Dipropylcyclopentylxanthine
Systematic (IUPAC) name | |
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8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione
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Clinical data | |
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Identifiers | |
CAS Number | 102146-07-6 |
ATC code | none |
PubChem | CID: 1329 |
IUPHAR/BPS | 386 |
ChemSpider | 1289 |
ChEBI | CHEBI:73282 |
ChEMBL | CHEMBL183 |
Chemical data | |
Formula | C16H24N4O2 |
Molecular mass | 304.386 g/mol |
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Physical data | |
Melting point | 191 to 194 °C (376 to 381 °F) |
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8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948) is a drug which acts as a potent and selective antagonist for the adenosine A1 receptor.[1][2] It has high selectivity for A1 over other adenosine receptor subtypes, but as with other xanthine derivatives DPCPX also acts as a phosphodiesterase inhibitor, and is almost as potent as rolipram at inhibiting PDE4.[3] It has been used to study the function of the adenosine A1 receptor in animals,[4][5] which has been found to be involved in several important functions such as regulation of breathing[6] and activity in various regions of the brain,[7][8] and DPCPX has also been shown to produce behavioural effects such as increasing the hallucinogen-appropriate responding produced by the 5-HT2A agonist DOI,[9] and the dopamine release induced by MDMA,[10] as well as having interactions with a range of anticonvulsant drugs.[11][12]
See also
References
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- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Chemical pages without DrugBank identifier
- Articles without KEGG source
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- Drugs not assigned an ATC code
- Adenosine receptor antagonists
- Phosphodiesterase inhibitors
- Xanthines
- Nervous system drug stubs