Auxilin

DnaJ (Hsp40) homolog, subfamily C, member 6
PDB rendering based on 1n4c.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1n4c, 1nz6, 1xi5
Identifiers
Symbols	DNAJC6 ; DJC6; PARK19
External IDs	OMIM: 608375 MGI: 1919935 HomoloGene: 8865 GeneCards: DNAJC6 Gene
EC number	3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • SH3 domain binding Cellular component • cytosol • neuronal postsynaptic density Biological process • post-Golgi vesicle-mediated transport • peptidyl-tyrosine dephosphorylation • membrane organization • clathrin coat disassembly • regulation of clathrin-mediated endocytosis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9829	72685
Ensembl	ENSG00000116675	ENSMUSG00000028528
UniProt	O75061	Q80TZ3
RefSeq (mRNA)	NM_001256864	NM_001164583
RefSeq (protein)	NP_001243793	NP_001158055
Location (UCSC)	Chr 1: 65.25 – 65.42 Mb	Chr 4: 101.5 – 101.64 Mb
PubMed search	[1]	[2]

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.

Function

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).

Structure

The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.