Retrograde amnesia
Retrograde amnesia (RA) is a loss of memory-access to events that occurred, or information that was learned, before an injury or the onset of a disease
. RA is often temporally graded, consistent with Ribot's Law: subjects are more likely to lose recent memories that are closer to the traumatic incident than more remote memories.
Brain structures
The most commonly affected areas are associated with episodic and declarative memory such as the hippocampus, the diencephalon, and the temporal lobes.
The hippocampus deals largely with memory consolidation, in particular episodic memory. Its main responsibility is making information go from short-term memories into long-term stores. Amnesic patients with damage to the hippocampus are able to demonstrate some degree of unimpaired semantic memory, despite loss of episodic memory, due to spared parahippocampal cortex.
The diencephalon and the surrounding areas' role in memory is not well understood. However, this structure appears to be involved in episodic memory recall.