Arieh Warshel

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Arieh Warshel
AW TW PS.jpg
Warshel near Geneva, Switzerland, May 2009
Born (1940-11-20) November 20, 1940 (age 84)
Kibbutz Sde Nahum, Mandatory Palestine[1]
Nationality Israeli, USA[1]
Fields Chemistry, Biochemistry, Biophysics
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Known for Computer simulation, Computational enzymology, electrostatics, enzyme catalysis
Notable awards Nobel Prize in Chemistry (2013)[1]
Website
laetro.usc.edu
Warshel at press conference at the Royal Swedish Academy of Sciences in Stockholm, December 2013

Arieh Warshel (Hebrew: אריה ורשל‎; born November 20, 1940) is an Israeli-American biochemist and biophysicist. He is a pioneer in computational studies on functional properties of biological molecules. Distinguished Professor of Chemistry and Biochemistry and holds the Dana and David Dornsife Chair in Chemistry at the University of Southern California. He received the 2013 Nobel Prize in Chemistry, together with Michael Levitt and Martin Karplus for "the development of multiscale models for complex chemical systems".[1][2][3][4][5][6]

Biography

Born in 1940 in kibbutz Sde Nahum, Mandatory Palestine. Served in the Israeli Armored Corps. After serving the Israeli Army (final rank Captain), Warshel attended the Technion, Haifa, where he received his BSc degree in Chemistry, Summa Cum Laude, in 1966. Subsequently, he earned both MSc and PhD degrees in Chemical Physics (in 1967 and 1969, respectively), with Shneior Lifson, Weizmann Institute of Science, Israel. After his PhD, he did postdoctoral work at Harvard University until 1972, and from 1972 to 1976 he returned to the Weizmann Institute and worked for the Laboratory of Molecular Biology, Cambridge, England. In 1976 he joined the faculty of the Department of Chemistry at USC. He was awarded the 2013 Nobel Prize in Chemistry.

As a soldier, he fought in both the 1967 Six-Day War and the 1973 Yom Kippur War, attaining the rank of captain in the IDF.[7]

Honors

Warshel is known for his work on computational biochemistry and biophysics, in particular for pioneering computer simulations of the functions of biological systems, and for developing what is known today as Computational Enzymology.[8] He is a member of many scientific organisations, most importantly:

Awards

  • Annual Award of the International Society of Quantum Biology and Pharmacology (1993)[15]
  • Tolman Medal (2003)[16]
  • President’s award for computational biology from the ISQBP (2006)[17]
  • RSC Soft Matter and Biophysical Chemistry Award (2012)[8]
  • Nobel Prize in Chemistry (2013) together with Martin Karplus and Michael Levitt for "the development of multiscale models for complex chemical systems".[18]
  • The Founders Award of the Biophysical Society (2014)[19]
  • The 2013 Israel Chemical Society Gold Medal (2014)[20]

Major research achievements

Arieh Warshel made major contributions in introducing computational methods for structure function correlation of biological molecules, pioneering and co-pioneering programs, methods and key concepts for detailed computational studies of functional properties of biological molecules using Cartesian-based force field programs,[21][22] the combined Quantum Chemistry/Molecular mechanics (i.e., QM/MM) method for simulating enzymatic reactions,[23] the first molecular dynamics simulation of a biological process,[24][25] microscopic electrostatic models for proteins,[26] free energy perturbation in proteins[27] and other key advances. It was for the development of these methods that Warshel shared the 2013 Nobel Prize in Chemistry.

References

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External links

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Awards
Preceded by Nobel Prize in Chemistry laureate
2013
With: Martin Karplus
Michael Levitt		 Most recent
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  7. ↑ 3 Jewish professors — two of them Israeli — share 2013 Nobel Prize in chemistry By Gavriel Fiske, October 9, 2013, Times of Israel
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  17. ↑ http://isqbp.umaryland.edu/ISQBP/newsletters/ISQBP_aug06.pdf
  18. ↑ http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2013/press.pdf
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