(28) TNF-[alpha], in turn, is a potent inducer of GM-CSF, the other
cytokine that shared variance in Factor 2 of our factor analysis model.
FGF-basic, GM-CSF, IP-10, IFN-[gamma], IL-1[alpha], IL-1[beta], IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, KC, MIP-1-[alpha], MCP-1, MIG, and TNF-[alpha] were evaluated with the mouse
cytokine magnetic 20-Plex panel (Novex[R] by Life Technologies, USA) with the immunoassay Luminex Magpix Platform (Luminex Corporation, USA), as previously described (8).
Nuevolution AB (STO: NUE), a small molecule drug discovery biotech company, on Wednesday announced the identity of its '
Cytokine X' programme being a lead discovery programme targeting inhibition of Interleukin IL-17A using small molecules.
After DNA extraction from the peripheral blood leukocytes using the "salting out" technique (22), the polymerase chain reaction, with sequence-specific primers (PCR-SSP assay kit; Heidelberg University, Germany) was employed for
cytokine gene typing (21).
B-cells can (a) act as antigen-presenting cells, thus activating T-cell responses; (b) act as effector cells producing antibodies (Ab), or (c) have an immunomodulatory role through
cytokine production, which could activate or modulate T-cells or other immune cells (4,5).
The first is via prostaglandins which increase vascular permeability and cause the follicle to rupture, and the second is through nitrogen oxide (NO) leading directly to follicular rupture.4 TNF-a is a
cytokine produced by monocytes and macrophages.
On the day one of ICU stay, without any delay, he was started on extracorporeal
cytokine hemoperfusion therapy for 12 h.
The maintenance of the differentiated TH17 cells is carried out by
cytokine IL-23.
The
cytokine profile of Th17 cells includes IL-17A, IL-17F, IL-21, and IL-22.
Pre-exposure and post-exposure ABR thresholds and
cytokine levels were compared within the groups using the Wilcoxon test, and among groups using the Mann-Whitney U test.
Leukotrienes also can trigger
cytokine synthesis, which can modulate leukotriene receptor function.
