FBXO6

F-box protein 6
Identifiers
Symbols	FBXO6 ; FBG2; FBS2; FBX6; Fbx6b
External IDs	OMIM: 605647 MGI: 1354743 HomoloGene: 9274 GeneCards: FBXO6 Gene
Gene ontology Molecular function • glycoprotein binding • protein binding • carbohydrate binding • ubiquitin protein ligase activity Cellular component • cytoplasm • SCF ubiquitin ligase complex Biological process • DNA damage checkpoint • DNA repair • proteolysis • glycoprotein catabolic process • response to unfolded protein • protein ubiquitination • ER-associated ubiquitin-dependent protein catabolic process • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26270	50762
Ensembl	ENSG00000116663	ENSMUSG00000055401
UniProt	Q9NRD1	Q9QZN4
RefSeq (mRNA)	NM_018438	NM_001163704
RefSeq (protein)	NP_060908	NP_001157176
Location (UCSC)	Chr 1: 11.66 – 11.67 Mb	Chr 4: 148.15 – 148.15 Mb
PubMed search	[1]	[2]

F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.