Right Hemisphere Functions

A primary interest of the field of infant mental health is in the early conditions that place infants at risk for less than optimal development. The fundamental problem of what constitutes normal and abnormal development is now a focus of developmental psychology, infant psychiatry, and developmental neuroscience. In the second part of this sequential work, I present interdisciplinary data to more deeply forge the theoretical links between severe attachment failures, impairments of the early development of the right brain's stress coping systems, and maladaptive infant mental health. In the following, I offer thoughts on the negative impact of traumatic attachments on brain development and infant mental health, the neurobiology of infant trauma, the neuropsychology of a disorganized/disoriented attachment pattern associated with abuse and neglect, trauma-induced impairments of a regulatory system in the orbitofrontal cortex, the links between orbitofrontal dysfunction and a predisposition to posttraumatic stress disorders, the neurobiology of the dissociative defense, the etiology of dissociation and body-mind psychopathology, the effects of early relational trauma on enduring right hemispheric function, and some implications for models of early intervention. These findings suggest direct connections between traumatic attachment, inefficient right brain regulatory functions, and both maladaptive infant and adult mental health.

In his 1895 "Project for a Scientific Psychology" Freud attempted to construct a model of the human mind in terms of its underlying neurobiological mechanisms. In this endeavor "to furnish a psychology which shall be a natural science," Freud introduced the concepts that to this day serve as the theoretical foundation and scaffolding of psychoanalysis. As a result, however, of his ensuing disavowal of the Project, these speculations about the fundamental mechanisms that regulate affect, motivation, attention, and consciousness were relegated to the shadowy realm of "metapsychology." Nonetheless, Freud subsequently predicted that at some future date "we shall have to find a contact point with biology." It is argued that recent advances in the interdisciplinary study of emotion show that the central role played by regulatory structures and functions represents such a contact point, and that the time is right for a rapprochement between psychoanalysis and neuroscience. Current knowledge of the psychobiological mechanisms by which the right hemisphere processes social and emotional information at levels beneath conscious awareness, and by which the orbital prefrontal areas regulate affect, motivation, and bodily state, allows for a deeper understanding of the "psychic structure" described by psychoanalytic metapsychology. The dynamic properties and ontogenetic characteristics of this neurobiological system have important implications for both theoretical and clinical psychoanalysis.

Two questions were addressed in the present study: (1) Do autistic and normally developing children exhibit regionally specific differences in electroencephalographic (EEG) activity? (2) Do subgroups of autistic children classified according to Wing and Gould's (1979) system which emphasizes degree of social impairment exhibit distinct patterns of EEG activity? Twenty-eight children with autism (5 to 18 years of age) and two groups of normally developing children (one matched on chronological age and the other on receptive language level) participated. EEG was recorded from left and right frontal, temporal, and parietal regions during an alert baseline condition. Compared to normally developing children, autistic children exhibited reduced EEG power in the frontal and temporal regions, but not in the parietal region. Differences were more prominent in the left than the right hemisphere. Furthermore, subgroups of autistic children based on Wing and Gould's system displayed distinct patterns of brain activity. Compared to autistic children classified as “active-but-odd,” “passive” autistic children displayed reduced alpha EEG power in the frontal region.

The case of a man with a right hemisphere lesion and with evidence of left-sided visuospatial neglect is reported. On a variety of verbal and nonverbal tasks his performance was significantly modified by information implicit in stimulus configurations. Neglect deficits were present on tests involving spatially distinct or meaningless stimulus arrays but almost absent when stimuli were continuous or meaningfully integrated.

We compared the judgment of distance between two simultaneous tactile stimuli applied to different body parts, with judgment of intensity of skin contact of the very same stimulation. Results on normal subjects showed that both tasks bilaterally activate parietal and frontal areas. However, the evaluation of distances on the body surface selectively activated the angular gyrus and the temporo-parieto-occipital junction in the right hemisphere. The different involvement of the brain areas in the two tactile tasks is interpreted as the need for using a Mental Body Representation (MBR) in the distance task, while the judgment of the intensity of skin deflection can be performed without the mediation of the MBR. The present study suggests that the cognitive processes underlying the two tasks are supported by partially different brain networks. In particular, our results show that metric spatial evaluation is lateralized to the right hemisphere.

Cerebral organization during sentence processing in English and in American Sign Language (ASL) was characterized by employing functional magnetic resonance imaging (fMRI) at 4 T. Effects of deafness, age of language acquisition, and bilingualism were assessed by comparing results from (i) normally hearing, monolingual, native speakers of English, (ii) congenitally, genetically deaf, native signers of ASL who learned English late and through the visual modality, and (iii) normally hearing bilinguals who were native signers of ASL and speakers of English. All groups, hearing and deaf, processing their native language, English or ASL, displayed strong and repeated activation within classical language areas of the left hemisphere. Deaf subjects reading English did not display activation in these regions. These results suggest that the early acquisition of a natural language is important in the expression of the strong bias for these areas to mediate language, independently of the form of the language. In addition, native signers, hearing and deaf, displayed extensive activation of homologous areas within the right hemisphere, indicating that the specific processing requirements of the language also in part determine the organization of the language systems of the brain.

Patients with lesions in the right hemisphere often show signs of unilateral neglect for the left side of space. Even in the absence of these signs, however, when exploring a visual scene these patients show an initial orientation of their attention towards the right side . Some patients might be able to compensate for this spatial bias by actively inhibiting the rightward orientation after its occurrence; as a result, they would be capable of extending their exploration to the left part of space. However, due to conflicting demands on the same resource pool, a rightward bias in these patients is expected to reappear or be enhanced when inhibitory mechanisms are used to avoid producing prepotent but inappropriate responses. Eighteen normal controls and 40 right brain-damaged (RBD) patients (17 showing signs of left neglect, 23 without neglect) performed two reaction time tasks requiring manual motor responses to lateralised visual stimuli. In one task, trials in which a motor response was to be withheld (catch trials) were also presented. Regardless of whether they had neglect, patients responded more slowly to left-sided than to right-sided events in both tasks. The presence of catch trials further increased this rightward bias in patients without signs of neglect, but not in neglect patients, consistent with the hypothesis that RBD patients may use inhibitory processes to compensate for spatial bias.

A detailed language assessment was conducted with MM, a 17-year-old bilingual teenager with Rasmussen syndrome who had undergone a left functional hemispherectomy. Results revealed important deficits in French and English, affecting expressive and receptive language in both the written and the oral modality. MMÕs linguistic profile was coherent with previous description of language function following left hemispherectomy, and what is known of the linguistic potential of the right hemisphere (RH). The impairment pattern showed overall similarities between French and English, thus supporting the existence of a common underlying system for these two languages. However, the profiles in each language were not identical, implying that distinct subsystems may also be at play. These findings support previous descriptions of acquired language impairments and recovery in bilingual individuals.

EEG intrahemispheric coherences (HCohs) in the resting state in twenty-four 4 Hz frequency windows between 1 and 51 Hz were studied in 18 children with "non-verbal learning disorder" (NLD) and compared to a group of 18 children with "verbal learning disorder" (VLD). New facts were found in the NLD group. These concern hemispheric balance, expressed as left minus right (L-R) homologous HCohs: 1a). In the high frequencies (25-51 HZ) the number of long-distance HCohs, higher in the right hemisphere (RH), is lower than HCohs, which are higher in the left hemisphere (LH). A reversed interhemispheric asymmetry is seen for short distance HCohs in that band. These asymmetries are not found in the VLD group, and the tendency is even reversed. 1b). In the low frequencies (1-27 Hz) all higher HCohs are more numerous in the RH, irrespective of interelectrode distance (IED). In these bands there are no NLD-VLD group differences; 2). In NLD there is a significant inverse relat...

Simple negation in natural languages represents a complex interrelationship of syntax, prosody, semantics and pragmatics, and may be realised in various ways: lexically, morphologically and prosodically. In almost all spoken languages, the first two of these are the primary realisations of syntactic negation. In contrast, in many signed languages negation can occur without lexical or morphological marking. Thus, in British Sign Language (BSL), negation is obligatorily expressed using face–head actions alone (facial negation) with the option of articulating a manual form alongside the required face–head actions (lexical negation). What are the processes underlying facial negation? Here, we explore this question neuropsychologically. If facial negation reflects lexico-syntactic processing in BSL, it may be relatively spared in people with unilateral right hemisphere (RH) lesions, as has been suggested for other ‘grammatical facial actions’ [Language and Speech 42 (1999) 307; Emmorey, K. (2002). Language, cognition and the brain: Insights from sign language research. Mahwah, NJ: Erlbaum (Lawrence)].Three BSL users with RH lesions were specifically impaired in perceiving facial compared with manual (lexical and morphological) negation. This dissociation was absent in three users of BSL with left hemisphere lesions and different degrees of language disorder, who also showed relative sparing of negation comprehension. We conclude that, in contrast to some analyses [Applied Psycholinguistics 18 (1997) 411; Emmorey, K. (2002). Language, cognition and the brain: Insights from sign language research. Mahwah, NJ: Erlbaum (Lawrence); Archives of Neurology 36 (1979) 837], non-manual negation in sign may not be a direct surface realisation of syntax [Language and Speech 42 (1999) 143; Language and Speech 42 (1999) 127].Difficulties with facial negation in the RH-lesion group were associated with specific impairments in processing facial images, including facial expressions. However, they did not reflect generalised ‘face-blindness’, since the reading of (English) speech patterns from faces was spared in this group. We propose that some aspects of the linguistic analysis of sign language are achieved by prosodic analysis systems (analysis of face and head gestures), which are lateralised to the minor hemisphere.

Several studies have found that patients with left hemi-neglect bisect long lines too far to the right, but bisect short lines too far to the left (the 'cross-over' effect). Some studies have reported that normal participants bisect long lines too far to the left, presumably reflecting an over-estimation of the left side due to the role of the right hemisphere in attention. The purpose of the present series of studies was to further study the cross-over effect in normal participants and to determine whether it may be due to perceptual or motor factors. Participants in the first study showed no cross-over effect on either the traditional line bisection task, or on the purely perceptual Landmark task. However, improvements in the Landmark task in Study 2 did lead to a significant cross-over effect. In Study 3 there was no cross-over on the traditional line bisection task even after changes were made to eliminate the 'ceiling effect' that is usually found with very short lines. Overall, the results suggest that normal participants do show a cross-over effect on a purely perceptual task, but not on the traditional manual line bisection task that includes a motor component. Possible implications for models of right hemispheric involvement in attention are discussed.

The abilities to identify with others and to distinguish between self and other play a pivotal role in intersubjective transactions. Here, we marshall evidence from developmental science, social psychology and neuroscience (including clinical neuropsychology) that support the view of a common representation network (both at the computational and neural levels) between self and other. However, sharedness does not mean identicality, otherwise representations of self and others would completely overlap, and lead to confusion. We argue that self-awareness and agency are integral components for navigating within these shared representations. We suggest that within this shared neural network the inferior parietal cortex and the prefrontal cortex in the right hemisphere play a special role in interpersonal awareness.

We measured cerebral activation with functional magnetic resonance imaging at 3 Tesla while eight healthy volunteers performed various number processing tasks known to be dissociable in brain-lesioned patients: naming, comparing, multiplying, or subtracting single digits. The results revealed the activation of a circuit comprising bilateral intraparietal, prefrontal, and anterior cingulate components. The extension and lateralization of this circuit was modulated by task demands. The intraparietal and prefrontal activation was more important in the right hemisphere during the comparison task and in the left hemisphere during the multiplication task and was intensely bilateral during the subtraction task. Thus, partially distinct cerebral circuits with the dorsal parietal pathway underlie distinct arithmetic operations.

Background: Autoscopic phenomena are psychic illusory visual experiences consisting of the perception of the image of one's own body or face within space, either from an internal point of view, as in a mirror or from an external point of view. Descriptions based on phenomenological criteria distinguish six types of autoscopic experiences: autoscopic hallucination, he-autoscopy or heautoscopic proper, feeling of a presence, out of body experience, negative and inner forms of autoscopy. Methods and results: We report a case of a patient with he-autoscopic seizures. EEG recordings during the autoscopic experience showed a right parietal epileptic focus. This finding confirms the involvement of the temporo-parietal junction in the abnormal body perception during autoscopic phenomena. We discuss and review previous literature on the topic, as different localization of cortical areas are reported suggesting that out of body experience is generated in the right hemisphere while he-autoscopy involves left hemisphere structures.

As individuals who abuse methamphetamine (MA) often exhibit socially maladaptive behaviors such as violence and aggression, it is possible that they respond abnormally to social cues. To investigate this issue, we exposed 12 MA-dependent participants (abstinent 5-16 days) and 12 healthy comparison participants to fearful and angry faces while they performed an affect matching task during functional magnetic resonance imaging (fMRI). Although the groups did not differ in task performance, the healthy participants showed more task-related activity than the MA-dependent participants in a set of cortical regions consisting of the ventrolateral prefrontal cortex (VLPFC), temporoparietal junction (TPJ), anterior and posterior temporal cortex, and fusiform gyrus in the right hemisphere, and the cuneus in the left hemisphere. In contrast, the MA-dependent participants showed more task-related activity than the healthy participants in the dorsal anterior cingulate cortex (dACC). As expected, the task elicited activation of the amygdala in both groups; however, contrary to expectation, we found no difference between groups in this activation. Dorsal ACC hyperactivity, along with high self-ratings of hostility and interpersonal sensitivity in the MA-dependent group, suggest a hyper-sensitivity to socially threatening cues in the MA-dependent participants, while lower VLPFC activation could point to a deficit in integrating socio-emotional information and/or regulating this limbic hyperactivity. Additional activation differences in neural circuitry related to social cognition (TPJ, anterior, and posterior temporal cortex) suggest further socio-emotional deficits. Together, the results point to cortical abnormalities that could underlie the socially inappropriate behaviors often shown by individuals who abuse MA.

Evidence has indicated that the right frontal cortex is preferentially involved in self-face recognition. To test this further, we employed a face identification task and examined hand response differences (N=10). Pictures of famous faces were combined with pictures of the participants’ faces (self) and their co-workers’ faces (familiar). These images were presented as a ‘movie’ in which one face transformed

We investigated whether creative cognition can be improved by means of cognitive and affective stimulation and whether these interventions are associated with changes of EEG alpha activity. Participants were required to generate original uses of conventional objects (Alternative Uses task, AU) while the EEG was recorded. In the cognitive stimulation condition, participants worked on the AU task subsequent to the exposure to other people's ideas. In the affective stimulation condition, they had to think creatively in positive affective states, induced via emotionally contagious sound clips. Creative cognition generally elicited alpha synchronization, most prominent in the prefrontal cortex and in the right hemisphere. The interventions were associated with stronger prefrontal alpha activity in the upper alpha band (10-12 Hz) than the control condition (no intervention), possibly indicating a state of heightened internal awareness, which might have a beneficial impact on creativity.

Recent imaging (e.g., MacSweeney et al., 2002) and lesion (Hickok, Love-GeVen, & Klima, 2002) studies suggest that sign language comprehension depends primarily on left hemisphere structures. However, this may not be true of all aspects of comprehension. For example, there is evidence that the processing of topographic space in sign may be vulnerable to right hemisphere damage (e.g., Hickok, Say, Bellugi, & Klima, 1996), and the inXuence of iconicity on comprehension has yet to be explored. In this study, comprehension testing was conducted with 15 signers with unilateral brain damage, and with elderly Deaf controls. Four tests were administered: a test of iconic and non-iconic noun comprehension, a test of verb and sentence comprehension, a test of locative sentence comprehension, and a test of classiWer comprehension. All tests were administered in British Sign Language (BSL), a language that has only recently been explored with lesioned signers (see

We tested the hypothesis that psychopathy is associated with abnormalities in semantic processing of linguistic information. Functional magnetic resonance imaging (fMRI) was used to elucidate and characterize the neural architecture underlying lexico-semantic processes in criminal psychopathic individuals and in a group of matched control participants. Participants performed a lexical decision task in which blocks of linguistic stimuli alternated with a resting baseline condition. In each lexical decision block, the stimuli were either concrete words and pseudowords or abstract words and pseudowords. Consistent with our hypothesis, psychopathic individuals, relative to controls, showed poorer behavioral performance for processing abstract words. Analysis of the fMRI data for both groups indicated that processing of word stimuli, compared with the resting baseline condition, was associated with neural activation in bilateral fusiform gyrus, anterior cingulate, left middle temporal gyrus, right posterior superior temporal gyrus, and left and right inferior frontal gyrus. Analyses confirmed our prediction that psychopathic individuals would fail to show the appropriate neural differentiation between abstract and concrete stimuli in the right anterior temporal gyrus and surrounding cortex. The results are consistent with other studies of semantic processing in psychopathy and support the theory that psychopathy is associated with right hemisphere abnormalities for processing conceptually abstract material.

It is commonly accepted that phonology is the exclusive domain of the left hemisphere. However, this pattern of lateralization, which posits a right visual field advantage, has been questioned by several studies. In fact, certain factors such as characteristics of the stimuli and subjectsÕ handedness can modulate the right visual field advantage. Thus, the goal of this study was to compare the hemispheric dynamics of right-handers and left-handers during a divided visual field presentation of words that varied in terms of their phonological transparency. For non-transparent words, the left hemisphere seems more competent in both handedness groups. With regard to transparent words, the right hemisphere of both groups also appears competent. Surprisingly, left-handers achieved optimal processing with a functionally isolated left hemisphere, whereas right-handers needed the participation of both hemispheres. The pattern of performance cannot be fully explained by either the callosal or the direct access model.

In addition to repeated reexperiencing of the event, the delayed effects of severe psychological trauma, i.e., post traumatic stress disorder (PTSD), present a paradoxical mix of symptoms. There is enhancement of the self-preservative catecholamine states; anger and fear with a contrasting sense of meaninglessness and a blunting of the emotional responses of the attachment behavior so critical for species preservation. Hormonally, there is a striking separation of the catecholamine response, which stays elevated and that of the hypothalamo-pituitary-adrenal (HPA) axis, which may remain at normal levels. Pathophysiologically, the reexperiencing of the trauma and the arousal may be associated with dysfunction of the locus coeruleus, amygdala and hippocampal systems. This article explores the consequences of an additional dysfunction: a dissociation of the hemispheres that appears to be responsible for the alexithymic avoidance and failure of the cortisol response that so often follow severe psychological trauma. There is neurophysiological evidence that the left and right hemispheres subserve different emotional sets that correspond to “control” and “appraisal,” i.e., very approximately to the self and species preservative behavioral complexes, respectively. Several studies point to physiological dissociation of hemispheric functions during alexithymia. This raises the question: What has been lost if in this condition the right side no longer fully contributes to integrated cerebral function? Right hemispheric damaged children lose critical social skills and in adults the related sense of familiarity critical for bonding is lost. Such losses of social sensibilities may account for the lack of empathy and difficulties with bonding found in sociopathy and borderline personality: conditions now believed to result from repeated psychological trauma during development. On the other hand, systems that promote right hemispheric contributions provide solacing access to a “Higher Power.” They also appear to protect against socially disordered behavior, substance abuse, the failure of the HPA axis and some aspects of the pathophysiology of chronic disease.

Background. Prior research on the nature of the vulnerability of neuroticism to psychopathology suggests biases in information processing towards emotional rather than neutral information. It is unclear to what extent this relationship can be explained by genetic or environmental factors.

The Mini-Mental State Examination (MMSE; M. F. Folstein, S. E. Folstein, & P. R. and the Modified MMSE (E. L. were compared psychometrically. In this study, 525 community-dwelling participants, aged 65-89, were divided into 2 groups: no cognitive impairment (NCI; n -406) and Alzheimer's disease (n = 119). Both tests yielded comparable reliability estimates. Fewer years of education decreased specificity and increased sensitivity, whereas increasing age primarily decreased specificity. It is concluded that although the 2 tests produce comparable effects, the inclusion of a verbal fluency test would increase the sensitivity of the MMSE. Normative data for the NCI group, stratified for 2 age levels (65-79 and 80-89) and 2 educational levels (0-8 and 9+ years), are presented. Folstein, Folstein, and McHugh (1975) introduced the Mini-Mental State Examination (MMSE) as a brief, objective assessment of cognitive functioning and as a measure of changes in cognitive status. The MMSE usually can be administered in 5-10 min and has been employed extensively in clinical settings, community surveys, and epidemiological studies. In a recent review of the literature, Tombaugh and Mclntyre (1992) concluded that the MMSE possessed moderate to high reliability coefficients, demonstrated high levels of sensitivity for cognitive deficits in patients suffering from moderate to severe Alzheimer's disease, and reflected the cognitive decline typical of dementia patients. Criticisms of the MMSE included (a) its failure to discriminate between people with mild dementia and those who are not demented, (b) a limited ability to detect impairment caused by focal lesions, particularly those in the right hemisphere, (c) overly simple language items that reduce sensitivity to mild linguistic deficits, and (d) a large number of false-positive errors because of its bias against individuals with low education. In response to these problems, several attempts have been made to improve the MMSE. Of these, the Modified Mini-Mental State Examination (3MS; Teng & Chui, 1987) represents the most extensive revision. Teng and Chui (1987) added four additional subtests (date and place of birth, word fluency, similarities, and delayed recall of words). The maximum score was

The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately. This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.

Recent evidence suggests that certain types of figurative language, such as conventional metaphors or idioms, may have a left hemisphere processing advantage or are processed similarly in both hemispheres. Sarcasm, however, is likely processed differently than other types of figurative language in the hemispheres because readers often need to construct a novel interpretation of sarcastic text to successfully understand the text's sarcastic meaning. To investigate how the hemispheres process sarcasm during text comprehension, participants in the current study read sarcastic, literal, and neutral texts and made lexical decisions to related target words presented to either the left visual field-right hemisphere or the right visual field-left hemisphere. Facilitation for sarcastic texts was greater in the right hemisphere than the left hemisphere. In addition, facilitation was greater for literal texts than sarcastic texts in the left hemisphere. These findings suggest that the right hemisphere may play a unique role when readers encounter sarcasm during text comprehension.

This review focuses on facial asymmetries during emotional expression. Facial asymmetry is defined as the expression intensity or muscular involvement on one side of the face ("hemiface") relative to the other side and has been used as a behavioral index of hemispheric specialization for facial emotional expression. This paper presents a history of the neuropsychological study of facial asymmetry, originating with Darwin. Both quantitative and qualitative aspects of asymmetry are addressed. Next, neuroanatomical bases for facial expression are elucidated, separately for posed/voluntary and spontaneous/involuntary elicitation conditions. This is followed by a comprehensive review of 49 experiments of facial asymmetry in the adult literature, oriented around emotional valence (pleasantness/unpleasantness), elicitation condition, facial part, social display rules, and demographic factors. Results of this review indicate that the left hemiface is more involved than the right hemiface in the expression of facial emotion. From a neuropsychological perspective, these findings implicate the right cerebral hemisphere as dominant for the facial expression of emotion. In spite of the compelling evidence for right-hemispheric specialization, some data point to the possibility of differential hemispheric involvement as a function of emotional valence.

We report the case of a 10-year-old boy with pharmacoresistant epilepsy, symptomatic of a right temporoparietal hemorrhagic lesion, who displayed an eating passion as described for the gourmand syndrome (GS) in adults and discuss the role of epilepsy in GS. This patient presented with a significant change in his eating habits (abnormal preoccupation with the preparation and eating of fine-quality food) concordant with the onset of his seizure disorder, without any previous history of eating disorders or psychiatric illness. This observation corroborates the important role of the right cerebral hemisphere in disturbed eating habits, including the relatively benign GS, and, possibly rarely, in less benign eating disorders such as anorexia and obesity.

Performing music requires fast auditory and motor processing. Regarding professional musicians, recent brain imaging studies have demonstrated that auditory stimulation produces a co-activation of motor areas, whereas silent tapping of musical phrases evokes a co-activation in auditory regions. Whether this is obtained via a specific cerebral relay station is unclear. Furthermore, the time course of plasticity has not yet been addressed. Changes in cortical activation patterns (DC-EEG potentials) induced by short (20 minute) and long term (5 week) piano learning were investigated during auditory and motoric tasks. Two beginner groups were trained. The 'map' group was allowed to learn the standard piano key-to-pitch map. For the 'no-map' group, random assignment of keys to tones prevented such a map. Auditory-sensorimotor EEG co-activity occurred within only 20 minutes. The effect was enhanced after 5-week training, contributing elements of both perception and action ...

Twenty individuals solved a visual oddball task in two response conditions: while listening to the Mozart's sonata K. 448, and while listening to nothing. The recorded event-related potentials (ERP) were analyzed in the time and frequency domains. In the music response condition the ERP peak latencies on the left hemisphere increased, whereas on the right hemisphere a decrease of peak latencies as compared with the silence response condition was observed. In the theta, lower-1 alpha and gamma band increases in induced event-related coherences were observed while respondents solved the oddball task and listened to music, whereas a decoupling of brain areas in the gamma band was observed in the silence response condition. It is suggested that auditory background stimulation can influence visual brain activity, even if both stimuli are unrelated.

Objective: Spatial neglect results in an ipsilesional misorientation of attention in visual-spatial tasks. Hemianopia impairs visual perception but its influence on visual-spatial tasks is subject to debate. Here, we investigated the influence of the time since stroke on the respective impacts of hemianopia and spatial neglect. Method: A total of 29 patients with a right hemisphere stroke were included in the study. Nine had severe neglect and hemianopia, six had severe neglect only, four showed hemianopia with little or no neglect after infarction of the posterior cerebral artery, and 10 had neither neglect nor hemianopia. We investigated the spatial bias in the subjective straight ahead (SSA) test and in clinical tests (bell cancellation, line bisection, and scene copy). Each task was administered twice (at S1 and S2: 41.4 and 67.2 days [on average] after the stroke, respectively). Results: At S1, spatial neglect and hemianopia had an additive influence on SSA test performance (rightward translation). Similar rightward biases were observed in the clinical tests. At S2, the influence of hemianopia had disappeared, whereas that of neglect was still present. Furthermore, loss of bias in the SSA test correlated with the improvements seen in most of the clinical tests. Conclusions: In patients with recent stroke, hemianopia aggravates the visual-spatial bias when neglect is present or may lead to visual-neglect-like behavior when classically defined neglect is absent. However, the influence of hemianopia disappears relatively quickly over time, due to compensation.

AbstractÐAnalyses of scalp-recorded sleep spindles have demonstrated topographically distinct slow and fast spindle waves. In the present paper, the electrical activity in the brain corresponding to different types of sleep spindles was estimated by means of low-resolution electromagnetic tomography. In its new implementation, this method is based on realistic head geometry and solution space is restricted to the cortical gray matter and hippocampus. In multichannel allnight electroencephalographic recordings, 10±20 artifact-free 1.25-s epochs with frontally, parietally and approximately equally distributed spindles were marked visually in 10 normal healthy subjects aged 20±35 years. As a control condition, artifact-free non-spindle epochs 1±3 s before or after the corresponding spindle episodes were marked. Low-resolution electromagnetic tomography demonstrated, independent of the scalp distribution, a distributed spindle source in the prefrontal cortex (Brodmann areas 9 and 10), oscillating with a frequency below 13 Hz, and in the precuneus (Brodmann area 7), oscillating with a frequency above 13 Hz. In extremely rare cases only the prefrontal or the parietal source was active. Brodmann areas 9 and 10 have principal connections to the dorsomedial thalamic nucleus; Brodmann area 7 is connected to the lateroposterior, laterodorsal and rostral intralaminar centrolateral thalamic nuclei. Thus, the localized cortical brain regions are directly connected with adjacent parts of the dorsal thalamus, where sleep spindles are generated.

This study examined the effects of right brain-damage (RBD) on oral discourse production using a multi-layered discourse processing model. Narrative and procedural discourse samples from participants with RBD and no brain damage were analysed in terms of seven broad areas corresponding to the processing levels of the model. Participants also completed attention, cognitive, general communication and RBD assessments. Despite their normal performance on all assessments (except those on attention), the participants with RBD demonstrated statistically significant differences in syntactic complexity, clarity disruptors and dysfluencies, as well as in discourse grammar and clausal structure in the narratives and in cohesion in the procedures. A model-based theoretical explanation accounting for the deficits noted in participants with RBD, together with clinical guidelines, is provided.

Over the last ten years the basic knowledge of brain structure and function has vastly expanded, and its incorporation into the developmental sciences is now allowing for more complex and heuristic models of human infancy. In a continuation of this effort, in this two-part work I integrate current interdisciplinary data from attachment studies on dyadic affective communications, neuroscience on the early developing right brain, psychophysiology on stress systems, and psychiatry on psychopathogenesis to provide a deeper understanding of the psychoneurobiological mechanisms that underlie infant mental health. In this article I detail the neurobiology of a secure attachment, an exemplar of adaptive infant mental health, and focus upon the primary caregiver's psychobiological regulation of the infant's maturing limbic system, the brain areas specialized for adapting to a rapidly changing environment. The infant's early developing right hemisphere has deep connections into the limbic and autonomic nervous systems and is dominant for the human stress response, and in this manner the attachment relationship facilitates the expansion of the child's coping capcities. This model suggests that adaptive infant mental health can be fundamentally defined as the earliest expression of flexible strategies for coping with the novelty and stress that is inherent in human interactions. This efficient right brain function is a resilience factor for optimal development over the later stages of the life cycle.

To describe the morphological stages of insular sulci and gyri development we carried out a macroscopical study on 21 human fetal brains, showing no anomalies, from 13 to 28 gestational weeks (GWs). Particular focus was given to morphological appearance during the development of insular and periinsular structures, especially the gyration and sulcation of the insula, central cerebral region and opercula, as well as the vascularization of these regions. The periinsular sulci and the central (insular and cerebral) sulci were the first macroscopical structures identified on the lateral surface of the human fetal cerebral hemisphere with earlier development on the right hemisphere. Here we describe five stages of insular gyral and sulcal development closely related to gestational age: stage 1: appearance of the first sulcus at 13-17 GWs, stage 2: development of the periinsular sulci at 18–19 GWs, stage 3: central sulci and opercularization of the insula at 20–22 GWs, stage 4: covering of the posterior insula at 24–26 GWs, stage 5: closure of the sylvian fissure at 27–28 GWs. We provide evidence that cortical maturation (sulcation and gyration) and vascularization of the lateral surface of the brain starts with the insular region, suggesting that this region is a central area of cortical development.

The neural correlates of left extrapersonal visual unilateral spatial neglect (VUSN), the more extensively investigated component of the neglect syndrome, are reviewed. Damage to a number of righthemisphere regions brings about VUSN: the posterior parietal cortex (inferior parietal lobule) and, although less frequently, the premotor cortex and subcortical structures, such as the thalamus and the basal ganglia, and white matter fiber tracts. In recent years, a number of studies have investigated the possible association of specific components of left VUSN with damage to specific brain regions within the right hemisphere. The putative distinction most extensively investigated from an anatomical perspective concerns the perceptual vs premotor components of VUSN. In addition, a fine-grain componential analysis of the behavioral tasks used to investigate VUSN is providing more specific insight into the pathological mechanisms underlying the variety of its manifestations. The emerging pattern is that USN is a multifarious disorder, in which specific deficits are associated with damage localized in discrete brain regions and neural circuits. These data concur with evidence from other domains (functional neuroimaging, neurophysiology) to suggest a highly multicomponential neural and functional architecture of spatial cognition.

We know from animal studies that a stimulating and enriched environment can enhance recovery after stroke, but little is known about the effects of an enriched sound environment on recovery from neural damage in humans. In humans, music listening activates a wide-spread bilateral network of brain regions related to attention, semantic processing, memory, motor functions, and emotional processing. Music exposure also enhances emotional and cognitive functioning in healthy subjects and in various clinical patient groups. The potential role of music in neurological rehabilitation, however, has not been systematically investigated. This single-blind, randomized, and controlled trial was designed to determine whether everyday music listening can facilitate the recovery of cognitive functions and mood after stroke. In the acute recovery phase, 60 patients with a left or right hemisphere middle cerebral artery (MCA) stroke were randomly assigned to a music group, a language group, or a control group. During the following two months, the music and language groups listened daily to self-selected music or audio books, respectively, while the control group received no listening material. In addition, all patients received standard medical care and rehabilitation. All patients underwent an extensive neuropsychological assessment, which included a wide range of cognitive tests as well as mood and quality of life questionnaires, one week (baseline), 3 months, and 6 months after the stroke. Fifty-four patients completed the study. Results showed that recovery in the domains of verbal memory and focused attention improved significantly more in the music group than in the language and control groups.The music group also experienced less depressed and confused mood than the control group. These findings demonstrate for the first time that music listening during the early post-stroke stage can enhance cognitive recovery and prevent negative mood. The neural mechanisms potentially underlying these effects are discussed.

The acclaimed Italian directors Luchino Visconti and Federico Fellini had very different life trajectories that led them to become major figures in the history of cinema. Similarities, however, can be found in their debuts with the neorealist genre, their personalities, creative styles and politicocultural involvement, and ultimately in the neurological disease that struck them at the end of their careers. Both suffered a right-hemispheric stroke that left them hemiplegic on the left side. We review their life and career to put that event into perspective, and then discuss its aftermath for both artists in the light of our current knowledge of right-hemispheric functions. Visconti showed a tremendous resilience following the accident and managed to direct several films and plays as an infirm, whereas Fellini had to put an end to his career but still was able to display his talents to the neuropsychologists that treated him. A speculative account is given of the links between right-hemispheric symptomatology and the premorbid personality of these highly prolific patients.

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Verbal and nonverbal communication are seen in terms of interacting streams of spontaneous and symbolic communication, and posed "pseudo-spontaneous" displays. Spontaneous communication is defined as the nonintentional communication of motivational-emotional states based upon biologically shared nonpropositional signal systems, with information transmitted via displays. Symbolic communication is the intentional communication, using learned, socially shared signal systems, of propositional information transmitted via symbols. Pseudospontaneous communication involves the intentional and strategic manipulation of displays. An original meta-analysis demonstrates that, like verbal symbolic communication, nonverbal analogic (pantomimic) communication is related to left hemisphere cerebral processing. In contrast, spontaneous communication is related to the right hemisphere.

There have been multiple historical and cross-cultural reports of excess correlation of specific experiences between individuals separated by thousands of kilometers. Recently there have been experimental demonstrations of excess correlations between measurable cerebral events for small percentages of test subjects. More reliable effects can be elicited when electromagnetic fields and photons are involved. In this experiment completed during the summer of 2015, 5 pairs of volunteers separated by more than 6,000 km wore identical cerebral toroids through which patterns of phase shifting, 30 nT magnetic fields that diminished the local magnetic field in both loci by 1-5 nT were exposed to the sequences that produced excess correlation in chemiluminescent reactions and shifts in pH. Compared to the various baselines and control procedures enhanced power between the right hemispheres of pairs of participants occurred during the interval documented to produce excess correlation. Specific analyses indicated diminished coherence within the theta band only within the right temporal lobes of the pairs. Sequential block analyses revealed that the paired brains’ responses to pulsed tones at 6.5 Hz occurred within the 30-40 Hz band over the caudal temporal lobes during the exposures to the effector field. Primary independent component analyses verified these patterns. During the 6.5 Hz tones there was a peak in the spectral power density (SPD) at that frequency over the right temporal lobe of the person listening but a trough in (SPD) over this region for the person who was not. Even subjective experiences, as measured by the Profile of Mood States (POMS), indicated significantly increased excess correlation for scales by which increased anger and decreased vigour are inferred. This experiment, based upon physical principles, suggests there is a technology that can generate reliable excess correlation of brain activity (and potentially consciousness and specific experiences) between two people separated by thousands of kilometers.