* Group E - coadmin 1 was given
imipramine of 10 mg/kg (i.p.) and ketamine of 10 mg/kg (i.p.).
After acclimatization, mice were dosed with either MAE (100, 300, and 1000 mg [kg.sup.-1], p.o.), fluoxetine (3,10, and 30 mg [kg.sup.-1], p.o.),
imipramine (10, 30, and 100 mg [kg.sup.-1] p.o.), or 1% tween in distilled water (10 ml [kg.sup.-1] p.o.) 60 minutes before behavioural testing.
In addition to the clozapine, she was prescribed
imipramine 200 mg daily.
Imipramine Concentration =
imipramine + desipramine
Similarly, adaptive changes of [5-HT.sub.1A] and [5-HT.sub.2A] receptors were found following chronic administration of
imipramine [54].
In addition, fluoxetine proved better tolerated than
imipramine (odds ratio, 0.23; CrI, 0.04 to 0.78) and duloxetine (OR, 0.31; 95% CrI 0.13 to 0.95).
Antidepressant drugs are classified as: i) selective recapture inhibitors of 5-HT (SSRIs: Fluoxetine, citalopram, etc.) or of NA (NSRIs: Desipramine, reboxetine); ii) of both mono-amines (tricyclic:
Imipramine, nortriptyline); iii) MAO-A inhibitors (tranylcypromine, selegiline, etc.) Notwithstanding, one of the enigmas of pharmacologic treatment is its time gap with therapeutic action (4 to 6 weeks) In this regard, it is propound that antidepressant drugs induce molecular adaptations of greater latency and duration which are more closely related to their therapeutic action.
Iloperidone was continued and
Imipramine was started and patient was asked to follow up after two weeks.
Imipramine monotherapy-induced hyperpigmentation in an adolescent girl.
In the initial trial, Frank et al (23) compared the efficacy of IPT-M with that of pharmacotherapy (
imipramine) in preventing depressive relapse among patients with recurrent depression who had responded to [greater than or equal to]6 sessions of acute IPT and
imipramine and remained well during a 17-week continuation phase.
MacLean (12) noticed that
imipramine, a tricyclic antidepressant, improved patients' enuresis.
The first evidence-based study on this subject was published in 2004 showing that saffron was as efficacious as
imipramine in the short-term treatment of mild to moderate depression in adults (5).
Tricyclics are similar to kynidin in that
imipramine is one of the indicater drugs [2].
Other SSRIs (fluvoxamine, escitalopram), the tricyclic antidepressant
imipramine, and the SNRI duloxetine also had total SD rates significantly greater than placebo.
