Polidocanol

Polidocanol

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Systematic (IUPAC) name
3,6,9,12,15,18,21,24,27-nonaoxanonatriacontan-1-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	Topical: allowed Injection: contraindication in months 1–3 and after week 36
Legal status	OTC (topical), ℞ (injection)
Routes of administration	topical, subcutaneous injection
Identifiers
CAS Number	9002-92-0 Y Template:CAS
ATC code	C05BB02 (WHO)
PubChem	CID: 656641
ChemSpider	570993 Y
UNII	0AWH8BFG9A N
KEGG	D01993 Y
ChEMBL	CHEMBL1201751 N
Synonyms	Polydocanol Laureth 9 Macrogol lauryl ether Lauromacrogol PEG-9 lauryl alcohol POE-9 lauryl alcohol Dodecylpolyethyleneglycolether Hydroxyl polyethoxy dodecane Oxypolyethoxydodecane
Chemical data
Formula	C30H62O10
Molecular mass	582.8073 g/mol (predicted)
SMILES CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3 Key:ONJQDTZCDSESIW-UHFFFAOYSA-N
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Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by eczema and dry skin. It is formed by the ethoxylation of dodecanol.

The substance is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera, Aethoxysklerol and Varithena. Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.

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Pure polidocanol for pharmaceutical use