L-741,626

L-741,626

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Systematic (IUPAC) name
3-[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
Identifiers
CAS Number	81226-60-0 Y
ATC code	none
PubChem	CID: 133633
IUPHAR/BPS	177
ChemSpider	117877 N
Chemical data
Formula	C20H21ClN2O
Molecular mass	340.134 g/mol
SMILES OC(CC1)(C2=CC=C(Cl)C=C2)CCN1CC3=CNC4=CC=CC=C43
InChI InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2 N Key:LLBLNMUONVVVPG-UHFFFAOYSA-N N
NY (what is this?)  (verify)

L-741,626 is a drug which acts as a potent and selective antagonist for the dopamine receptor D₂. It has good selectivity over the related D₃ and D₄ subtypes and other receptors. L-741,626 is used for laboratory research into brain function and has proved particularly useful for distinguishing D₂ mediated responses from those produced by the closely related D₃ subtype, and for studying the roles of these subtypes in the action of cocaine and amphetamines in the brain.