To examine T gondii strain differences, we analyzed three avirulent (ME49, NTE, and 76K) and two virulent strains (BK and RH) and could observe comparable results within the groups.
Typhimurium) to survive and replicate in host cells, including macrophages, is essential for virulence because mutants that fail to replicate in cultured cell lines are avirulent in vivo (4,5).
The aim of the present study was to examine the protection and antibody response of rainbow trout following intraperitoneal (i.p.) injection of either a live virulent (NCIMB 1113) or an avirulent (NCIMB 1111) isolate of Rs and subsequently, also after a following challenge with the virulent strain.
The dense population structure in biofilms increases the opportunity of gene transfer between the species which can convert a previously avirulent pathogen to a highly virulent pathogen (see Figure 3).
Four pathotypes of NDV have been described by Spradbrow (1987), which are avirulent (causing no disease), lentogenic (low virulence), mesogenic (moderate virulence) and velogenic (high virulence).
In accordance with previous studies, nonencapsulated NL119 was avirulent. However, NL119 P4, which recovered its capsule in vivo, also recovered virulence.