Origin and history of prophase

1705, "phase of the moon, particular recurrent appearance presented by the moon (or Mercury or Venus) at a particular time," back-formed as a singular from Modern Latin phases, plural of phasis, from Greek phasis "appearance" (of a star), "phase" (of the moon), from stem of phainein "to show, to make appear" (from PIE root *bha- (1) "to shine").

Latin singular phasis was used in English from 1660 for each of the aspects of the moon. General (non-lunar) sense of "aspect, appearance, stage of development at a particular time" is attested by 1841. Meaning "temporary difficult period" (especially in reference to adolescents) is attested from 1913.

word-forming element meaning "forward, forth, toward the front" (as in proclaim, proceed); "beforehand, in advance" (prohibit, provide); "taking care of" (procure); "in place of, on behalf of" (proconsul, pronoun); from Latin pro (adv., prep.) "on behalf of, in place of, before, for, in exchange for, just as," which also was used as a first element in compounds and had a collateral form por-.

Also in some cases from cognate Greek pro "before, in front of, sooner," which also was used in Greek as a prefix (as in problem). Both the Latin and Greek words are from PIE *pro- (source also of Sanskrit pra- "before, forward, forth;" Gothic faura "before," Old English fore "before, for, on account of," fram "forward, from;" Old Irish roar "enough"), extended form of root *per- (1) "forward," hence "in front of, before, toward, near," etc.

The common modern sense of "in favor of, favoring" (pro-independence, pro-fluoridation, pro-Soviet, etc.) was not in classical Latin and is attested in English from early 19c.