Oltipraz

Oltipraz

Systematic (IUPAC) name
4-methyl-5-(2-pyrazinyl)-3-dithiolethione
Identifiers
CAS Number	64224-21-1 Y
ATC code	none
PubChem	CID: 47318
ChemSpider	43066 N
UNII	6N510JUL1Y Y
ChEBI	CHEBI:77319 N
ChEMBL	CHEMBL178459 N
Chemical data
Formula	C8H6N2S3
Molecular mass	226.34 g/mol
SMILES CC1=C(SSC1=S)C2=NC=CN=C2
InChI InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3 N Key:CKNAQFVBEHDJQV-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical, which can be toxic.