A 24-year-old white woman with suspected PK deficiency had suffered a haemolytic episode immediately after the prophylactic use of antiretrovirals (3TC, AZT and
Crixivan) a year earlier.
(43.) Merck announces compassionate-treatment lottery for
Crixivan. J Int Assoc Physicians AIDS Care.
Table 1 Common Antiretroviral Drugs (14-16) Classification Generic Name Trade Name Nucleoside reverse Abacavir sulfate Ziagen transcriptase inhibitors Abacavir sulfate + Trizivir (NRTI) lamivudine + zidovudine Didanosine (ddl) Videx, Videx EC Lamivudine (3TC) Epivir Lamiudine + zidovudine Combivir Stavudine (d4T) Zerit Tenofovir disoproxil Viread fumarate Zalcitabine (ddC) Hivid Zidovudine (AZT, ZDV) Retrovir Non-nucleoside reverse Delavirdine mesylate Rescriptor transcriptase inhibitors Efavirenz Sustiva (NNRTI) Nevirapine Viramune Protease inhibitors (PI) Amprenavir Agenerase Indinavir sulfate
Crixivan Lopinavir + ritonavir Kaletra Nelfinavir Viracept Ritonavir Norvir Saquinavir Fortovase Saquinavir mesylate Invirase Fusion inhibitors (FI) Enfuvirtide Fuzeon
American scientist Joseph Vacca and his team developed
Crixivan, a drug which inhibits the activity of protease, an enzyme in the body used by the HIV virus to reproduce.
Vacca and his team at Merck Research Laboratories, West Point, Pennsylvania, USA, won a non-European countries award for inventing
Crixivan, the protease inhibitor which has "revolutionised HIV treatment worldwide", said the Commission.
Anti-HIV drugs such as
Crixivan were approved in as little as six weeks, and cast as a triumph of AIDS activism.
Crixivan, a protease inhibitor, bloated his rib cage.
Alka-Seltzer, Maalox, Tums, and Rolaids can interfere with the stomach's absorption of Agenerase,
Crixivan, Rescriptor, and Reyataz, while Axid, Pepcid, Tagamet, and Zantac should be entirely avoided by those taking
Crixivan, Rescriptor, and Reyataz.
Merck: The maker of
CRIXIVAN (the HIV protease inhibitor) and ZOCOR (for cholesterol) recently made a 10-year, $20-million grant to the United Negro College Fund and has just entered into a partnership with the People's Republic of China to fight HIV/AIDS.
Novartis further differentiated the products through distinctive packaging; Merck differentiated its HIV/AIDS antiretroviral medicine
CRIXIVAN through special packaging and labeling, i.e., gold-ink printing on the capsule, dark green bottle cap and a bottle label with a light-green background; Pfizer used different coloring and shaping for Diflucan pills supplied to South Africa.
Similar results were reported from a longer-term study in which 62 patients who had been on indinavir (
Crixivan)/efavirenz (Sustiva) regimens for at least 18 months were randomly switched to either efavirenz and two nucleosides or to ritonavir-boosted lopinavir and efavirenz.
In response, Merck, which also manufactures Zocor, Propecia and
Crixivan, has claimed that these news reports have taken documents out of context.
A bottle of pills of the AIDS drug
Crixivan came inside a sealed aluminum can that was itself enclosed in a box labeled "Gold Dye and Stain Remover Wax."
In 1996, Merck launched
Crixivan, a protease inhibitor at a common EU price.
