- Was the only cast member of Charmed (1998) to want the show to continue.
- Although not credited she was in a back room poker game scene with Rusty (played by Brad Pitt) in "Ocean's Eleven" where she was addressed by her real name.
- Upon Shannen Doherty's departure from Charmed (1998), Holly Marie Combs' character Piper became the oldest sister, despite being the youngest of all four actresses who have played Halliwell sisters in the series.
- The scar in her eyebrow was caused by her walking into a marble table when she was learning to walk.
- Her mother had her when she was only 15.
- Is good friends with Charisma Carpenter.
- Was a bridesmaid at the wedding of Alyssa Milano. (1999)
- Married Charmed (1998) key grip David W. Donoho on February 14, 2004.
- Is only 15 years older than Lucy Hale who plays her daughter on Pretty Little Liars (2010).
- Her acting mentor was: Tom Skerritt.
- Pets: 3 horses (Jake, Jezebel, and Jesse), 4 fish (all nameless), 4 birds (only two of which are named, Lollie and Flower), 6 dogs (Travis, Hugo, Sugar, Thunder, Lola, and Fly Guy), 2 Cats (Blue and Selena), and 2 rabbits (Thumper and Jack). The cats and rabbits are the only pets that live indoors.
- She (along with actresses Tangi Miller and Alyson Hannigan) is a spokesperson for breast cancer, and will appear in a new four page brochure (to be featured in Vogue, Glamour, Self, Mademoiselle, and Women's Sports and Fitness) to raise awareness about the disease. (May 2000)
- In 2016, she met restauranteur Mike Ryan at his Los Angeles restaurant Xoc. On September 3, 2017, Combs announced their engagement on her official Instagram account, sharing a picture of an oval-cut diamond ring. On September 7, 2019, they were married in Carmel, California.
- Best known by the public for her roles as Kimberly Brock on Picket Fences (1992) and as Piper Halliwell on Charmed (1998).
- Mother, with ex-husband David W. Donoho, of sons Finley Arthur Donoho (b. April 26, 2004 via C-section), Riley Edward Donoho (b. October 26, 2006 via C-section) and Kelley James Donoho (b. May 26, 2009 5 weeks premature via emergency C-section).
- Her favorite books include, "The Garden of Eden" by Ernest Hemingway and "Practical Magic" by Alice Hoffman.
- #62 in FHM's 100 sexiest women countdown. (2002)
- Daughter of David Combs and Lauralei Combs.
- #78 in Stuff magazines 103 sexiest women countdown. (2003)
- She is a huge Remy Zero fan.
- Education: Professional Children's School N.Y. Coached by the great Ernie Martin.
- Has been cast in See Me Through (2010) as Dr. Cody Black. (February 2010)
- Stepdaughter of Ed Betinelli, the drummer for the band Preview which was signed to Geffen Records in the 1980s and RCA Records in the 1970s. They opened for Bon Jovi, Pat Benatar, Asia, the Average White Band, The Tubes and Split Enz.
- Was engaged to Storm Lyndon but they split up late in 2000.
- Filmed an unaired pilot called Rockenwagner.
- Has just been cast in Sees Me Through as Dr. Cody Black. (February 2010)
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