Inotuzumab ozogamicin
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | CD22 |
| Identifiers | |
| CAS Number | 635715-01-4  |
| ATC code | none |
| UNII | P93RUU11P7 |
| KEGG | D08933  |
| Chemical data | |
| Formula | C6518H10002N1738O2036S42 |
| Molecular mass | 150,000 Daltons |
| (what is this?) (verify) |
|
Inotuzumab ozogamicin (CMC-544) is an antibody-drug conjugate for the treatment of cancers.[1] It consists of the humanized monoclonal antibody inotuzumab (for CD22), linked to a cytotoxic agent from the class of calicheamicins (which is reflected by 'ozogamicin' in the drug's name).[2]
This drug is being developed by Pfizer and UCB.
It is undergoing numerous clinical trials,[3] including two phase II trials for Non-Hodgkin lymphoma (NHL).
A phase III trial in patients with follicular b-cell NHL has been terminated due to poor enrollment.[4] A Phase III trial in patients with relapsed or refractory CD22+ aggressive non-Hodgkin lymphoma (NHL) who were not candidates for intensive high-dose chemotherapy was terminated for futility.[5]
See also
References
- ↑ Statement On A Nonproprietary Name Adopted By The Usan Council - Inotuzumab ozogamicin, American Medical Association.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://clinicaltrials.gov/ct2/results?term=Inotuzumab+ozogamicin
- ↑ Study Comparing Inotuzumab Ozogamicin In Combination With Rituximab Versus Defined Investigator's Choice In Follicular Non-Hodgkin's Lymphoma (NHL)
- ↑ http://pfizer.newshq.businesswire.com/press-release/pfizer-discontinues-phase-3-study-inotuzumab-ozogamicin-relapsed-or-refractory-aggress
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