Evolutionary Developmental Biology

Most contemporary text books of neurology and of psychology pay little attention to the function of the cerebellum beyond noting it to be an organ of motor control. A historical overview of research on cerebellar function is presented, from pre-Sherrinton suggestions of sensory and motor function, through the post-Sherrinton and dominant 20 th . Century view of "motor" function, to the 21 st . century perspective of "sensorimotor" function. The intrinsic capability of the cerebellum is briefly considered in terms of: its size/complexity/capacity; its information representation/processing characteristics (with "a particular computational function"); its sensory information processing capability; and, its role in sensorimotor regulatory control. It is suggested that the cerebellum can process sensorimotor stimulus information in a statistical (connectionist type) manner and respond to in on the basis of its own learning based sensorimotor representations, albeit at a "level" that does not necessarily involve cerebral "awareness".

http://shcyhome.org/2015/01/chc-episode-4-developmental-thinking/
Episode 4 of CHILDHOOD: History & Critique offers a brief review essay of the 2008 book _A Historical Sociology of Childhood_ and an extended conversation with its author - André Turmel, professor emeritus at Laval University.

CHC is a series of interviews, essays, and happenings in historical studies of childhood presented for the Society for the History of Children and Youth.

The early studies of evolutionary developmental biology (Evo-Devo) come from several sources. Tributaries flowing into Evo-Devo came from such disciplines as embryology, developmental genetics, evolutionary biology, ecology, paleontology, systematics, medical embryology and mathematical modeling. This essay will trace one of the major pathways, that from evolutionary embryology to Evo-Devo and it will show the interactions of this pathway with two other sources of Evo-Devo: ecological developmental biology and medical developmental biology. Together, these three fields are forming a more inclusive evolutionary developmental biology that is revitalizing and providing answers to old and important questions involving the formation of biodiversity on Earth. The phenotype of Evo-Devo is limited by internal constraints on what could be known given the methods and equipment of the time and it has been framed by external factors that include both academic and global politics.

We propose a two-step model for the evolutionary origin of the turtle shell. We show here that the carapacial ridge (CR) is critical for the entry of the ribs into the dorsal dermis. Moreover, we demonstrate that the maintenance of the CR and its ability to attract the migrating rib precursor cells depend upon fibroblast growth factor (FGF) signaling. Inhibitors of FGF allow the CR to degenerate, with the consequent migration of ribs along the ventral body wall. Beads containing FGF10 can rearrange rib migration in the chick, suggesting that the CR FGF10 plays an important role in attracting the rib rudiments. The co-ordinated growth of the carapacial plate and the ribs may be a positive feedback loop (similar to that of the limbs) caused by the induction of Fgf8 in the distal tips of the ribs by the FGF10-secreting mesenchyme of the CR. Once in the dermis, the ribs undergo endochrondral ossification. We provide evidence that the ribs act as signaling centers for the dermal ossification and that this ossification is due to bone morphogenetic proteins secreted by the rib. Thus, once the ribs are within the dermis, the ossification of the dermis is not difficult to achieve. This relatively rapid means of carapace formation would allow for the appearance of turtles in the fossil record without obvious intermediates.

BACKGROUND:
In spite of its indusrial usefulness and varied daily uses, lead (Pb) pollution is a widespread ecological problem that faces the humans in the 21th century. Pb was found to produces a wide range of toxic effects including neurotoxicity especially to the developing and young offspring. Recently, the utilization of herbal plants has received a significant attention where there has been rising awareness in their therapeutic use; among these is the garlic.
AIM OF THE WORK:
In light of the above, the current study is designed experimentally in female pregnant rats in order to investigate the beneficial role of garlic extract in the protection from the maternal and fetal cerebellar damage that produced by administration of different doses of Pb during pregnancy.
MATERIALS AND METHODS:
Positively pregnant female rats were divided into five groups; one control group, two Pb-treated groups (exposed to 160 and 320 mg/kg b.wt. of Pb, respectively) and two groups treated with both Pb and garlic (exposed to Pb as previous groups together with 250 mg/ kg b.wt. /day of garlic extract). Treatments started from day 1 till day 20 of pregnancy, where the mother rats of different experimental groups were sacrified to obtain the fetuses. Pb level in the maternal nd fetal blood and cerebellum was estimated by spectrophotometry. Specimens of the cerebellum of different mother and fetal groups were processed to histological and immunohistochemical staining for microscopic examination.
RESULTS:
The results showed that administration of Pb to pregnant rats resulted in a dose-dependent toxicity for both mothers and fetuses in the form of decrease of maternal weight gain, placental and fetal weights, brain weight and diminished fetal growth parameters, which were prominent in rat's group treated with larger dose of Pb. In Pb-treated rats, Pb level in blood and cerebellum was high when compared to the control. The histopathological examination of the cerebellum of treated dams and fetuses showed marked alterations mainly in the form of Purkinje cell degeneration and lack of deveopmet of fetal cerebellum. Co-treatment of garlic extract along with Pb resulted in a significant decrease in Pb levels as compared with those treated with Pb alone with improvement of the histopathological changes.
CONCLUSIONS:
This study was useful in evaluating the hazardous effects of uncontrolled use of Pb in general and in assessing the developmental and neurotoxicity of fetuses due to exposure during pregnancy in particular. Co-administration of garlic has beneficial effects in amelioration of Pb-induced neurotoxicity and reversing the histopathological changes of the cerebellum of mother rats and fetuses.
KEYWORDS:
garlic; glial fibrillary acidic protein; lead; purkinje cells

Concepts of "the self" and "self-awareness", and aspects of the experience of types of consciousness, are explored in terms of "cognitive" systems and their interactions. Some roles of the cerebrum, the cerebellum, and their interactions are considered in relation to sentient consciousness, the sense of self, and conscious regulation of behavior. This 'introductory paper' is composed of modified selected extracts from: totalBRAINtotalMIND Vol.1 : An Integrated Brain/Mind Architecture Part 2: A Cognitive Architecture (pp16 -136) Part 3. Total Brain: structure, development, function, and an integrated neurocognitive architecture (pp137-321). tBtM Vol.1 is now available as an e-book from: http://totalbraintotalmind.co.uk/

Developmental systems theory (DST) is a wholeheartedly
epigenetic approach to development, inheritance and evolution. The developmental system of an organism is the entire matrix of resources that are needed to reproduce the life
cycle. The range of developmental resources that are properly described as being inherited, and which are subject to natural selection, is far wider than has traditionally been allowed. Evolution acts on this extended set of developmental resources. From a developmental systems perspective, development does not proceed according to a preformed plan; what is inherited is much more than DNA; and evolution is change not only in gene
frequencies, but in entire developmental systems.

Viviparity is a reproductive pattern in which females retain developing eggs inside their reproductive tracts or body cavity and give birth to offspring capable of a free-living existence.  Oviparity, in contrast, is a pattern in which females deposit eggs that develop and hatch in the external environment.  These patterns can be viewed as "reproductive strategies," patterns that have advantages as well as disadvantages that affect their evolution.  An advantage of viviparity, for example, is that embryos are protected and physiologically maintained by the pregnant female.  In many viviparous species, the mother provides nutrients to the embryo during gestation, a pattern known as "matrotrophy."  Viviparity has originated on over 160 times among animals and is found among bony fishes, cartilaginous fishes, amphibians, mammals, and squamate reptiles, as well as in several invertebrate groups.  Viviparity and matrotrophy are phenomena of considerable biological interest.  They have been studied from the standpoints of morphology, physiology, endocrinology, ecology, and evolution.

.....the double bind as constituting an entirely new, non-material, principle of evolution, major conceptual revisions may need to be made in our general understanding of evolution as contained within the “modern evolutionary synthesis”.

KEYWORDS:
behavior, communication, context, contradiction, deutero-learning, double bind, epistemology, evolution, incompleteness theorum, kinesics, learning, logical type theory, metacommunication, metamessages, metatheory, mystification, paradox, relationships, schismogenesis, schizophrenia,  scientific elegance, symmathesy, teleology, temporality, transcontextual, transdisciplinary, trauma

In 1858, two naturalists, Charles Darwin and Alfred Russel Wallace, independently proposed natural selection as the basic mechanism responsible for the origin of new phenotypic variants and, ultimately, new species. A large body of evidence for this hypothesis was published in Darwin's Origin of Species one year later, the appearance of which provoked other leading scientists like August Weismann to adopt and amplify Darwin's perspective. Weismann's neo-Darwinian theory of evolution was further elaborated, most notably in a series of books by Theodosius Dobzhansky, Ernst Mayr, Julian Huxley and others. In this article we first summarize the history of life on Earth and provide recent evidence demonstrating that Darwin's dilemma (the apparent missing Precambrian record of life) has been resolved. Next, the historical development and structure of the "modern synthesis" is described within the context of the following topics: paleobiology and rates of evolution, mass extinctions and species selection, macroevolution and punctuated equilibrium, sexual reproduction and recombination, sexual selection and altruism, endosymbiosis and eukaryotic cell evolution, evolutionary developmental biology, phenotypic plasticity, epigenetic inheritance and molecular evolution, experimental bacterial evolution, and computer simulations (in silico evolution of digital organisms). In addition, we discuss the expansion of the modern synthesis, embracing all branches of scientific disciplines. It is concluded that the basic tenets of the synthetic theory have survived, but in modified form. These sub-theories require continued elaboration, particularly in light of molecular biology, to answer openended questions concerning the mechanisms of evolution in all five kingdoms of life. Dedicated to Prof. Dr. Dr. hc mult. Ernst Mayr on the occasion of his 100th birthday U. Kutschera ( ) )

Combining research approaches from biology, philosophy and linguistics, the emerging field of biosemiotics proposes that animals, plants and single cells all engage in semiosis -the conversion of physical signals into conventional signs. This has important implications and applications for issues ranging from natural selection to animal behaviour and human psychology, leaving biosemiotics at the cutting edge of the research on the fundamentals of life.

Previously, in Internet of Life, Chp 1 [137], it was shown that if the interaction protocol between parental genome networks is random then there is a loss of bilateral symmetry. Thus, a nonrandom meta-network, interaction protocol evolved as a precondition for the evolution of the first bilaterally symmetric organisms in the Precambrian more than 570 million years ago. In this chapter we investigate some of the consequence of nonran-dom interaction protocols for development and evolution. Computer simulations show that any nonrandom interaction protocol dynamically partitions the organism into two types of nonintersecting sections, one type controlled by the maternal and the other by the paternal haploid genome network. Thus, at any given time, all cells in a given section are exclusively controlled by only one of the two parental haploid genome networks. The partition is dynamic with sections changing identity, splitting or merging as the organism develops. The developmental effects of later partition states are superposed on earlier developmental states leading to complex mixtures of ancestrally inherited phenotypes. Each protocol has an identifying meta-network signature. Different protocol signatures partition the developing organism differently leading to different morphologies and capacities both mental and physical. As protocols and developmental networks diverge new species and phyla can emerge. Protocols are the bedrock of social and sexual intercourse between male and female genomes. For any diploid species their haploid protocols must cooperate to generate a coherent, complete and consistent embryo. If the two haploid protocols of potential sex partners diverge too much, network disfunction causes developmental pathologies, miscarriage or unviability. Evidence for this new theory of development and evolution comes from computational multicellular experiments, human and animal development , malformations, teratology, hybrids and gynandromorphs. Developmental networks and their meta-network protocols provide a fundamentally new explanatory framework for embryonic and post-embryonic development, developmental pathologies, animal and plant hybrids, heterosis, and evolutionary dynamics.

Apresentação No meio século que vai de 1940 a 1990, o devir da Biologia Evolucionária esteve regido pela Síntese Neodarwiniana. Nesses cinqüenta anos, é verdade, essa síntese enfrentou e respondeu desafios importantes, como aquele colocado pelo surgimento da Biologia Molecular; e ela também se viu sacudida por importantes dissidências internas como as suscitadas pela consolidação da Sistemática Filogenética e pelas relações entre micro e macroevolução. Entretanto, esses desafios e essas polêmicas foram superados sem que nunca se questione o lugar da Teoria da Seleção Natural: esta nunca deixou de ser considerada como a chave articuladora de toda a Biologia Evolucionária. Nas duas últimas décadas, porem, essa situação começou a mudar: sem que seja questionada a importância da seleção natural como força evolutiva, o surgimento desse novo capítulo dos estudos evolucionários que é a Biologia Evolucionária Desenvolvimental parece partir de uma premissa contrária a essa centralidade ou exclusividade da Teoria da Seleção Natural sempre pressuposta no Neodarwinismo.

The present book analyses critically the tripartite mimicry model (consisting of the mimic, model and receiver species) and develops semiotic tools for comparative analysis. It is proposed that mimicry has a double structure where sign relations in communication are in constant interplay with ecological relations between species. Multi-constructivism and toolbox-like conceptual methods are advocated for, as these allow taking into account both the participants’ Umwelten as well as cultural meanings related to specific mimicry cases.

From biosemiotic viewpoint, mimicry is a sign relation, where deceptively similar messages are perceived, interpreted and acted upon. Focusing on living subjects and their communication opens up new ways to understand mimicry. Such view helps to explain the diversity of mimicry as well as mimicry studies and treat these in a single framework. On a meta-level, a semiotic view allows critical reflection on the use of mimicry concept in modern biology.

The author further discusses interpretations of mimicry in contemporary semiotics, analyses mimicry as communicative interaction, relates mimicry to iconic signs and focuses on abstract resemblances in mimicry. Theoretical discussions are illustrated with detailed excursions into practical mimicry cases in nature (brood parasitism, eyespots, myrmecomorphy, etc.). The book concludes with a conviction that mimicry should be treated in a broader semiotic-ecological context as it presumes the existence of ecological codes and other sign conventions in the ecosystem.

We present a general computational theory of cancer and its developmental dynamics. The theory is based on a theory of the architecture and function of developmental control networks which guide the formation of multicellular organisms. Cancer networks are special cases of developmental control networks. Cancer results from transformations of normal developmental networks. Our theory generates a natural classification of all possible cancers based on their network architecture. Each cancer network has a unique topology and semantics and developmental dynamics that result in distinct clinical tumor phenotypes. We apply this new theory with a series of proof of concept cases for all the basic cancer types. These cases have been computationally modeled, their behavior simulated and mathematically described using a multicellular systems biology approach. There are fascinating correspondences between the dynamic developmental phenotype of computationally modeled {\em in silico} cancers a...

This article is a synthesis of current literacy on developmental dyspraxia and aims to alert experts in education from the early-childhood level to the implications of dyspraxia for the child, the family, and the school. The paper posits a clear definition of dyspraxia and clearly identifies common signs and symptoms of dyspraxia. The paper further gives educators specific pointers to the incidence of dyspraxia in preschool and school-age children for effective diagnosis and psychoacademic intervention. The physical, intellectual, emotional, social, language and, sensory implications of dyspraxia for the child, the family and the school is exhaustively discussed. The authors finally reviewed extensively current directions in helping dyspraxic children. Based on the review, the authors conclude that the duty lies heavily on psychoacademics in the school system to identify and address cases of dyspraxia at the earliest onset. The authors recommended, inter alia, that school counsellors employ a tailor-made programme of career education for the dyspraxic as this impairment can seriously interfere with their vocational development.

Darwinism has become an encompassing theory, leaving the confines of science and accounting for all aspects of life. Such an outlook entails important consequences for the evaluation of life. In particular, organisms are considered mere means for species’ preservation and development, while reason is no special faculty, but rather an outgrowth of functions that are rudimentarily present in animals. Darwinism cannot, for that reason, be said to be ‘true’, but if Darwinism is the correct view, the implications for man are grave, no purpose or meaning of life being discernible. Darwinists are accordingly faced with the question why they continue their inquiries.

Recent debates between proponents of the modern evolutionary synthesis (the standard model in evolutionary biology) and those of a possible extended synthesis are a good example of the fascinating tangle among empirical, theoretical, and conceptual or philosophical matters that is the practice of evolutionary biology. In this essay, we briefly discuss two case studies from this debate, highlighting the relevance of philosophical thinking to evolutionary biologists in the hope of spurring further constructive cross-pollination between the two fields.

In recent years, scientists have made remarkable progress reconstructing the animal phylogeny. There is broad agreement regarding many deep animal relationships, including the monophyly of animals, Bilateria, Protostomia, Ecdysozoa, and Spiralia. This stability now allows researchers to articulate the diminishing number of remaining questions in terms of well-defined alternative hypotheses. These remaining questions include relationships at the base of the animal tree, the position of Xenacoelomorpha, and the internal relationships of Spiralia. Recent progress in the field of animal phylogeny has important implications for our understanding of the evolution of development, morphology, genomes, and other characters. A remarkable pattern emerges-there is far more homoplasy for all these characters than had previously been anticipated, even among many complex characters such as segmentation and nervous systems. The fossil record dates most deep branches of the animal tree to an evolutionary radiation in the early Cambrian with roots in the Late Neoproterozoic.

Three experiments revealed that music lessons promote sensitivity to emotions conveyed by speech prosody. After hearing semantically neutral utterances spoken with emotional (i.e., happy, sad, fearful, or angry) prosody, or tone sequences that mimicked the utterances' prosody, participants identified the emotion conveyed. In Experiment 1 (n ‫ס‬ 20), musically trained adults performed better than untrained adults. In Experiment 2 (n ‫ס‬ 56), musically trained adults outperformed untrained adults at identifying sadness, fear, or neutral emotion. In Experiment 3 (n ‫ס‬ 43), 6-year-olds were tested after being randomly assigned to 1 year of keyboard, vocal, drama, or no lessons. The keyboard group performed equivalently to the drama group and better than the no-lessons group at identifying anger or fear.

The emergence of dramatic morphological differences (disparity) and the ensuing bewildering increase in the number of species (diversity) documented in the fossil record at key stages of animal and plant evolution have defied, and still defy, the explanatory powers of Darwin's theory of evolution by natural selection. Among the best examples that have captured the imagination of the layman and the interest of scores of scientists for  years are the origins of land plants from aquatic green plants, of flowering plants from seed plants, of chordates from non-chordates and of tetrapod vertebrates from non-tetrapods; and the conquest of the land by amphibians; the emergence of endotherms from ectotherm animals; the recurrent invention of flight (e.g. in arthropods, birds and mammals) from non-flying ancestors; and the origin of aquatic mammals from fourlegged terrestrial ancestors.

The emergence of dramatic morphological differences (disparity) and the ensuing bewildering increase in the number of species (diversity) documented in the fossil record at key stages of animal and plant evolution have defied, and still defy, the explanatory powers of Darwin's theory of evolution by natural selection. Among the best examples that have captured the imagination of the layman and the interest of scores of scientists for  years are the origins of land plants from aquatic green plants, of flowering plants from seed plants, of chordates from non-chordates and of tetrapod vertebrates from non-tetrapods; and the conquest of the land by amphibians; the emergence of endotherms from ectotherm animals; the recurrent invention of flight (e.g. in arthropods, birds and mammals) from non-flying ancestors; and the origin of aquatic mammals from fourlegged terrestrial ancestors.

This is an epistemologically-driven history of the concept of evolution. Starting from its inception, this work will follow the development of this pregnant concept. However, in contradistinction to previous attempts, the objective will not be the identification of the different meanings it adopted through history, but conversely, it will let the concept to be unfolded, to be explicated and to express its own inner potentialities. The underlying thesis of the present work is, therefore, that the path that leads to the development of the concept of evolution is the path that studies the possibilities of the evolution of concepts, and that the historical reconstruction of its conceptual trajectory will shed light into potential and unexploited possibilities. This methodology will provide useful tools and resources for future developments of the concept. For example, it will define the concept of transmutation as a different conceptual trajectory deviating from the one corresponding to evolution, at the onset of the 19th century. Moreover, epigenesis will not be the opposing concept to evolution, but only to simultaneous and instantaneous generation. It will demonstrate that every important system of epigenesis drew upon some kind of formative power to explain development. More importantly, it will show that the problem of preformation cannot be overlooked, and that some kind of virtual preformation must be considered in order to address the problems of generation and development.

An argument has been raised from various perspectives against the Modern Synthesis (MS) in the past two decades: it has forgotten organisms. Niche construction theorists , developmental biologists like West-Eberhard (2003) and Evo-Devo elaborated various views which concur on a rehabilitation of the explanatory role of organisms, formerly neglected by an evolutionary science mostly centered on genes. This paper aims at assessing such criticisms by unraveling the specific arguments they use and evaluating how empirical findings may support them. In the first section, I review the usual critiques about the way MS treats organisms and show that the organisms-concerned critique is multifaceted, and I use the controversy about units of selection in order to show that purely conceptual and empirical arguments have been mixed up when organisms were concerned. In the second section, I consider successively the challenges raised to evolutionary MS by structuralist biologists and then the developmentalist challenge mostly raised by Evo-Devo. I distinguish what is purely conceptual among those criticisms and what mostly relies on recent empirical findings about genome activation, inheritance, and epigenetics. The last section discusses another program in MS, namely "evolutionary transitions" research, as enquiry into the emergence of organisms.

The history of systematics and evolutionary biology demonstrates how greatly the "modern evolutionary synthesis" instrumentally prevented, rather than facilitated, the intellectual growth and maturity of the diversity of evolutionary disciplines. In truth, the claim of the synthesis being synthetic is essentially without basis, indeed a myth. Instead, the "synthesis" had precisely the opposite effect: namely, squelching the arena of debate, disagreement, and diverse theorizing that had characterized the preceding decades. Although each of the 3 primary architects of the synthesis -Dobzhansky, Mayr, and Simpson -had his own agenda, they were united around the theme of population genetics and population thinking. When applied to systematics, especially by Mayr, the result can now be seen as confused at best. Perhaps this review will provoke a revival of earlier years of intellectual curiosity and fervor, and rekindle interest in systematic method and theory.

This article will utilise Peter Kropotkin’s theory of Mutual Aid to reconsider ontology in International Relations (IR). Mutual Aid Theory holds that the evolution of organisms is shaped by cooperation within a group of species against a variable ecology; thus giving rise to a sociality instinct. This is contrasted with the Malthusian assumption that evolution takes place at the individual level according to their intraspecific fitness. Mutual Aid Theory, applied to the realm of politics, overturns collective-action-problem-grounded theories that hold that the egoistic and competitive drive of humans must be overcome to promote cooperation. Bradley Thayer applied the orthodox individual-fitness interpretation of evolution in an attempt to shore up realist arguments. I argue that such reductionist approaches to studying politics are archaic and not congruent with current scientific understanding. A Critical Realist (CR) approach, placing analytical priority on ontological investigations over epistemological/methodological commitments, is employed to assist in the criticism of orthodox reductionist ontologies. However, equally in line with Kropotkin’s Anarchist ideas, I argue that this critical realist approach also provokes ontologically-driven inquiries into post-sovereignty global politics and can inform the emancipatory intent of Critical IR theory, along side the basic Anarchist ontological claim: society precedes the State.

¿La ciencia ya ha respondido las preguntas fundamentales acerca de los conceptos de vida, cosmos y evolución? ¿Acaso la ciencia no ha relegado estas preguntas fundamentales por el seguimiento de emprendimientos más inmediatos, "útiles" y prácticos, que en última instancia aseguren que la rueda del capitalismo siga girando en su búsqueda frenética del progreso material y económico? Hay algo terriblemente mal en la actual teoría de la evolución, entendida ésta como la teoría darwiniana con sus sucesivas versiones y extensiones. El concepto de selección natural, la piedra angular del darwinismo, es inconsistente lógicamente. Esto ha sido demostrado en algunas de mis últimas publicaciones académicas. Todo el marco conceptual del darwinismo es inadecuado. Los organismos no compiten unos con otros por la supervivencia del más apto. La relación fundamental en la naturaleza no es la competición ni la confrontación, sino la interconectividad, la complementariedad y la significancia relacional. Es necesaria una nueva teoría de la evolución que explique cómo es posible que a partir de organismos tan simples como bacterias, protozoos y diatomeas, se hayan generado organismos tan complejos como los primates y, entre ellos, al ser humano, un ser capaz de sentir y pensar, de sufrir y disfrutar, un ser capaz de tener ideales y propósitos. Una teoría que explique cómo es posible que este ser tan complejo, rico, y hasta cierto punto aún desconocido, haya surgido de una única célula, una célula-huevo, carente de todas las capacidades, riquezas y profundidades de la existencia humana. Una teoría de este tipo ya existe.

Recent historiography of 19th century biology supports the revision of two traditional doctrines about the history of biology. First, the most important and widespread biological debate around the time of Darwin was not evolution versus creation, but biological functionalism versus structuralism. Second, the "idealist" and "typological" structuralist theories of the time were not particularly anti-evolutionary. Typological theories provided argumentation and evidence that was crucial to the refutation of Natural Theological creationism. The contrast between functionalist and structuralist approaches to biology continues today, and the historical misunderstanding of 19th century typological biology may be one of its effects. This historical case can shed light on current controversies regarding the relevance of developmental biology to evolution.

This article will utilise Peter Kropotkin’s theory of Mutual Aid to reconsider ontology in International Relations (IR). Mutual Aid Theory holds that the evolution of organisms is shaped by cooperation within a group of species against a variable ecology; thus giving rise to a sociality instinct. This is contrasted with the Malthusian assumption that evolution takes place at the individual level according to their intraspecific fitness. Mutual Aid Theory, applied to the realm of politics, overturns collective-action-problem-grounded theories that hold that the egoistic and competitive drive of humans must be overcome to promote cooperation. Bradley Thayer applied the orthodox individual-fitness interpretation of evolution in an attempt to shore up realist arguments. I argue that such reductionist approaches to studying politics are archaic and not congruent with current scientific understanding. A Critical Realist (CR) approach, placing analytical priority on ontological investigati...

We review evidence suggesting that mechanisms of information transfers may exist between different channels of inheritance (genetic, epigenetic, behavioural, etc), which is still almost universally regarded as impossible. This has the potential to change our vision of evolution, especially of the role of genes in evolution.

More than 150 years ago, in 1866, Ernst Haeckel published a book in two volumes called Generelle Morphologie der Organismen (General Morphology of Organisms) in the first volume of which he formulated his biogenetic law, famously stating that ontogeny recapitulates phylogeny. Here, we describe Haeckel's original idea as first formulated in the Generelle Morphologie der Organismen and later further developed
in other publications until the present situation in which molecular data are used to test the “hourglass model,” which can be seen as a modern version of the biogenetic law.

While transplantation procedures are often associated with biomedical applications, they are also an invaluable tool for basic research. This review focuses on how transplantation techniques have been used to understand the biology of three large lophotrochozoan phyla: Annelida, Nemertea and Platyhelmintha. I describe how transplantation paradigms have uncovered fundamental principles regarding the embryology, immunology, endocrinology and regeneration biology of representative species within these three groups. In particular, embryologists have used blastomere transplantations to show that both mosaic and regulative development occurs in animals within the phyla. Immunologists have used transplantation techniques to demonstrate that these invertebrates mount a variety of innate immune responses, some of which include surprising features that classically characterize adaptive immunity. Endocrinologists have used transplantation experiments to uncover hormonal requirements for sexual development and maturation. Meanwhile, regeneration biologists continue to address fundamental questions regarding tissue polarity, post-embryonic patterning, stem cell physiology, and the role of the nervous system in regeneration. Along with recent technical and conceptual advances, transplantation remains a powerful tool for invertebrate research.

Current neurobiological understanding of Bruxism (Teeth Grinding) in Autism reveals a non-invasive, permanent cure for this condition based on the cutting-edge sciences of Applied Intentional Epigenetics and Applied Energy Medicine. Read More ...

Echinoderms represent a researchable subset of a dynamic larval evolutionary cosmos. Evolution of echinoderm larvae has taken place over widely varying time scales from the origins of larvae of living classes in the early Palaeozoic, approximately 500 million years ago, to recent, rapid and large-scale changes that have occurred within living genera within a span of less than a million years to a few million years. It is these recent evolutionary events that offer a window into processes of larval evolution operating at a micro-evolutionary level of evolution of discrete develop-mental mechanisms. We review the evolution of the diverse larval forms of living echinoderms to outline the origins of echinoderm larval forms, their diversity among living echinoderms, molecular clocks and rates of larval evolution, and finally current studies on the roles of developmental regulatory mechanisms in the rapid and radical evolutionary changes observed between closely related congeneric species.

One foundational question in contemporary biology is how to 'rejoin' evolution and development. The emerging research program (evolutionary developmental biology or 'evo-devo') requires a meshing of disciplines, concepts, and explanations that have been developed largely in independence over the past century. In the attempt to comprehend the present separation between evolution and development much attention has been paid to the split between genetics and embryology in the early part of the 20 th century with its codification in the exclusion of embryology from the Modern Synthesis. This encourages a characterization of evolutionary developmental biology as the marriage of evolutionary theory and embryology via developmental genetics. But there remains a largely untold story about the significance of morphology and comparative anatomy (also minimized in the Modern Synthesis). Functional and evolutionary morphology are critical for understanding the development of a concept central to evolutionary developmental biology, evolutionary innovation. Highlighting the discipline of morphology and the concepts of innovation and novelty provides an alternative way of conceptualizing the 'evo' and the 'devo' to be synthesized.

professor emeritus of biology at Princeton University, is a leading authority on cellular slime molds and the author of over fifteen books dealing with aspects of biology, including the field now known as "evodevo". Cellular slime molds are fascinating animals/plants/fungi/protistsbiologists have puzzled over their proper taxonomic description since their discovery by Oskar Brefeld in the mid-nineteenth century. They begin their cycle as independent free-living amoebae, but in times of nutritional dearth they aggregate to form a migrating slug; this multicellular slug eventually becomes a very tiny upright fruiting body (about 1 cm high) with a slender stem and spore cap. From this structure spores are dispersed that once again become free-living amoebae. This alternation of generations and behaviourfrom rugged individualism to social cooperation -has a natural appeal for the philosophically minded, and Bonner, in his recent monograph First Signals, attempts to use it to gain insight into the development of more permanently multicellular organisms.