Epalrestat

Epalrestat

Names
IUPAC name 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
Identifiers
CAS Number	82159-09-9 Y
ChEBI	CHEBI:31539 N
ChEMBL	ChEMBL56337 N
ChemSpider	1285910 N
Jmol 3D model	Interactive image Interactive image
KEGG	D01688 Y
PubChem	1584822
UNII	424DV0807X N
InChI InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8+ N Key: CHNUOJQWGUIOLD-SMTGYRLFSA-N N InChI=1/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8+ Key: CHNUOJQWGUIOLD-SMTGYRLFBD
SMILES CC(=CC1=CC=CC=C1)C=C2C(=O)N(C(=S)S2)CC(=O)O O=C(O)CN1C(=O)C(\SC1=S)=C/C(=C/c2ccccc2)C
Properties
Chemical formula	C15H13NO3S2
Molar mass	319.401 g/mol
Density	1.43 g/cm3
Melting point	210 °C (410 °F; 483 K)
Boiling point	516.8 °C (962.2 °F; 789.9 K)
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. It is well tolerated, with the most commonly reported adverse effects being gastrointestinal issues such as nausea and vomiting, as well as increases in certain liver enzymes.

Chemically, epalrestat is unusual in that it is a drug that contains a rhodanine group.

Brand names

• Aldonil (Zydus Medica), India
• Aldorin, Bangladesh
• Alrista (marketed and not manufactured by Macleods), India
• Epalrica-M (Ordain Global), India
• Eparel 50 (Microlabs Ltd), India
• Epimeth (Zaiva Lifesciences), India
• Eplistat 150 SR (Schem), India
• Letostat-SR (Amor Pharmaceuticals), India
• Listap-50 (Vivid Biotek), India

External links

• Epalrestat at chemblink.com