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Anemia is the most common disorder of the blood. There are several kinds of anemia, produced by a variety of underlying causes. Anemia can be classified in a variety of ways, based on the morphology of RBCs, underlying etiologic mechanisms, and discernible clinical spectra, to mention a few. The three main classes of anemia include excessive blood loss (acutely such as a hemorrhage or chronically through low-volume loss), excessive blood cell destruction (hemolysis) or deficient red blood cell production (ineffective hematopoiesis). Based on 2005-2006 estimates, the Centers for Disease Control and Prevention has stated that approximately 5.5 million Americans a year are either admitted to a hospital or seen by a physician, with some form of anemia as their primary diagnosis.[4]
A nutritional anemia is a type of anemia that can be directly attributed to either a nutritional disorder or a nutritional deficiency.
Condition name |
ICD-10 coding number |
Diseases Database coding number |
Medical Subject Headings |
Iron deficiency anemia |
D50 |
6947 |
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Iron deficiency anemia (or iron deficiency anaemia) is a common anemia that occurs when iron loss (often from intestinal bleeding or menses) occurs, and/or the dietary intake or absorption of iron is insufficient. In such a state, hemoglobin, which contains iron, cannot be formed.[5] |
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Plummer-Vinson syndrome |
D50.1 |
10134 |
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Plummer-Vinson syndrome (PVS), also called Paterson-Brown-Kelly syndrome or sideropenic dysphagia presents as a triad of dysphagia (due to esophageal webs), glossitis, and iron deficiency anemia.[6] It most usually occurs in postmenopausal women. |
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Vitamin B12 deficiency anemia |
E53.8 |
13905 |
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Vitamin B12 deficiency anemia occurs when a "lower-than-normal" amount of the vitamin B12 is available within the body, leading to a decreased production of healthy red blood cells.[7] |
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Vitamin B12 deficiency anemia due to intrinsic factor deficiency |
D51.0 |
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Vitamin B12 deficiency is caused by a lack of intrinsic factor, as seen in pernicious anemia, causes a vitamin B12 deficiency. |
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Pernicious anemia |
D51.0 |
9870 |
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Pernicious anemia (also known as macrocytic achylic anemia, congenital pernicious anemia, juvenile pernicious anemia, and Vitamin B12 deficiency) is one of many types of the larger family of megaloblastic anemias. It is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B12. Pernicious anemia is the result of inadequate production of the protein intrinsic factor needed by the body to absorb vitamin B 12, causing a reduction of new red blood cells.[8] |
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Vitamin B 12 deficiency anemia due to selective vitamin B 12 malabsorption with proteinuria |
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Vitamin B 12 deficiency anemia due to selective vitamin B 12 malabsorption with proteinuria (also known as Imerslund-Gräsbeck syndrome) is a rare autosomal recessive disorder which requires the indefinite administration of Vitamin B12 injections.[9] |
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Megaloblastic hereditary anemia |
D51.1, D52.0, D53.1 |
29507 |
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Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production.[10] |
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Transcobalamin II deficiency |
D51.2 |
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Transcobalamin II deficiency (TCII) (also known as hereditary transcobalamin II deficiency) is a rare autosomal recessive disorder that results in neurological dysfunction.[11] Transcobalamin II are a type of carrier proteins which bind with plasma vitamin B12 (cobalamin) in the production of red blood cells.[12] |
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Folate-deficiency anemia |
D52 E53.8 |
4894 |
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Folate-deficiency anemia (also known as dietary folate-deficiency anemia) is a condition that develops when the body does not have the adequate supply of folic acid available that is needed for the production of new healthy blood cells.[13] |
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Nutritional megaloblastic anemia |
D51.1, D52.0, D53.1 |
29507 |
D000749 |
Nutritional Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production.[10] |
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Drug-induced folate deficiency anemia |
D52.1 |
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Protein deficiency anemia |
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Protein deficiency anemia is an anemia that results from an inadequate intake of dietary protein.[14] |
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Scurvy |
E54 |
13930 |
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Scurvy is a disease resulting from a deficiency of vitamin C,[15] which is required for the synthesis of collagen in humans. |
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Condition name |
ICD-10 coding number |
Diseases Database coding number |
Medical Subject Headings |
Acanthocytosis |
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Acanthocytosis can refer generally to the presence of this type of crenated red blood cell, such as may be found in severe cirrhosis or pancreatitis,[16]:150 but can refer specifically to abetalipoproteinemia, a clinical condition with acanthocytic red blood cells, neurologic problems and steatorrhea.[17]:2464 This particular cause of acanthocytosis (also known as abetalipoproteinemia, apolipoprotein B deficiency, and Bassen-Kornzweig syndrome) is a rare, genetically inherited, autosomal recessive condition due to the inability to fully digest dietary fats in the intestines as a result of various mutations of the microsomal triglyceride transfer protein (MTTP) gene.[18] |
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Acute posthemorrhagic anemia |
D62.0 |
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Acute posthemorrhagic anemia (also known as acute blood loss anemia) is a condition in which a person quickly loses a large volume of circulating hemoglobin. Acute blood loss is usually associated with an incident of trauma or a severe injury resulting in a large loss of blood. It can also occur during or after a surgical procedure.[19] |
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Alpha-thalassemia |
D56.0 |
448
, 33334 , 33678
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Alpha-thalassemia (α-thalassemia) is a form of thalassemia involving the genes HBA1 [20] and HBA2.[21] It is condition that causes a reduction of hemoglobin production. There are two types of Alpha-thalassemia, named hemoglobin Bart hydrops fetalis syndrome (also known as Hb Bart syndrome) and HbH disease.[22] |
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Anemia |
D50-D64 |
663 |
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Anemia is a type of medical condition that results in a decrease in the number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood.[2] |
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Anemia of chronic disease |
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Anemia of chronic disease (ACD) (also known as anemia of inflammatory response) is a condition where the body converts iron into unused ferrin, causing a drop in hemoglobin production, and as a result; decreased red blood cell production and count. This is caused by a natural defense mechanism initiated by an inflammatory response in response to the underlying chronic disease.[23] |
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Anemia in kidney disease and dialysis |
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Anemia in kidney disease and dialysis results from the diseased kidney's inability to produce enough of the hormone erythropoietin. Erythropoietin is used to stimulate an adequate production of red blood cells from the bone marrow.[24] |
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Anemia of prematurity |
P61.2 |
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Anemia of prematurity is a form of anemia affecting preterm infants[25] with decreased hematocrit.[26] |
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Aplastic anemia |
D60-D61 |
866 |
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Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish blood cells.[27] |
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Autoimmune hemolytic anemia |
D59.0-D59.1 |
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Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction (hemolysis).[28][29] Types of AIHA include warm autoimmune hemolytic anemia, cold agglutinin disease, and paroxysmal cold hemoglobinuria. |
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Beta-thalassemia |
D56.1 |
3087 |
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Beta-thalassemia (β-thalassemia) is an autosomal dominant blood condition that results in the reduction of hemoglobin production. The cause for the disorder is related to a genetic mutation of the HBB gene. This gene is responsible for providing the instructions to produce beta-globin; one of the major components of hemoglobin. The two classification types of beta thalassemia are thalassemia major (also known as Cooley's anemia) and thalassemia intermedia.[30] |
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Diamond-Blackfan anemia |
D61.0 |
29062 |
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Diamond–Blackfan anemia (DBA), (also known as Blackfan–Diamond anemia and Inherited erythroblastopenia) [31] is a congenital erythroid aplasia that usually presents in infancy.[32] |
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Congenital dyserythropoietic anemia |
D64.4 |
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Congenital dyserythropoietic anemia (CDA) is a generically inherited autosomal recessive (types I and II) or autosomal dominant (type III) blood disorder that affects the normal maturation process of red blood cell production. Mutations to the CDAN1 gene (type I), SEC23B gene (type II), and a currently unknown gene for type III causes a disruption in the normal formation of erythropoiesis, thereby causing a reduction of circulating healthy mature red blood cells.[33] |
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Drug-induced autoimmune hemolytic anemia |
D59.0 |
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Drug-induced autoimmune hemolytic anemia is a type of hemolytic anemia in which a mediated immune response triggers IgG and IgM antibody production in regards to the presence of high doses of penicillin via the hapten mechanism causing the reduction of red blood cells in the spleen.[34] |
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Drug-induced nonautoimmune hemolytic anemia |
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Glucose-6-phosphate dehydrogenase deficiency |
D55.0 |
19674 |
D005955 |
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Hemoglobinopathy |
D58.2 |
5037 |
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Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule.[35] Hemoglobinopathies are inherited single-gene disorders; in most cases, they are inherited as autosomal co-dominant traits.[36] Hemoglobinopathies imply structural abnormalities in the globin proteins themselves.[37] Hemoglobinopathy variants include sickle-cell disease.[38] |
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Hemolytic anemia |
D55-D59 |
5534 |
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Hemolytic anemia (also known as haemolytic anaemia) is an anemia due to hemolysis, the abnormal breakdown of red blood cells. A number of different mediating factors can cause this condition; either from within the blood cell itself (intrinsic factors) or outside of the cell (extrinsic factors).[39] |
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Congenital hemolytic anemia |
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Fanconi anemia |
D61.0 |
4745 |
D005199 |
Fanconi anemia is a rare genetic autosomal recessive aplastic anemia that involves chromosomes 9q and 20q.[40] |
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Hereditary spherocytosis |
D58.0 |
5827 |
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Hereditary spherocytosis is a genetically-transmitted (autosomal dominant) form of spherocytosis, an auto-hemolytic anemia characterized by the production of red blood cells that are sphere-shaped rather than bi-concave disk shaped (donut-shaped), and therefore more prone to hemolysis.[41] |
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Hereditary elliptocytosis |
D58.1 |
4172 |
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Hereditary elliptocytosis (HE) (also known as ovalocytosis), is an inherited blood disorder in which an abnormally large number of circulating red blood cells are elliptical or cigar shaped rather than the typical biconcave disc shape. It is caused in part by mutations in the formation of specific spectrin tetramers or proteins responsible for giving the red blood cell its shape and elasticity causing continued deformation as the cell matures.[42] Subtypes of this condition include southeast Asian ovalocytosis and spherocytic elliptocytosis. |
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Hereditary pyropoikilocytosis |
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Hereditary pyropoikilocytosis (HPP) is an autosomal recessive form of hemolytic anemia which typically presents at infancy or early childhood, characterized by abnormal red blood cell morphology including "budding red cells, fragmented red cells, spherocytes, elliptocytes, triangular cells, and other bizarre-shaped red cells." [43] |
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Acquired hemolytic anemia |
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Cold hemagglutinin disease |
D59.1 |
2949 |
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Cold hemagglutinin disease (also known as cold agglutinin disease and autoimmune anemia due to cold-reactive antibodies)is an autoimmune disease characterized by the presence of high concentrations of circulating antibodies, usually IgM, directed against red blood cells.[44] It is a form of autoimmune hemolytic anemia, specifically one in which antibodies only bind red blood cells at low body temperatures, typically 28-31 °C. |
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Paroxysmal cold hemoglobinuria |
D59.6 |
9679 |
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Paroxysmal cold hemoglobinuria (PCH) (also known as Donath-Landsteiner syndrome) is a rare condition characterized by the sudden presence of hemoglobin in the urine (called hemoglobinuria), typically after exposure to cold temperatures.[45] |
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Hemolytic-uremic syndrome |
D59.3 |
13052 |
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Hemolytic-uremic syndrome (HUS) (also known as haemolytic-uraemic syndrome) is a disease characterized by hemolytic anemia, acute renal failure (uremia) and a low platelet count (thrombocytopenia). It predominantly but not exclusively affects children. Most cases are preceded by an episode of diarrhea caused by E. coli O157:H7, which is acquired as a foodborne illness.[46] |
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Hereditary persistence of fetal hemoglobin |
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Hereditary stomatocytosis |
D58.8 |
29710 |
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Hereditary stomatocytosis is a classification of inherited autosomal dominant human conditions which affect the red blood cell, in which the membrane or outer coating of the cell 'leaks' sodium and potassium ions, causing cell lyses and eventual haemolytic anaemia. |
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Hexokinase deficiency |
D55.2 |
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Hexokinase deficiency (also known as human erythrocyte hexokinase deficiency) is an anemia-causing condition associated with inadequate hexokinase.[47] |
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Hyperanaemia |
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Hypochromic anemia |
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Hypochromic anemia is any type of anemia in which the red blood cells (erythrocytes) are paler than normal.[48] This is caused by a proportionally reduced amount of hemoglobin present in relation to the size of the red blood cell. |
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Ineffective erythropoiesis |
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Ineffective erythropoiesis is an anemia caused by the premature apoptosis of the body's mature red blood cells [49] and subsequent reduction in an adequate production and full maturation of new healthy red blood cells.[50] |
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Macrocytic anemia |
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Megaloblastic anemia |
D51.1, D52.0, D53.1 |
29507 |
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Megaloblastic anemia (or megaloblastic anaemia) is an anemia of macrocytic classification that results from inhibition of DNA synthesis in red blood cell production.[10] |
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Microangiopathic hemolytic anemia |
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Minkowski-Chauffard syndrome |
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Myelophthisic anemia |
D61.9 |
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Myelophthisic anemia (also known as myelophthisis) is a severe kind of anemia found in some people with diseases that affect the bone marrow. Myelophthisis is the displacement of hemopoietic bone-marrow tissue into the peripheral blood,[51] either by fibrosis, tumors or granulomas. |
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Neuroacanthocytosis |
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29707 |
D054546 |
Neuroacanthocytosis (also known as Levine-Critchley syndrome) is a group of rare, genetic conditions that are characterized by movement disorders and acanthocytosis.[52] |
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Chorea acanthocytosis |
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29707 |
D054546 |
Chorea-acanthocytosis (ChAc)(also known as Levine-Critchley syndrome, acanthocytosis with neurologic disorder, neuroacanthocytosis, and choreoacanthocytosis)[53] is a rare hereditary disease caused by a mutation of the gene that directs structural proteins in red blood cells. It belongs to a group of four diseases characterized as neuroacanthocytosis.[54] |
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Non sideropenic hypochromic anaemia |
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Normocytic anemia |
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A normocytic anemia is an anemia with a mean corpuscular volume (MCV) of 80-100. |
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Paroxysmal nocturnal hemoglobinuria |
D59.5 |
9688 |
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Paroxysmal nocturnal hemoglobinuria (also known as Marchiafava-Micheli syndrome) is a rare, acquired, life-threatening blood disease, with anemia due to red blood cell destruction, red urine, and thrombosis. |
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Pyruvate kinase deficiency |
D55.2 |
11090 |
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Pyruvate kinase deficiency, also called erythrocyte pyruvate kinase deficiency,[55] is an inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of red blood cells and causes them to deform into echinocytes on peripheral blood smears. |
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Rh deficiency syndrome |
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Rh deficiency syndrome is a type of hemolytic anemia that involves erythrocytes whom membranes are deficient in Rh antigens. It is considered a rare condition.[56] |
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Sickle-cell disease |
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Sideroblastic anemia |
D64.0-D64.3 |
12110 |
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Sideroblastic anemia or sideroachrestic anemia is a disease in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes).[57] It may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome.[58] |
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Southeast Asian ovalocytosis |
D58.1 |
9416 |
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Southeast Asian ovalocytosis (also known as stomatocytic ovalocytosis, stomatocytic elliptocytosis, and Melanesian ovalocytosis) is a form of hereditary elliptocytosis common in some communities in Malaysia and Papua New Guinea, as it confers some resistance to cerebral falciparum malaria.[59] |
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Spur cell hemolytic anemia |
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Spur cell hemolytic anemia is a form of hemolytic anemia that results when free cholesterol binds to the red blood cell's membrane increasing its surface area, causing later deformities such as rough or thorny projections on the erythrocyte named acanthocytes. This condition is caused by the deceased liver's decreased ability to esterificate cholesterol.[60] |
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Thalassemia |
D56 |
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D013789 |
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Triosephosphate isomerase deficiency |
D55.2 |
30116 |
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Triosephosphate isomerase (TPI) deficiency is a genetically inherited autosomal recessive condition "characterized bychronic hemolytic anemia, cardiomyopathy, susceptibility to infections, severe neurological dysfunction, and, in most cases, death in early childhood." [61] |
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Warm autoimmune hemolytic anemia |
D59.1 |
29723 |
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Warm autoimmune hemolytic anemia is an autoimmune hemolytic anemia (AIHA) characterized by formation of antibodies that attack the body's own red blood cells in a destructive immune system response.[62] |
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A blood cancer or hematological malignancy is a type of malignant cancer that originates, affects, or involves the blood, bone marrow, or lymph nodes.[63] These cancers include leukemias, lymphomas, and myelomas. These particular types of cancers can arise as defected mature cell types that have differentiated from hematopoietic precursor cells (often in the bone marrow) and begin to quickly proliferate through the bloodstream where it can then often infiltrate other organs and tissues. Others can involve the formation of tumors from lymphoblasts from within the lymphoid tissue.[64] Incidence of affected people with a form of blood cancer has been steady increasing over recent years; however, due in part to early detection methods and subsequent advancements in the treatment of the diseases, mortality rates have continued to decrease.[65]
Condition name |
ICD-10 coding number |
Diseases Database coding number |
Medical Subject Headings |
Hodgkin lymphoma |
C81 |
5973 |
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Non-Hodgkin lymphoma |
C82-C85 |
9065 |
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The non-Hodgkin lymphomas (NHLs) are a diverse group of blood cancers that include any kind of lymphoma except Hodgkin's lymphomas.[66] |
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Anaplastic large cell lymphoma |
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Angioimmunoblastic T-cell lymphoma |
C84.4 |
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Angioimmunoblastic T-cell lymphoma (AILT) (also known as Angioimmunoblastic lymphadenopathy with dysproteinemia)[67]:747 is a mature T-cell lymphoma with systemic characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement.[68] It is also known as immunoblastic lymphadenopathy (Lukes-Collins Classification) and AILD-type (lymphogranulomatosis X) T-cell lymphoma (Kiel Classification).[68] |
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Hepatosplenic T-cell lymphoma |
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Hepatosplenic T-cell lymphoma is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow.[69] It is a rare and generally incurable form of lymphoma.[70] |
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B-cell lymphoma |
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reticuloendotheliosis |
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reticulosis |
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Microglioma |
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Diffuse large B-cell lymphoma |
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Follicular lymphoma |
C82 |
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Follicular lymphoma (also known as indolent follicular lymphoma) is a type of non-Hodgkin's lymphoma that involves both large and small B-cell lymphocytes that spreads from the lymphatic system and into the blood, bone marrow, and internal organs. Approximately 20 to 30 percent of non-Hodgkin's lymphomas are diagnosed as follicular lymphoma, with a majority of cases involving those 60 years of age or older.[71] |
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Mucosa-associated lymphatic tissue lymphoma |
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31339 |
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Mucosa-associated lymphatic tissue lymphoma (as known as MALT lymphoma and extra-nodal marginal zone lymphoma) is a condition in which lymphatic tissue abnormally presents outside the lymphatic system (extra-nodular) and instead within the mucosa of the gastrointestinal tract, typically as a lesion in the stomach.[72] |
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B-cell chronic lymphocytic leukemia |
C91.1 |
2641 |
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B-cell chronic lymphocytic leukemia (also known as small cell lymphocytic lymphoma) is a blood cancer that involves the B-cell lymphocytes; responsible for the creation of antibodies. Of the two general types of chronic lymphocytic leukemias (the other involving T-cells), B-cell chronic lymphocytic leukemia accounts for approximately 95 percent of the diagnoses.[73] |
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Mantle cell lymphoma |
C85.7 |
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Mantle cell lymphoma (MCL) is a type of B-cell lymphoma and one of the rarest forms of non-Hodgkin's lymphomas comprising approximately 6% of diagnosed cases.[74] |
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Burkitt lymphoma |
C83.7 |
1784 |
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Burkitt lymphoma (also known as Burkitt's tumor or malignant lymphoma, Burkitt's type) is a type of B-cell lymphoma that is categorized into one of variant types. These variants are endemic (occurring in equatorial Africa), sporadic ("non-African"), and immunodeficiency-associated (usually associated with HIV). |
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Mediastinal large B cell lymphoma |
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Waldenström's macroglobulinemia |
C88.0 |
14030 |
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Waldenström's macroglobulinemia (also known as lymphoplasmacytic lymphoma) is a lymphoproliferative disease that involves an abnormal increase of lymphocytes within the bone marrow, creasing disruption of normal red blood cell production.[75] |
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Nodal marginal zone B cell lymphoma |
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Splenic marginal zone lymphoma |
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Splenic marginal zone lymphoma (SMZL) (also known as well-differentiated lymphocytic lymphoma, small lymphocytic lymphoma, and splenic lymphoma with circulating villous lymphocytes) is a lymphoma made up of small B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed blasts, and they invade the mantle zone of splenic follicles and erode the marginal zone, ultimately invading the red pulp of the spleen. Frequently, the bone marrow and splenic hilar lymph nodes are involved along with the peripheral blood.[76] |
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Intravascular large B-cell lymphoma |
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Primary effusion lymphoma |
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33904 |
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Primary effusion lymphoma is a condition caused by Kaposi's sarcoma-associated herpesvirus (KSHV).[77] |
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Lymphomatoid granulomatosis |
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Nodular lymphocyte predominant Hodgkin's lymphoma |
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Hematological disorders may be caused by a number of infection-related conditions involving the introduction of microorganisms into the host, such as bacteria and protozoa.[40]