SAR1B

Secretion associated, Ras related GTPase 1B
PDB rendering based on 1f6b.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1f6b, 2fa9, 2fmx
Identifiers
Symbols	SAR1B ; ANDD; CMRD; GTBPB; SARA2
External IDs	OMIM: 607690 MGI: 1913647 HomoloGene: 90905 GeneCards: SAR1B Gene
Gene ontology Molecular function • GTPase activity • GTP binding • metal ion binding Cellular component • endoplasmic reticulum membrane • cytosol • ER to Golgi transport vesicle membrane • Golgi cisterna membrane Biological process • antigen processing and presentation of peptide antigen via MHC class I • intracellular protein transport • ER to Golgi vesicle-mediated transport • protein N-linked glycosylation via asparagine • antigen processing and presentation of exogenous peptide antigen via MHC class II • post-translational protein modification • cellular protein metabolic process • small molecule metabolic process • COPII vesicle coating • membrane organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51128	66397
Ensembl	ENSG00000152700	ENSMUSG00000020386
UniProt	Q9Y6B6	Q9CQC9
RefSeq (mRNA)	NM_001033503	NM_025535
RefSeq (protein)	NP_001028675	NP_079811
Location (UCSC)	Chr 5: 134.6 – 134.65 Mb	Chr 11: 51.76 – 51.79 Mb
PubMed search	[1]	[2]

SAR1 gene homolog B (S. cerevisiae), also known as SAR1B, is a protein which in humans is encoded by the SAR1B gene.

Function

SAR1B belongs to the Sar1-ADP ribosylation factor family of small GTPases, which govern the intracellular trafficking of proteins in coat protein (COP)-coated vesicles.

Clinical significance

Mutations in the SAR1B gene are associated with chylomicron retention disease (also known as Anderson disease) which is an autosomal recessive disorder of severe fat malabsorption.