length of the greater palatine canal was 21.7 mm in males; and 18.1 mm females. The most common location of the greater palatine foramen (GPF) was (1) Opposite the third molar in 45% of the males; and 45% of the females. (2) The next common location was between the second and third molar teeth in 25% of the males; and 30% of the females. (3) Then opposed to the second molar in 20% of the males; and in 25% of the females, (4) Distal to the to the third molar in 10% of the males; and non in females. The direction of the greater palatine canal was anteroinferiorly in 55% of the males; and in 65% of the females. It is concluded that the dentist has to take these anatomical notes with consideration to obtain a successful injection for greater palatine nerve block.
SEBHA UNIVERSITY JOURNAL OF PURE & APPLIED SCIENCES, 2021
In this review, the aim is to discuss the pathological development of vascular calcification incl... more In this review, the aim is to discuss the pathological development of vascular calcification including a brief description of arterial wall structure and function, the development of atherosclerosis, highlighting normal physiological and vascular calcification with particular emphasis on their common characteristics, critically review the recent findings implicating the role of vascular smooth muscle cells in the pathogenesis of the calcification process including the role of microRNAs in regulation of these cells phenotype as a target to control cardiovascular calcification.
Uploads
Papers by Dr. Abeer Amer
Retrospective histopathological analysis of (FGT) 330 cancer cases diagnosed between (2002-2011). During the reviewing of (FGT) cancer cases of pathology archive all cases of cervical cancer between 2002-2011 were collected and all formalin fixed paraffin-embedded (FFPE) tissue blocks of the patients with cervical cancer in that period were collected, and processed to stained slides. In an analysis of 330 FGT cancer cases registered in the pathology archive. (52%) were carcinoma of the endometrium and this was the commonest. This was followed by the carcinoma of the cervix (30.9%), ovarian tumors (13%), vaginal tumors (2%), fallopian tumors and vulva tumors (1%). The most common type of carcinoma cervix was squamous cell carcinoma (62%), adenocarcinoma was (31%) and the least common type was adenosquamous carcinoma (7%). The mean age of patients was 54.67 years. Most cases presented at the postmenopausal period (62.5%). Most cases were poorly differentiated (47.1%), followed by moderately differentiated (33.3%) and well-differentiated (17.6%).
determine the anatomy of the greater palatine foramen and canal. Forty computerized
tomography scans of the patients were collected to study the location of the greater palatine
foramen, direction and length of the greater palatine canal. Dry skulls were differentiated into
14 males and 16 females. Bony results demonstrated that the most common location for the
greater palatine foramen was opposite the upper third molar tooth. The most common
direction for the greater palatine canal into the oral cavity was anteroinferiorly. In radiological
results (CT scan): the mean length of the greater palatine canal was 21.7 mm in males; and
18.1 mm females. The most common location of the greater palatine foramen (GPF) was (1)
Opposite the third molar in 45% of the males; and 45% of the females. (2) The next common
location was between the second and third molar teeth in 25% of the males; and 30% of the
females. (3) Then opposed to the second molar in 20% of the males; and in 25% of the
females, (4) Distal to the to the third molar in 10% of the males; and non in females. The
direction of the greater palatine canal was anteroinferiorly in 55% of the males; and in 65% of
the females. It is concluded that the dentist has to take these anatomical notes with
consideration to obtain a successful injection for greater palatine nerve block.
Retrospective histopathological analysis of (FGT) 330 cancer cases diagnosed between (2002-2011). During the reviewing of (FGT) cancer cases of pathology archive all cases of cervical cancer between 2002-2011 were collected and all formalin fixed paraffin-embedded (FFPE) tissue blocks of the patients with cervical cancer in that period were collected, and processed to stained slides. In an analysis of 330 FGT cancer cases registered in the pathology archive. (52%) were carcinoma of the endometrium and this was the commonest. This was followed by the carcinoma of the cervix (30.9%), ovarian tumors (13%), vaginal tumors (2%), fallopian tumors and vulva tumors (1%). The most common type of carcinoma cervix was squamous cell carcinoma (62%), adenocarcinoma was (31%) and the least common type was adenosquamous carcinoma (7%). The mean age of patients was 54.67 years. Most cases presented at the postmenopausal period (62.5%). Most cases were poorly differentiated (47.1%), followed by moderately differentiated (33.3%) and well-differentiated (17.6%).
determine the anatomy of the greater palatine foramen and canal. Forty computerized
tomography scans of the patients were collected to study the location of the greater palatine
foramen, direction and length of the greater palatine canal. Dry skulls were differentiated into
14 males and 16 females. Bony results demonstrated that the most common location for the
greater palatine foramen was opposite the upper third molar tooth. The most common
direction for the greater palatine canal into the oral cavity was anteroinferiorly. In radiological
results (CT scan): the mean length of the greater palatine canal was 21.7 mm in males; and
18.1 mm females. The most common location of the greater palatine foramen (GPF) was (1)
Opposite the third molar in 45% of the males; and 45% of the females. (2) The next common
location was between the second and third molar teeth in 25% of the males; and 30% of the
females. (3) Then opposed to the second molar in 20% of the males; and in 25% of the
females, (4) Distal to the to the third molar in 10% of the males; and non in females. The
direction of the greater palatine canal was anteroinferiorly in 55% of the males; and in 65% of
the females. It is concluded that the dentist has to take these anatomical notes with
consideration to obtain a successful injection for greater palatine nerve block.